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  1. Analysis of cross-reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam most often involved in immediate hypersensitivity reactions (I...

    Authors: Gador Bogas, Cristobalina Mayorga, Ángela Martín-Serrano, Rubén Fernández-Santamaría, Isabel M. Jiménez-Sánchez, Adriana Ariza, Esther Barrionuevo, Teresa Posadas, María Salas, Tahía Diana Fernández, María José Torres and María Isabel Montañez

    Citation: Clinical and Translational Allergy 2020 10:57

    Content type: Research

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  2. There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating la...

    Authors: Jean Bousquet, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Anto, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, Guido Iaccarino, Hubert Blain, Alessandro Fiocchi, G. Walter Canonica, Joao A. Fonseca, Alain Vidal, Hak-Jong Choi, Hyun Ju Kim, Vincent Le Moing…

    Citation: Clinical and Translational Allergy 2020 10:58

    Content type: Review

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  3. The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

    Authors: J. Bousquet, C. E. Grattan, C. A. Akdis, P. A. Eigenmann, K. Hoffmann-Sommergruber, I. Agache and M. Jutel

    Citation: Clinical and Translational Allergy 2020 10:56

    Content type: Review

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  4. Macadamia nut can induce fatal allergic reactions and changes in dietary habits will raise their consumption in industrialised countries. Until now diagnosis of macadamia nut allergy by sIgE solely relies on t...

    Authors: Anna M. Ehlers, Stefanie Rohwer, Henny G. Otten, Bettina Brix, Thuy-My Le, Waltraud Suer and André C. Knulst

    Citation: Clinical and Translational Allergy 2020 10:55

    Content type: Letter to the Editor

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  5. A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the...

    Authors: Lukas Jörg, Arthur Helbling, Daniel Yerly and Werner J. Pichler

    Citation: Clinical and Translational Allergy 2020 10:52

    Content type: Research

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  6. Anaphylaxis has been increasing in developed countries but there is very little published data on the burden of anaphylaxis and the pattern of adrenaline autoinjector (AAI) prescription from Asia. We aim to de...

    Authors: Philip Hei Li, Agnes S. Y. Leung, Rebecca M. Y. Li, Ting-fan Leung, Chak-sing Lau and Gary W. K. Wong

    Citation: Clinical and Translational Allergy 2020 10:51

    Content type: Research

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  7. Artemisia weed pollen allergy is important in the northern hemisphere. While over 350 species of this genus have been recorded, there has been no full investigation into whether different species may affect the a...

    Authors: Lan Zhao, Wanyi Fu, Biyuan Gao, Yi Liu, Shandong Wu, Zhi Chen, Xianqi Zhang, Huiying Wang, Yan Feng, Xueyan Wang, Hongtian Wang, Tianfei Lan, Meiling Liu, Xuefeng Wang, Yuemei Sun, Fangmei Luo…

    Citation: Clinical and Translational Allergy 2020 10:50

    Content type: Research

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  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Arunas Valiulis, J. Bousquet, A. Veryga, U. Suprun, D. Sergeenko, S. Cebotari, D. Borelli, S. Pietikainen, J. Banys, I. Agache, N. E. Billo, A. Bush, I. Chkhaidze, L. Dubey, W. J. Fokkens, J. Grigg…

    Citation: Clinical and Translational Allergy 2020 10:49

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2019 9:7

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Robert Boyle, Nick Brown, Wen Chin Chiang, Chua Mei Chien, Michael Gold, Jonathan Hourihane, Jane Peake, Patrick Quinn, Raj Rao, Peter Smith, Mimi Tang, John Ziegler and John Warner

    Citation: Clinical and Translational Allergy 2020 10:48

    Content type: Retraction Note

    Published on:

    The original article was published in Clinical and Translational Allergy 2015 5:P30

  10. An increase in online searches on health topics may either mirror epidemiological changes or reflect media coverage. In the context of COVID-19, this is particularly relevant, as COVID-19 symptoms may be mista...

    Authors: Bernardo Sousa-Pinto, Enrico Heffler, Aram Antó, Wienczyslawa Czarlewski, Anna Bedbrook, Bilun Gemicioglu, G. Walter Canonica, Josep M. Antó, João Almeida Fonseca and Jean Bousquet

    Citation: Clinical and Translational Allergy 2020 10:47

    Content type: Research

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  11. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivot...

    Authors: Tim Delemarre, Natalie De Ruyck, Gabriele Holtappels, Claus Bachert and Elien Gevaert

    Citation: Clinical and Translational Allergy 2020 10:41

    Content type: Letter to the Editor

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  12. Genome wide association studies (GWASs) have revealed several airway disease-associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic rhinosinusitis (CRS), however, is not yet...

    Authors: Anu Laulajainen-Hongisto, Annina Lyly, Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Risto Renkonen, Kati Donner, Pirkko Mattila, Tuomas Jartti, Jean Bousquet, Paula Kauppi and Sanna Toppila-Salmi

    Citation: Clinical and Translational Allergy 2020 10:45

    Content type: Review

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

    Citation: Clinical and Translational Allergy 2020 10:44

    Content type: Correction

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    The original article was published in Clinical and Translational Allergy 2020 10:16

  14. Allergic conjunctivitis (AC) is usually associated to allergic rhinitis (AR), but the severity and control of ocular symptoms should be assessed independently to improve diagnosis and treatment. The criteria f...

    Authors: M. Cesárea Sánchez-Hernández, Ana M. Navarro, Carlos Colás, Alfonso del Cuvillo, Joaquín Sastre, Joaquim Mullol and Antonio Valero

    Citation: Clinical and Translational Allergy 2020 10:43

    Content type: Research

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  15. Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls.

    Authors: Chunrong Huang, Youchao Yu, Wei Du, Yahui Liu, Ranran Dai, Wei Tang, Ping Wang, Chenhong Zhang and Guochao Shi

    Citation: Clinical and Translational Allergy 2020 10:42

    Content type: Research

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  16. Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare profes...

    Authors: Ekaterina Khaleva, Marta Vazquez-Ortiz, Pasquale Comberiati, Audrey DunnGalvin, Helena Pite, Katharina Blumchen, Teresa Garriga-Baraut, Valerie Hox, Alexandra F. Santos, Claudia Gore, Rebecca C. Knibb, Cherry Alviani, Charlotte G. Mortz, Elizabeth Angier, Bettina Duca, Britt Jensen…

    Citation: Clinical and Translational Allergy 2020 10:40

    Content type: Research

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  17. Treatment adherence greatly influences the clinical outcomes in various fields of medicine, including management of asthma and COPD. With the recent implementation of a nationwide e-Health solutions in Poland,...

    Authors: Grzegorz Kardas, Michał Panek, Piotr Kuna and Przemysław Kardas

    Citation: Clinical and Translational Allergy 2020 10:39

    Content type: Research

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  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Valerie Hox, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol…

    Citation: Clinical and Translational Allergy 2020 10:38

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2020 10:1

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: C. A. Akdis, J. Bousquet, C. E. Grattan, P. A. Eigenmann, K. Hofmann-Sommergruber, I. Agache and M. Jutel

    Citation: Clinical and Translational Allergy 2020 10:37

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2019 9:60

  20. The mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion tha...

    Authors: Lisa Pointner, Athanasios Bethanis, Michael Thaler, Claudia Traidl-Hoffmann, Stefanie Gilles, Fatima Ferreira and Lorenz Aglas

    Citation: Clinical and Translational Allergy 2020 10:36

    Content type: Review

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  21. Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited.

    Authors: Maryam A. Al-Nesf, Dorra Gharbi, Hassan M. Mobayed, Blessing Reena Dason, Ramzy Mohammed Ali, Salma Taha, Amjad Tuffaha, Mehdi Adeli, Hisham A. Sattar and Maria del Mar Trigo

    Citation: Clinical and Translational Allergy 2020 10:35

    Content type: Research

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  22. The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) a...

    Authors: Fariza Mishaal Saiema Badloe, Shauni De Vriese, Katarina Coolens, Carsten B. Schmidt-Weber, Johannes Ring, Jan Gutermuth and Inge Kortekaas Krohn

    Citation: Clinical and Translational Allergy 2020 10:34

    Content type: Review

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  23. Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-...

    Authors: D. Ferastraoaru, H. J. Bax, C. Bergmann, M. Capron, M. Castells, D. Dombrowicz, E. Fiebiger, H. J. Gould, K. Hartmann, U. Jappe, G. Jordakieva, D. H. Josephs, F. Levi-Schaffer, V. Mahler, A. Poli, D. Rosenstreich…

    Citation: Clinical and Translational Allergy 2020 10:32

    Content type: Review

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  24. One of the important pathogeneses of eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence of allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on th...

    Authors: Yun Ma, Maojin Liang, Peng Tian, Xiang Liu, Hua Dang, Qiujian Chen, Hua Zou and Yiqing Zheng

    Citation: Clinical and Translational Allergy 2020 10:30

    Content type: Research

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  25. Emerging data indicates that extracellular traps (ETs), structures formed by various immune cell types, may contribute to the pathology of noninfectious inflammatory diseases. Histone hypercitrullination is an...

    Authors: Pawel Kuczia, Joanna Zuk, Teresa Iwaniec, Jerzy Soja, Jerzy Dropinski, Marta Malesa-Wlodzik, Lech Zareba, Jan G. Bazan, Anetta Undas and Stanislawa Bazan-Socha

    Citation: Clinical and Translational Allergy 2020 10:31

    Content type: Research

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  26. Farmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respirator...

    Authors: T. Sigsgaard, I. Basinas, G. Doekes, F. de Blay, I. Folletti, D. Heederik, A. Lipinska-Ojrzanowska, D. Nowak, M. Olivieri, S. Quirce, M. Raulf, J. Sastre, V. Schlünssen, J. Walusiak-Skorupa and A. Siracusa

    Citation: Clinical and Translational Allergy 2020 10:29

    Content type: Review

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  27. Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid as...

    Authors: Ming Wang, Xiangting Bu, Ge Luan, Liqing Lin, Yang Wang, Jianmin Jin, Luo Zhang and Chengshuo Wang

    Citation: Clinical and Translational Allergy 2020 10:26

    Content type: Research

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  28. House dust mite (HDM) allergens constitute the most frequent cause of persistent allergic rhinitis and asthma. The symptoms vary throughout the year but typically peak in spring, autumn and (to a lesser extent...

    Authors: Pascal Demoly, Andrea Matucci, Oliviero Rossi and Carmen Vidal

    Citation: Clinical and Translational Allergy 2020 10:27

    Content type: Research

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  29. Concerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use...

    Authors: V. Mahler, D. Mentzer, A. Bonertz, A. Muraro, P. Eigenmann, J. Bousquet, S. Halken, O. Pfaar, M. Jutel, U. Wahn, S. Vieths and S. Kaul

    Citation: Clinical and Translational Allergy 2020 10:28

    Content type: Review

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  30. A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis with nasal polyps (CRSwNP), the presence of which may adversely...

    Authors: Enrico Heffler, Fabiana Saccheri, Marta Bartezaghi and Giorgio Walter Canonica

    Citation: Clinical and Translational Allergy 2020 10:25

    Content type: Research

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  31. In December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the F...

    Authors: Jean Bousquet, Josep M. Anto, Tari Haahtela, Pekka Jousilahti, Marina Erhola, Xavier Basagaña, Wienczyslawa Czarlewski, Mikaëla Odemyr, Susanna Palkonen, Mikael Sofiev, César Velasco, Anna Bedbrook, Rodrigo Delgado, Rostislav Kouznetsov, Mika Mäkelä, Yuliia Palamarchuk…

    Citation: Clinical and Translational Allergy 2020 10:24

    Content type: Review

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  32. Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

    Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti

    Citation: Clinical and Translational Allergy 2020 10:23

    Content type: Review

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  33. Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic protei...

    Authors: Claudia Alessandri, Rosetta Ferrara, Maria Livia Bernardi, Danila Zennaro, Lisa Tuppo, Ivana Giangrieco, Teresa Ricciardi, Maurizio Tamburrini, Maria Antonietta Ciardiello and Adriano Mari

    Citation: Clinical and Translational Allergy 2020 10:22

    Content type: Review

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  34. Intramuscular (IM) injection of epinephrine (adrenaline) at the mid-anterolateral (AL) thigh is the international standard therapy for acute anaphylaxis. Concerns exist regarding implications of epinephrine au...

    Authors: Margitta Worm, DucTung Nguyen, Russ Rackley, Antonella Muraro, George Du Toit, Tracey Lawrence, Hong Li, Kurt Brumbaugh and Magnus Wickman

    Citation: Clinical and Translational Allergy 2020 10:21

    Content type: Research

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  35. New recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. These recommendations provide very important changes to the management of asthma, especi...

    Authors: Izabela Kuprys-Lipinska, Marta Kolacinska-Flont and Piotr Kuna

    Citation: Clinical and Translational Allergy 2020 10:19

    Content type: Review

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  36. Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. Malassezia globosa, a skin resident fungus...

    Authors: Sabine Altrichter, Pia Schumacher, Ola Alraboni, Yiyu Wang, Makiko Hiragun, Michihiro Hide and Marcus Maurer

    Citation: Clinical and Translational Allergy 2020 10:18

    Content type: Research

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  37. Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later lif...

    Authors: Giovanni A. Rossi, Petr Pohunek, Wojciech Feleszko, Stefania Ballarini and Andrew A. Colin

    Citation: Clinical and Translational Allergy 2020 10:17

    Content type: Review

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  38. Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most curren...

    Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

    Citation: Clinical and Translational Allergy 2020 10:16

    Content type: Review

    Published on:

    The Correction to this article has been published in Clinical and Translational Allergy 2020 10:44

  39. Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited.

    Authors: Erik Melén, Anna Bergström, Inger Kull, Catarina Almqvist, Niklas Andersson, Anna Asarnoj, Magnus P. Borres, Antonis Georgellis, Göran Pershagen, Marit Westman, Marianne van Hage and Natalia Ballardini

    Citation: Clinical and Translational Allergy 2020 10:15

    Content type: Research

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  40. The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources ...

    Authors: Kitty Verhoeckx, Katrine Lindholm Bøgh, Anne Constable, Michelle M. Epstein, Karin Hoffmann Sommergruber, Thomas Holzhauser, Geert Houben, Annette Kuehn, Erwin Roggen, Liam O’Mahony, Ben Remington and René Crevel

    Citation: Clinical and Translational Allergy 2020 10:13

    Content type: Review

    Published on:

  41. Worldwide, guidelines recommend the use of adrenaline autoinjectors (AAIs) for self-medication in patients who experience severe allergic reaction. The European Medical Agency recommends the prescription of tw...

    Authors: Magdalena Kraft, Sabine Dölle-Bierke, Paul J. Turner, Antonella Muraro, Montserrat Fernández-Rivas, Linus Grabenhenrich and Margitta Worm

    Citation: Clinical and Translational Allergy 2020 10:12

    Content type: Research

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  42. Allergen immunotherapy (AIT) is the only treatment option available for allergic patients with disease-modifying intention. Both efficacy and safety has been demonstrated for multiple trials in children, adole...

    Authors: O. Pfaar, R. Gerth van Wijk, L. Klimek, J. Bousquet and P. S. Creticos

    Citation: Clinical and Translational Allergy 2020 10:11

    Content type: Review

    Published on:

  43. Pollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previou...

    Authors: Thomas Proctor, Elodie Morrough, Otto Fenske, Sarah Allatt, Stephen M. Hughes, Vibha Sharma and Peter D. Arkwright

    Citation: Clinical and Translational Allergy 2020 10:10

    Content type: Research

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  44. Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.

    Authors: Dimitrios I. Mitsias, Maria V. Dimou, John Lakoumentas, Konstantinos Alevizopoulos, Bernardo Sousa-Pinto, Joao A. Fonseca, Jean Bousquet and Nikolaos G. Papadopoulos

    Citation: Clinical and Translational Allergy 2020 10:9

    Content type: Research

    Published on:

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