Articles
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Citation: Clinical and Translational Allergy 2011 1(Suppl 1):S14
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Animal models for assessing hypoallergenic clinical performance potential of products based on hydrolyzed protein systems
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):O17 -
Comparison of the immune response induced in mice experimentally sensitized with genetically modified MON810 maize vs its conventional counterpart
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):O21 -
Atopic dermatitis and food allergy: when and how to test?
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):S25 -
Angiotensin converting enzyme-gene polymorphisms in normal subjects, atopic individuals and those with anaphylaxis to venom, food and drugs
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):O45 -
CMA: how long does it last for?
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):S51 -
Peadiatric wheat challenge study-preliminary results
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):P64 -
Applications of novel vaccines to immotherapy of food allergy
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):S79 -
In vivo and in vitro studies on the sensitisation to a panel of allergens in a large rosacea allergic group of patients
Citation: Clinical and Translational Allergy 2011 1(Suppl 1):P99 -
Effects of atopy and rhinitis on exhaled nitric oxide values - a systematic review
Atopy and rhinitis are among the factors affecting exhaled nitric oxide (FeNO) values and may contribute to difficulties in the clinical interpretation of FeNO measurements. However, data assessing their effec...
Citation: Clinical and Translational Allergy 2011 1:8 -
Vitamin C and asthma in children: modification of the effect by age, exposure to dampness and the severity of asthma
We previously found a significant benefit of vitamin C supplementation in asthmatic children.
Citation: Clinical and Translational Allergy 2011 1:9 -
Risk of allergic reactions to wine, in milk, egg and fish-allergic patients
European legislators and wine producers still debate on the requirement for labeling of wines fined with potentially allergenic food proteins (casein, egg white or fish-derived isinglass). We investigated whet...
Citation: Clinical and Translational Allergy 2011 1:10 -
Allergic diseases in the elderly
Demographic distribution of the population is progressively changing with the proportion of elderly persons increasing in most societies. This entails that there is a need to evaluate the impact of common dise...
Citation: Clinical and Translational Allergy 2011 1:11 -
Comparing the effects of two inhaled glucocorticoids on allergen-induced bronchoconstriction and markers of systemic effects, a randomised cross-over double-blind study
Inhaled glucocorticoids are efficient in protecting against asthma exacerbations, but methods to compare their efficacy vs systemic effects have only been attempted in larger multi-centre studies. The aim of t...
Citation: Clinical and Translational Allergy 2011 1:12 -
Peptide immunotherapy for childhood allergy - addressing translational challenges
Allergic sensitisation usually begins early in life. The number of allergens a patient is sensitised to can increase over time and the development of additional allergic conditions is increasingly recognised. ...
Citation: Clinical and Translational Allergy 2011 1:13 -
Exhaled nitric oxide decreases after positive food-allergen challenge
Exhaled nitric oxide (FeNO) is a well described marker of airway inflammation in asthma and is also known to increase after chronic exposure to inhaled allergens. It is not known whether monitoring FeNO could ...
Citation: Clinical and Translational Allergy 2011 1:14 -
Sensitization to cereals and peanut evidenced by skin prick test and specific IgE in food-tolerant, grass pollen allergic patients
The botanical relation between grass and cereal grains may be relevant when diagnosing food allergy to cereals. The aim was to investigate the diagnostic specificity of skin prick test (SPT) and specific immun...
Citation: Clinical and Translational Allergy 2011 1:15 -
Quantification of atopy, lung function and airway hypersensitivity in adults
Studies in children have shown that concentration of specific serum IgE (sIgE) and size of skin tests to inhalant allergens better predict wheezing and reduced lung function than the information on presence or...
Citation: Clinical and Translational Allergy 2011 1:16 -
Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catalyzing enzyme. It has been suggested that it has a role in lower airway allergic inflammations, but its role in allergic rhinitis has not been investigated.
Citation: Clinical and Translational Allergy 2011 1:17 -
Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis
For the development of forecasts for seasonal allergic rhinitis symptoms, it is essential to understand the relationship between grass pollen concentrations and the symptoms of grass pollen allergic patients.
Citation: Clinical and Translational Allergy 2011 1:18 -
Conventional epidemiology underestimates the incidence of asthma and wheeze-a longitudinal population-based study among teenagers
Because of shifts in the gender ratio and incidence and remission rates of asthma during the teen ages, the methodology of incidence studies among teenagers is important, i.e. if the time intervals between sur...
Citation: Clinical and Translational Allergy 2012 2:1 -
Mechanisms of allergen-specific immunotherapy
Allergen-specific immunotherapy (allergen-SIT) is a potentially curative treatment approach in allergic diseases. It has been used for almost 100 years as a desensitizing therapy. The induction of peripheral T...
Citation: Clinical and Translational Allergy 2012 2:2 -
What factors affect the carriage of epinephrine auto-injectors by teenagers?
Teenagers with allergies are at particular risk of severe and fatal reactions, but epinephrine auto-injectors are not always carried as prescribed. We investigated barriers to carriage.
Citation: Clinical and Translational Allergy 2012 2:3 -
Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions
Grass pollen allergens are a major cause of allergic respiratory disease but traditionally prescribing practice for grass pollen allergen-specific immunotherapy has favoured pollen extracts of temperate grasse...
Citation: Clinical and Translational Allergy 2012 2:4 -
FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies
The FAST project (Food Allergy Specific Immunotherapy) aims at the development of safe and effective treatment of food allergies, targeting prevalent, persistent and severe allergy to fish and peach. Classical...
Citation: Clinical and Translational Allergy 2012 2:5 -
Erratum to: Vitamin C and asthma in children: modification of the effect by age, exposure to dampness and the severity of asthma
Citation: Clinical and Translational Allergy 2012 2:6 -
Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways
Allergen induced early phase airway response and airway plasma exudation are predominantly mediated by inflammatory mast cell mediators including histamine, cysteinyl leukotrienes (cysLTs) and thromboxane A2 (...
Citation: Clinical and Translational Allergy 2012 2:7 -
Allergen-specific immunotherapy provides immediate, long-term and preventive clinical effects in children and adults: the effects of immunotherapy can be categorised by level of benefit -the centenary of allergen specific subcutaneous immunotherapy
Allergen Specific Immunotherapy (SIT) for respiratory allergic diseases is able to significantly improve symptoms as well as reduce the need for symptomatic medication, but SIT also has the capacity for long-t...
Citation: Clinical and Translational Allergy 2012 2:8 -
Explorative study on patient’s perceived knowledge level, expectations, preferences and fear of side effects for treatment for allergic rhinitis
In spite of the high prevalence of allergic rhinitis (AR) and the evidence-based guidelines for treatment, little is known about the patients’ perceived knowledge level, expectations, preferences for treatment...
Citation: Clinical and Translational Allergy 2012 2:9 -
Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibiotics
In the general population, reports on suspected ß-lactam hypersensitivity are common. After a drug allergy work-up at best 20% of the selected patients are positive. However, these considerations have not been...
Citation: Clinical and Translational Allergy 2012 2:10 -
Combined fluticasone furoate/vilanterol reduces decline in lung function following inhaled allergen 23 h after dosing in adult asthma: a randomised, controlled trial
There is a need for preventative asthma maintenance therapy that provides lasting bronchoprotection against allergen provocation. Fluticasone furoate (FF) is a novel inhaled once-daily corticosteroid, being in...
Citation: Clinical and Translational Allergy 2012 2:11 -
The strategies that peanut and nut-allergic consumers employ to remain safe when travelling abroad
An understanding of the management strategies used by food allergic individuals is needed as a prerequisite to improving avoidance and enhancing quality of life. Travel abroad is a high risk time for severe an...
Citation: Clinical and Translational Allergy 2012 2:12 -
The release of IL-31 and IL-13 after nasal allergen challenge and their relation to nasal symptoms
IL-31, a recently discovered member of the gp130/IL-6 cytokine family, is mainly expressed by human mast cells and T helper type 2 cells. IL-31 is a key trigger of atopic dermatitis. Recent studies also sugges...
Citation: Clinical and Translational Allergy 2012 2:13 -
Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features
Human rhinoviruses, major precipitants of asthma exacerbations, induce lower airway inflammation and mediate angiogenesis. The purpose of this study was to assess the possibility that rhinoviruses may also con...
Citation: Clinical and Translational Allergy 2012 2:14 -
Prevalence of asthma in Portugal - The Portuguese National Asthma Survey
Asthma is a frequent chronic respiratory disease in both children and adults. However, few data on asthma prevalence are available in Portugal. The Portuguese National Asthma Survey is the first nationwide stu...
Citation: Clinical and Translational Allergy 2012 2:15 -
Control of Allergic Rhinitis and Asthma Test (CARAT) can be used to assess individual patients over time
The Control of Allergic Rhinitis and Asthma Test (CARAT10) has been proposed as the first tool to implement the Allergic Rhinitis and its Impact on Asthma initiative guidelines in clinical practice. To serve t...
Citation: Clinical and Translational Allergy 2012 2:16 -
Prospective validation of the “rhino conjunctivitis allergy-control-SCORE©” (RC-ACS©)
Recently we reported the validation of the “Allergy-Control-SCORE© (ACS)” which assesses symptom severity as well as medication use on three dimensions lung, nose and eyes. The aim of this study was to test the v...
Citation: Clinical and Translational Allergy 2012 2:17 -
Dysfunctional breathing phenotype in adults with asthma - incidence and risk factors
Abnormal breathing patterns may cause characteristic symptoms and impair quality of life. In a cross-sectional survey 29% of adults treated for asthma in primary care had symptoms suggestive of dysfunctional b...
Citation: Clinical and Translational Allergy 2012 2:18 -
A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria
The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The ...
Citation: Clinical and Translational Allergy 2012 2:19 -
EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
Allergy today is a public health concern of pandemic proportions, affecting more than 150 million people in Europe alone. In view of epidemiological trends, the European Academy of Allergy and Clinical Immunol...
Citation: Clinical and Translational Allergy 2012 2:20 -
Research needs in allergy: an EAACI position paper, in collaboration with EFA
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to ...
Citation: Clinical and Translational Allergy 2012 2:21 -
Intact skin and not stripped skin is crucial for the safety and efficacy of peanut epicutaneous immunotherapy (EPIT) in mice
Epicutaneous immunotherapy (EPIT) on intact skin with an epicutaneous delivery system has already been used in preclinical and clinical studies. In epicutaneous vaccination and immunotherapy, the stripping of ...
Citation: Clinical and Translational Allergy 2012 2:22 -
The 11S globulin Sin a 2 from yellow mustard seeds shows IgE cross-reactivity with homologous counterparts from tree nuts and peanut
The 11S globulin Sin a 2 is a marker to predict severity of symptoms in mustard allergic patients. The potential implication of Sin a 2 in cross-reactivity with tree nuts and peanut has not been investigated s...
Citation: Clinical and Translational Allergy 2012 2:23 -
Exploring the temporal development of childhood IgE profiles to allergen components
Children often develop allergies that may or not persist into adulthood. Although the different allergic symptoms over time have been well documented, the underlying pattern of sensitization to various protein...
Citation: Clinical and Translational Allergy 2012 2:24 -
Food allergies in developing and emerging economies: need for comprehensive data on prevalence rates
Although much is known today about the prevalence of food allergy in the developed world, there are serious knowledge gaps about the prevalence rates of food allergy in developing countries. Food allergy affec...
Citation: Clinical and Translational Allergy 2012 2:25 -
Physical activity in adults with controlled and uncontrolled asthma as compared to healthy adults: a cross-sectional study
Though exercise-induced bronchoconstriction is common among asthmatics, physical activity (PA) seems important in asthma management. Still, various studies point at avoidance of sports and certain daily life a...
Citation: Clinical and Translational Allergy 2013 3:1 -
Living with severe allergy: an Anaphylaxis Campaign national survey of young people
The transition to adulthood can be particularly challenging for young people with severe allergies, who must learn to balance personal safety with independent living. Information and support for young people a...
Citation: Clinical and Translational Allergy 2013 3:2 -
The skin prick test – European standards
Skin prick testing is an essential test procedure to confirm sensitization in IgE-mediated allergic disease in subjects with rhinoconjunctivitis, asthma, urticaria, anapylaxis, atopic eczema and food and drug ...
Citation: Clinical and Translational Allergy 2013 3:3 -
Management of hypersensivity pneumonitis
Hypersensitivity pneumonitis (HP) is an interstitial lung disease due to a combined type III and IV reaction with a granulomatous inflammation, caused by cytotoxic delayed hypersensitivity lymphocytes, in a Th...
Citation: Clinical and Translational Allergy 2013 3:5 -
Inability to detect significant absorption of immunoreactive soya protein in healthy adults may be relevant to its weak allergenicity
Soya and peanut are botanically closely related and share cross-reacting antigens, but compared to soya, peanut allergy has a higher prevalence with more severe allergic reactions. Furthermore, the threshold d...
Citation: Clinical and Translational Allergy 2013 3:6