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  1. Farmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respirator...

    Authors: T. Sigsgaard, I. Basinas, G. Doekes, F. de Blay, I. Folletti, D. Heederik, A. Lipinska-Ojrzanowska, D. Nowak, M. Olivieri, S. Quirce, M. Raulf, J. Sastre, V. Schlünssen, J. Walusiak-Skorupa and A. Siracusa

    Citation: Clinical and Translational Allergy 2020 10:29

    Content type: Review

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  2. Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid as...

    Authors: Ming Wang, Xiangting Bu, Ge Luan, Liqing Lin, Yang Wang, Jianmin Jin, Luo Zhang and Chengshuo Wang

    Citation: Clinical and Translational Allergy 2020 10:26

    Content type: Research

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  3. House dust mite (HDM) allergens constitute the most frequent cause of persistent allergic rhinitis and asthma. The symptoms vary throughout the year but typically peak in spring, autumn and (to a lesser extent...

    Authors: Pascal Demoly, Andrea Matucci, Oliviero Rossi and Carmen Vidal

    Citation: Clinical and Translational Allergy 2020 10:27

    Content type: Research

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  4. Concerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use...

    Authors: V. Mahler, D. Mentzer, A. Bonertz, A. Muraro, P. Eigenmann, J. Bousquet, S. Halken, O. Pfaar, M. Jutel, U. Wahn, S. Vieths and S. Kaul

    Citation: Clinical and Translational Allergy 2020 10:28

    Content type: Review

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  5. A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis with nasal polyps (CRSwNP), the presence of which may adversely...

    Authors: Enrico Heffler, Fabiana Saccheri, Marta Bartezaghi and Giorgio Walter Canonica

    Citation: Clinical and Translational Allergy 2020 10:25

    Content type: Research

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  6. In December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the F...

    Authors: Jean Bousquet, Josep M. Anto, Tari Haahtela, Pekka Jousilahti, Marina Erhola, Xavier Basagaña, Wienczyslawa Czarlewski, Mikaëla Odemyr, Susanna Palkonen, Mikael Sofiev, César Velasco, Anna Bedbrook, Rodrigo Delgado, Rostislav Kouznetsov, Mika Mäkelä, Yuliia Palamarchuk…

    Citation: Clinical and Translational Allergy 2020 10:24

    Content type: Review

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  7. Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

    Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti

    Citation: Clinical and Translational Allergy 2020 10:23

    Content type: Review

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  8. Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic protei...

    Authors: Claudia Alessandri, Rosetta Ferrara, Maria Livia Bernardi, Danila Zennaro, Lisa Tuppo, Ivana Giangrieco, Teresa Ricciardi, Maurizio Tamburrini, Maria Antonietta Ciardiello and Adriano Mari

    Citation: Clinical and Translational Allergy 2020 10:22

    Content type: Review

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  9. Intramuscular (IM) injection of epinephrine (adrenaline) at the mid-anterolateral (AL) thigh is the international standard therapy for acute anaphylaxis. Concerns exist regarding implications of epinephrine au...

    Authors: Margitta Worm, DucTung Nguyen, Russ Rackley, Antonella Muraro, George Du Toit, Tracey Lawrence, Hong Li, Kurt Brumbaugh and Magnus Wickman

    Citation: Clinical and Translational Allergy 2020 10:21

    Content type: Research

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  10. New recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. These recommendations provide very important changes to the management of asthma, especi...

    Authors: Izabela Kuprys-Lipinska, Marta Kolacinska-Flont and Piotr Kuna

    Citation: Clinical and Translational Allergy 2020 10:19

    Content type: Review

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  11. Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later lif...

    Authors: Giovanni A. Rossi, Petr Pohunek, Wojciech Feleszko, Stefania Ballarini and Andrew A. Colin

    Citation: Clinical and Translational Allergy 2020 10:17

    Content type: Review

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  12. Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. Malassezia globosa, a skin resident fungus...

    Authors: Sabine Altrichter, Pia Schumacher, Ola Alraboni, Yiyu Wang, Makiko Hiragun, Michihiro Hide and Marcus Maurer

    Citation: Clinical and Translational Allergy 2020 10:18

    Content type: Research

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  13. Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most curren...

    Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

    Citation: Clinical and Translational Allergy 2020 10:16

    Content type: Review

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  14. Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited.

    Authors: Erik Melén, Anna Bergström, Inger Kull, Catarina Almqvist, Niklas Andersson, Anna Asarnoj, Magnus P. Borres, Antonis Georgellis, Göran Pershagen, Marit Westman, Marianne van Hage and Natalia Ballardini

    Citation: Clinical and Translational Allergy 2020 10:15

    Content type: Research

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  15. The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources ...

    Authors: Kitty Verhoeckx, Katrine Lindholm Bøgh, Anne Constable, Michelle M. Epstein, Karin Hoffmann Sommergruber, Thomas Holzhauser, Geert Houben, Annette Kuehn, Erwin Roggen, Liam O’Mahony, Ben Remington and René Crevel

    Citation: Clinical and Translational Allergy 2020 10:13

    Content type: Review

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  16. Worldwide, guidelines recommend the use of adrenaline autoinjectors (AAIs) for self-medication in patients who experience severe allergic reaction. The European Medical Agency recommends the prescription of tw...

    Authors: Magdalena Kraft, Sabine Dölle-Bierke, Paul J. Turner, Antonella Muraro, Montserrat Fernández-Rivas, Linus Grabenhenrich and Margitta Worm

    Citation: Clinical and Translational Allergy 2020 10:12

    Content type: Research

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  17. Allergen immunotherapy (AIT) is the only treatment option available for allergic patients with disease-modifying intention. Both efficacy and safety has been demonstrated for multiple trials in children, adole...

    Authors: O. Pfaar, R. Gerth van Wijk, L. Klimek, J. Bousquet and P. S. Creticos

    Citation: Clinical and Translational Allergy 2020 10:11

    Content type: Review

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  18. Pollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previou...

    Authors: Thomas Proctor, Elodie Morrough, Otto Fenske, Sarah Allatt, Stephen M. Hughes, Vibha Sharma and Peter D. Arkwright

    Citation: Clinical and Translational Allergy 2020 10:10

    Content type: Research

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  19. Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.

    Authors: Dimitrios I. Mitsias, Maria V. Dimou, John Lakoumentas, Konstantinos Alevizopoulos, Bernardo Sousa-Pinto, Joao A. Fonseca, Jean Bousquet and Nikolaos G. Papadopoulos

    Citation: Clinical and Translational Allergy 2020 10:9

    Content type: Research

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  20. Hymenoptera venom allergy (HVA) is an underestimated condition representing an important cause of morbidity and mortality worldwide. Preventing future allergic reactions in patients who have already developed ...

    Authors: Maria Beatrice Bilò, Alice Corsi, Valerio Pravettoni, Donatella Bignardi, Patrizia Bonadonna, Oliviero Quercia, Marina Mauro, Elio Novembre, Rebecca Micheletti and Roberto Papa

    Citation: Clinical and Translational Allergy 2020 10:8

    Content type: Research

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  21. Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only r...

    Authors: Viiu Blöndal, Fredrik Sundbom, Magnus P. Borres, Marieann Högman, Kjell Alving, Andrei Malinovschi and Christer Janson

    Citation: Clinical and Translational Allergy 2020 10:6

    Content type: Research

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  22. Eczema phenotypes based on eczema onset and persistence might better identify groups prone to allergic and respiratory conditions than a binary definition of eczema. We examined the associations of childhood e...

    Authors: Chen Hu, Tamar Nijsten, Evelien R. van Meel, Nicole S. Erler, Christophe Piketty, Nicolette W. de Jong, Suzanne G. M. A. Pasmans, Johan C. de Jongste and Liesbeth Duijts

    Citation: Clinical and Translational Allergy 2020 10:7

    Content type: Research

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  23. Carboplatin administration can usually be safely continued via a so-called desensitisation protocol when hypersensitivity reactions arise. Severe break-through reactions that occur early during desensitisation...

    Authors: Hanneke N. G. Oude Elberink, Mathilde Jalving, Hilda Dijkstra and Annick A. J. M. van de Ven

    Citation: Clinical and Translational Allergy 2020 10:5

    Content type: Letter to the Editor

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  24. Clean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase th...

    Authors: Jussi Lampi, Anne Hyvärinen, Marina Erhola, Tari Haahtela, Kyösti Haukipuro, Ulla Haverinen-Shaughnessy, Kaisa Jalkanen, Kirsi Karvala, Sanna Lappalainen, Kari Reijula, Hannele Rämö, Markku Sainio, Anniina Salmela, Mika Salminen, Tuula Vasankari and Juha Pekkanen

    Citation: Clinical and Translational Allergy 2020 10:4

    Content type: Research

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  25. Previous studies have suggested an increased risk of asthma related to indoor dampness problems, but their role in the etiology of Asthma-COPD Overlap Syndrome has not been studied. We utilized a population-ba...

    Authors: Maritta S. Jaakkola, Taina K. Lajunen and Jouni J. K. Jaakkola

    Citation: Clinical and Translational Allergy 2020 10:3

    Content type: Research

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  26. Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in deta...

    Authors: Frank E. van Boven, Nicolette W. de Jong, Gert-Jan Braunstahl, Roy Gerth van Wijk and Lidia R. Arends

    Citation: Clinical and Translational Allergy 2020 10:2

    Content type: Review

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  27. Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been ...

    Authors: Valerie Hox, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol…

    Citation: Clinical and Translational Allergy 2020 10:1

    Content type: Review

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  28. IgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (D...

    Authors: Haziq Emran, Christina Siew Eng Chieng, Surita Taib and Anne Catherine Cunningham

    Citation: Clinical and Translational Allergy 2019 9:65

    Content type: Research letter

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  29. Data regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52 weeks were followed...

    Authors: Yanran Huang, Chengshuo Wang, Xi Lin, Hongfei Lou, Feifei Cao, Wenhan Li, Yuan Zhang and Luo Zhang

    Citation: Clinical and Translational Allergy 2019 9:64

    Content type: Letter to the Editor

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  30. Rhinovirus A and C infections are important contributors to asthma induction and exacerbations. No data exist on the interaction of local immune responses in rhinovirus infection. Therefore, we aimed to determ...

    Authors: Emilia Mikola, Oscar Palomares, Riitta Turunen, Matti Waris, Lotta E. Ivaska, Antti Silvoniemi, Tuomo Puhakka, Beate Rückert, Tytti Vuorinen, Mübeccel Akdis, Cezmi A. Akdis and Tuomas Jartti

    Citation: Clinical and Translational Allergy 2019 9:63

    Content type: Research

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  31. The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress inflammatory responses in different cells. In this study,...

    Authors: Anet Kivihall, Alar Aab, Jerzy Soja, Krzysztof Sładek, Marek Sanak, Alan Altraja, Bogdan Jakiela, Grazyna Bochenek and Ana Rebane

    Citation: Clinical and Translational Allergy 2019 9:62

    Content type: Research

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  32. Our meta-analysis of several ethnic groups (Japanese, Korean, Indian, Brazilian) revealed a significant genome-wide association between cold medicine-related SJS/TEN (CM-SJS/TEN) with severe ocular complicatio...

    Authors: Patchima Chantaren, Passara Jongkhajornpong, Mayumi Ueta, Vilavun Puangsricharern, Kaevalin Lekhanont, Phattrawan Pisuchpen, Pinnita Prabhasawat, Kanya Suphapeetiporn and Shigeru Kinoshita

    Citation: Clinical and Translational Allergy 2019 9:61

    Content type: Research letter

    Published on:

  33. The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI inclu...

    Authors: C. A. Akdis, J. Bousquet, C. E. Grattan, P. A. Eigenmann, K. Hoffmann-Sommergruber, I. Agache and M. Jutel

    Citation: Clinical and Translational Allergy 2019 9:60

    Content type: Review

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  34. This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe ...

    Authors: Louise Parke, Annemarie Schaeffer Senders, Carsten Bindslev-Jensen, Annmarie Touborg Lassen, Athamaica Ruiz Oropeza, Susanne Halken, Sigurd Broesby-Olsen, Henrik Fomsgaard Kjær and Charlotte G. Mortz

    Citation: Clinical and Translational Allergy 2019 9:59

    Content type: Research Letter

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  35. Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the...

    Authors: C. Nitsche, C. D. Westerlaken-van Ginkel, B. J. Kollen, A. B. Sprikkelman, G. H. Koppelman and A. E. J. Dubois

    Citation: Clinical and Translational Allergy 2019 9:58

    Content type: Letter to the Editor

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  36. The Nature Step to Respiratory Health was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed t...

    Authors: Tari Haahtela, Leena von Hertzen, Josep M. Anto, Chunxue Bai, Abay Baigenzhin, Eric D. Bateman, Digambar Behera, Kazi Bennoor, Paulo Camargos, Niels Chavannes, Jaime Correia de Sousa, Alvaro Cruz, Maria Do Céu Teixeira, Marina Erhola, Eeva Furman, Bilun Gemicioğlu…

    Citation: Clinical and Translational Allergy 2019 9:57

    Content type: Review

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  37. Temporal ecological studies have shown that outdoor moulds are associated with severe asthma exacerbations, as emergency department visits or hospitalisations. The aim of this was to assess the associations be...

    Authors: D. M. Caillaud, S. Martin, C. Ségala, N. Dupuy, M. Thibaudon and D. Muti

    Citation: Clinical and Translational Allergy 2019 9:56

    Content type: Letter to the Editor

    Published on:

  38. Hymenoptera stings are a major cause of anaphylaxis. Various risk factors are discussed in literature. This study aims to investigate potential risk factors for severe sting reactions in wasp (Vespula spp.) and h...

    Authors: Danielle Fehr, Sara Micaletto, Thomas Moehr and Peter Schmid-Grendelmeier

    Citation: Clinical and Translational Allergy 2019 9:54

    Content type: Research

    Published on:

  39. Following publication of the original article [1], the authors reported that one of the authors’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author...

    Authors: J. Bousquet and M. van Hage

    Citation: Clinical and Translational Allergy 2019 9:53

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2016 6:47

  40. Following publication of the original article [1], the authors reported that one of the collaborators’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the ...

    Authors: J. Bousquet

    Citation: Clinical and Translational Allergy 2019 9:52

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2019 9:16

  41. Following publication of the original article [1], the authors reported that one of the collaborators’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the ...

    Authors: J. Bousquet

    Citation: Clinical and Translational Allergy 2019 9:51

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2018 8:45

  42. Different clinical trials showed the superior efficacy of rupatadine compared to placebo at improving seasonal allergic rhinitis (SAR) symptoms, but no study has assessed if the response promoted is clinically...

    Authors: Joaquim Mullol, Iñaki Izquierdo, Kimihiro Okubo, Giorgio Walter Canonica, Jean Bousquet and Antonio Valero

    Citation: Clinical and Translational Allergy 2019 9:50

    Content type: Research

    Published on:

  43. Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monoc...

    Authors: Hua Peng, Jian Wang, Xiao Yan Ye, Jie Cheng, Cheng Zhi Huang, Li Yue Li, Tian Ying Li and Chun Wei Li

    Citation: Clinical and Translational Allergy 2019 9:49

    Content type: Letter to the Editor

    Published on:

  44. Chronic urticaria is a disease characterized by the appearance of weals, angioedema or both longer than 6 weeks. Degranulation of cutaneous or submucosal mast cells leads to release of mediators including hist...

    Authors: Emek Kocatürk and Clive Grattan

    Citation: Clinical and Translational Allergy 2019 9:48

    Content type: Review

    Published on:

  45. Recurrent use of oral corticosteroids (OCS) and over-use of short-acting beta-2-agonists (SABA) are factors associated with adverse side effects and asthma-related death. We aim to quantify high OCS exposure, ...

    Authors: Ana Sá-Sousa, Rute Almeida, Ricardo Vicente, Nilton Nascimento, Henrique Martins, Alberto Freitas and João Almeida Fonseca

    Citation: Clinical and Translational Allergy 2019 9:47

    Content type: Research

    Published on:

  46. Recommendations on contraindications to allergen immunotherapy (AIT) have been independently developed by National and International Societies/Academies. AIT contraindications are mainly based on case reports,...

    Authors: C. Pitsios, M. Tsoumani, M. B. Bilò, G. J. Sturm, P. Rodríguez del Río, R. Gawlik, F. Ruëff, G. Paraskevopoulos, E. Valovirta, O. Pfaar, M. A. Calderón and P. Demoly

    Citation: Clinical and Translational Allergy 2019 9:45

    Content type: Review

    Published on:

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