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  1. Study protocol

    An open-label study to evaluate the long-term safety and efficacy of lanadelumab for prevention of attacks in hereditary angioedema: design of the HELP study extension

    Hereditary angioedema (HAE) is characterized by recurrent attacks of subcutaneous or submucosal edema. Attacks are unpredictable, debilitating, and have a significant impact on quality of life. Patients may be...

    Marc A. Riedl, Jonathan A. Bernstein, Timothy Craig, Aleena Banerji, Markus Magerl, Marco Cicardi, Hilary J. Longhurst, Mustafa M. Shennak, William H. Yang, Jennifer Schranz, Jovanna Baptista and Paula J. Busse

    Clinical and Translational Allergy 2017 7:36

    Published on: 6 October 2017

  2. Research

    The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow’s milk- and peanut allergy models

    Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow’s milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety.

    Marlotte M. Vonk, Laura Wagenaar, Raymond H. H. Pieters, Leon M. J. Knippels, Linette E. M. Willemsen, Joost J. Smit, Betty C. A. M. van Esch and Johan Garssen

    Clinical and Translational Allergy 2017 7:35

    Published on: 29 September 2017

  3. Editorial

    An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care

    General Practitioners suffer from guideline fatigue. They come fast and furious in many complicated forms. Cow’s milk allergy (CMA) is one of the most common presentations of food allergy seen in early childho...

    Paul Netts and Louise J. Michaelis

    Clinical and Translational Allergy 2017 7:34

    Published on: 22 September 2017

    The original article was published in Clinical and Translational Allergy 2017 7:26

  4. Research

    Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA2LEN study

    The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used...

    Georg Boelke, Uwe Berger, Karl-Christian Bergmann, Carsten Bindslev-Jensen, Jean Bousquet, Julia Gildemeister, Marek Jutel, Oliver Pfaar, Torsten Sehlinger and Torsten Zuberbier

    Clinical and Translational Allergy 2017 7:33

    Published on: 17 September 2017

  5. Erratum

    Erratum to: Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela…

    Clinical and Translational Allergy 2017 7:31

    Published on: 15 September 2017

    The original article was published in Clinical and Translational Allergy 2016 6:24

  6. Erratum

    Erratum to: Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…

    Clinical and Translational Allergy 2017 7:29

    Published on: 15 September 2017

    The original article was published in Clinical and Translational Allergy 2016 6:12

  7. Erratum

    Erratum to: Allergen immunotherapy for insect venom allergy: protocol for a systematic review

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A. Akdis, Darío Antolín-Amérigo, M. Beatrice Bilò, Danijela Bokanovic, Moises A. Calderon, Ewa Cichocka-Jarosz, Joanna N. G. Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange…

    Clinical and Translational Allergy 2017 7:30

    Published on: 15 September 2017

    The original article was published in Clinical and Translational Allergy 2016 6:6

  8. Erratum

    Erratum to: Allergen immunotherapy for allergic asthma: protocol for a systematic review

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann…

    Clinical and Translational Allergy 2017 7:32

    Published on: 15 September 2017

    The original article was published in Clinical and Translational Allergy 2016 6:5

  9. Brief communication

    Idiopathic non-histaminergic acquired angioedema: a case series and discussion of published clinical trials

    Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatm...

    Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling and Urs Christian Steiner

    Clinical and Translational Allergy 2017 7:27

    Published on: 31 August 2017

  10. Review

    Better recognition, diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy: iMAP—an international interpretation of the MAP (Milk Allergy in Primary Care) guideline

    Cow’s milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as we...

    Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M. Fleischer, Ralf G. Heine, Michael Levin, Mario C. Vieira and Adam T. Fox

    Clinical and Translational Allergy 2017 7:26

    Published on: 23 August 2017

    The original article was published in Clinical and Translational Allergy 2017 7:34

  11. Meeting abstracts

    Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)

    Ibon Eguiluz Gracia, Carmen Rondón, Paloma Campo, Ana Prieto, Lina Mayorga, Luisa Galindo, Ana Molina, Miguel Blanca, Maria Jose Torres, Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Shigeharu Fujieda, Tomohiro Yoshimoto, Naruhito Iwasaki, Tamar Smulders…

    Clinical and Translational Allergy 2017 7(Suppl 3):28

    Published on: 23 August 2017

    This article is part of a Supplement: Volume 7 Supplement 3

  12. Review

    Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic overview of systematic reviews

    The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we...

    Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Stephen Durham, Roy Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…

    Clinical and Translational Allergy 2017 7:24

    Published on: 8 August 2017

  13. Review

    Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews

    There is clinical uncertainty about the effectiveness and safety of allergen immunotherapy (AIT) for the treatment of allergic asthma.

    Felix Asamoah, Artemisia Kakourou, Sangeeta Dhami, Susanne Lau, Ioana Agache, Antonella Muraro, Graham Roberts, Cezmi Akdis, Matteo Bonini, Ozlem Cavkaytar, Breda Flood, Kenji Izuhara, Marek Jutel, Ömer Kalayci, Oliver Pfaar and Aziz Sheikh

    Clinical and Translational Allergy 2017 7:25

    Published on: 2 August 2017

  14. Brief communication

    National clinical practice guidelines for food allergy and anaphylaxis: an international assessment

    Clinical practice guidelines are important tools to promote evidence-based clinical care, but not all countries have the capacity or infrastructure to develop these in-house. The European Academy of Allergy an...

    Asiyah Sheikh, Zakariya Sheikh, Graham Roberts, Antonella Muraro, Sangeeta Dhami and Aziz Sheikh

    Clinical and Translational Allergy 2017 7:23

    Published on: 25 July 2017

  15. Review

    Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures

    Diagnostic tests to detect allergic sensitization were introduced at the end of the nineteenth century but only in the late 1990s did the advent of molecular allergology revolutionize the approach to the aller...

    C. Alessandri, R. Ferrara, M. L. Bernardi, D. Zennaro, L. Tuppo, I. Giangrieco, M. Tamburrini, A. Mari and M. A. Ciardiello

    Clinical and Translational Allergy 2017 7:21

    Published on: 17 July 2017

  16. Review

    Endotype-driven treatment in chronic upper airway diseases

    Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total popula...

    Glynnis De Greve, Peter W. Hellings, Wytske J. Fokkens, Benoit Pugin, Brecht Steelant and Sven F. Seys

    Clinical and Translational Allergy 2017 7:22

    Published on: 12 July 2017

  17. Research

    Health Related Quality of Life among schoolchildren aged 12–13 years in relation to food hypersensitivity phenotypes: a population-based study

    While Health Related Quality of Life has been investigated among children with IgE-mediated food allergy, less is known about quality of life among children with other types of hypersensitivity to food. The ai...

    Åsa Strinnholm, Linnéa Hedman, Anna Winberg, Sven-Arne Jansson, Viveca Lindh and Eva Rönmark

    Clinical and Translational Allergy 2017 7:20

    Published on: 3 July 2017

  18. Letter to the Editor

    Food allergy in a child with de novo KAT6A mutation

    Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is...

    Varpu Elenius, Tuire Lähdesmäki, Marja Hietala and Tuomas Jartti

    Clinical and Translational Allergy 2017 7:19

    Published on: 22 June 2017

  19. Research

    The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study

    Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration...

    Tanly Su, Berna D. L. Broekhuizen, Theo J. M. Verheij and Heike Rockmann

    Clinical and Translational Allergy 2017 7:18

    Published on: 7 June 2017

  20. Review

    Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

    This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is t...

    C. Cingi, P. Gevaert, R. Mösges, C. Rondon, V. Hox, M. Rudenko, N. B. Muluk, G. Scadding, F. Manole, C. Hupin, W. J. Fokkens, C. Akdis, C. Bachert, P. Demoly, J. Mullol, A. Muraro…

    Clinical and Translational Allergy 2017 7:17

    Published on: 1 June 2017

  21. Meeting abstracts

    Abstracts from the 3rd International Severe Asthma Forum (ISAF)

    M. E. Ketelaar, K. Van De Kant, F. N. Dijk, E. M. M. Klaassen, N. Grotenboer, M. C. Nawijn, E. Dompeling, G. H. Koppelman, Clare Murray, Philip Foden, Lesley Lowe, Hannah Durrington, Adnan Custovic, Angela Simpson, Andrew J. Simpson, Dominick E. Shaw…

    Clinical and Translational Allergy 2017 7(Suppl 2):14

    Published on: 24 May 2017

    This article is part of a Supplement: Volume 7 Supplement 2

  22. Review

    Quality indicators for the acute and long-term management of anaphylaxis: a systematic review

    The quality of acute and long-term anaphylaxis management is variable and this contributes to the poor outcomes experienced by many patients. Clinical practice guidelines have the potential to improve outcomes...

    Sangeeta Dhami, Aadam Sheikh, Antonella Muraro, Graham Roberts, Susanne Halken, Monserat Fernandez Rivas, Margitta Worm and Aziz Sheikh

    Clinical and Translational Allergy 2017 7:15

    Published on: 24 May 2017

  23. Review

    Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

    The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing...

    Jolanda H. M. van Bilsen, Edyta Sienkiewicz-Szłapka, Daniel Lozano-Ojalvo, Linette E. M. Willemsen, Celia M. Antunes, Elena Molina, Joost J. Smit, Barbara Wróblewska, Harry J. Wichers, Edward F. Knol, Gregory S. Ladics, Raymond H. H. Pieters, Sandra Denery-Papini, Yvonne M. Vissers, Simona L. Bavaro, Colette Larré…

    Clinical and Translational Allergy 2017 7:13

    Published on: 12 May 2017

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