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  1. Rhinovirus A and C infections are important contributors to asthma induction and exacerbations. No data exist on the interaction of local immune responses in rhinovirus infection. Therefore, we aimed to determ...

    Authors: Emilia Mikola, Oscar Palomares, Riitta Turunen, Matti Waris, Lotta E. Ivaska, Antti Silvoniemi, Tuomo Puhakka, Beate Rückert, Tytti Vuorinen, Mübeccel Akdis, Cezmi A. Akdis and Tuomas Jartti

    Citation: Clinical and Translational Allergy 2019 9:63

    Content type: Research

    Published on:

  2. The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress inflammatory responses in different cells. In this study,...

    Authors: Anet Kivihall, Alar Aab, Jerzy Soja, Krzysztof Sładek, Marek Sanak, Alan Altraja, Bogdan Jakiela, Grazyna Bochenek and Ana Rebane

    Citation: Clinical and Translational Allergy 2019 9:62

    Content type: Research

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  3. Our meta-analysis of several ethnic groups (Japanese, Korean, Indian, Brazilian) revealed a significant genome-wide association between cold medicine-related SJS/TEN (CM-SJS/TEN) with severe ocular complicatio...

    Authors: Patchima Chantaren, Passara Jongkhajornpong, Mayumi Ueta, Vilavun Puangsricharern, Kaevalin Lekhanont, Phattrawan Pisuchpen, Pinnita Prabhasawat, Kanya Suphapeetiporn and Shigeru Kinoshita

    Citation: Clinical and Translational Allergy 2019 9:61

    Content type: Research letter

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  4. The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI inclu...

    Authors: C. A. Akdis, J. Bousquet, C. E. Grattan, P. A. Eigenmann, K. Hoffmann-Sommergruber, I. Agache and M. Jutel

    Citation: Clinical and Translational Allergy 2019 9:60

    Content type: Review

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  5. This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe ...

    Authors: Louise Parke, Annemarie Schaeffer Senders, Carsten Bindslev-Jensen, Annmarie Touborg Lassen, Athamaica Ruiz Oropeza, Susanne Halken, Sigurd Broesby-Olsen, Henrik Fomsgaard Kjær and Charlotte G. Mortz

    Citation: Clinical and Translational Allergy 2019 9:59

    Content type: Research Letter

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  6. Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the...

    Authors: C. Nitsche, C. D. Westerlaken-van Ginkel, B. J. Kollen, A. B. Sprikkelman, G. H. Koppelman and A. E. J. Dubois

    Citation: Clinical and Translational Allergy 2019 9:58

    Content type: Letter to the Editor

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  7. The Nature Step to Respiratory Health was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed t...

    Authors: Tari Haahtela, Leena von Hertzen, Josep M. Anto, Chunxue Bai, Abay Baigenzhin, Eric D. Bateman, Digambar Behera, Kazi Bennoor, Paulo Camargos, Niels Chavannes, Jaime Correia de Sousa, Alvaro Cruz, Maria Do Céu Teixeira, Marina Erhola, Eeva Furman, Bilun Gemicioğlu…

    Citation: Clinical and Translational Allergy 2019 9:57

    Content type: Review

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  8. Temporal ecological studies have shown that outdoor moulds are associated with severe asthma exacerbations, as emergency department visits or hospitalisations. The aim of this was to assess the associations be...

    Authors: D. M. Caillaud, S. Martin, C. Ségala, N. Dupuy, M. Thibaudon and D. Muti

    Citation: Clinical and Translational Allergy 2019 9:56

    Content type: Letter to the Editor

    Published on:

  9. Hymenoptera stings are a major cause of anaphylaxis. Various risk factors are discussed in literature. This study aims to investigate potential risk factors for severe sting reactions in wasp (Vespula spp.) and h...

    Authors: Danielle Fehr, Sara Micaletto, Thomas Moehr and Peter Schmid-Grendelmeier

    Citation: Clinical and Translational Allergy 2019 9:54

    Content type: Research

    Published on:

  10. Following publication of the original article [1], the authors reported that one of the authors’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author...

    Authors: J. Bousquet and M. van Hage

    Citation: Clinical and Translational Allergy 2019 9:53

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2016 6:47

  11. Following publication of the original article [1], the authors reported that one of the collaborators’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the ...

    Authors: J. Bousquet

    Citation: Clinical and Translational Allergy 2019 9:52

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2019 9:16

  12. Following publication of the original article [1], the authors reported that one of the collaborators’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the ...

    Authors: J. Bousquet

    Citation: Clinical and Translational Allergy 2019 9:51

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2018 8:45

  13. Different clinical trials showed the superior efficacy of rupatadine compared to placebo at improving seasonal allergic rhinitis (SAR) symptoms, but no study has assessed if the response promoted is clinically...

    Authors: Joaquim Mullol, Iñaki Izquierdo, Kimihiro Okubo, Giorgio Walter Canonica, Jean Bousquet and Antonio Valero

    Citation: Clinical and Translational Allergy 2019 9:50

    Content type: Research

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  14. Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monoc...

    Authors: Hua Peng, Jian Wang, Xiao Yan Ye, Jie Cheng, Cheng Zhi Huang, Li Yue Li, Tian Ying Li and Chun Wei Li

    Citation: Clinical and Translational Allergy 2019 9:49

    Content type: Letter to the Editor

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  15. Chronic urticaria is a disease characterized by the appearance of weals, angioedema or both longer than 6 weeks. Degranulation of cutaneous or submucosal mast cells leads to release of mediators including hist...

    Authors: Emek Kocatürk and Clive Grattan

    Citation: Clinical and Translational Allergy 2019 9:48

    Content type: Review

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  16. Recurrent use of oral corticosteroids (OCS) and over-use of short-acting beta-2-agonists (SABA) are factors associated with adverse side effects and asthma-related death. We aim to quantify high OCS exposure, ...

    Authors: Ana Sá-Sousa, Rute Almeida, Ricardo Vicente, Nilton Nascimento, Henrique Martins, Alberto Freitas and João Almeida Fonseca

    Citation: Clinical and Translational Allergy 2019 9:47

    Content type: Research

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  17. Recommendations on contraindications to allergen immunotherapy (AIT) have been independently developed by National and International Societies/Academies. AIT contraindications are mainly based on case reports,...

    Authors: C. Pitsios, M. Tsoumani, M. B. Bilò, G. J. Sturm, P. Rodríguez del Río, R. Gawlik, F. Ruëff, G. Paraskevopoulos, E. Valovirta, O. Pfaar, M. A. Calderón and P. Demoly

    Citation: Clinical and Translational Allergy 2019 9:45

    Content type: Review

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  18. In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support th...

    Authors: J. Jean Bousquet, Holger J. Schünemann, Alkis Togias, Marina Erhola, Peter W. Hellings, Torsten Zuberbier, Ioana Agache, Ignacio J. Ansotegui, Josep M. Anto, Claus Bachert, Sven Becker, Martin Bedolla-Barajas, Michael Bewick, Sinthia Bosnic-Anticevich, Isabelle Bosse, Louis P. Boulet…

    Citation: Clinical and Translational Allergy 2019 9:44

    Content type: Review

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  19. Asthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA2LEN) que...

    Authors: Afshin Ostovar, Wytske J. Fokkens, Safoora Pordel, Ali Movahed, Khadijeh Ghasemi, Maryam Marzban and Shokrollah Farrokhi

    Citation: Clinical and Translational Allergy 2019 9:43

    Content type: Research

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  20. Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship...

    Authors: David B. Price, Sinthia Bosnic-Anticevich, Ian D. Pavord, Nicolas Roche, David M. G. Halpin, Leif Bjermer, Omar S. Usmani, Guy Brusselle, Simon Wan Yau Ming and Sarang Rastogi

    Citation: Clinical and Translational Allergy 2019 9:41

    Content type: Research

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  21. The Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps be...

    Authors: Adam Fox, Trevor Brown, Joanne Walsh, Carina Venter, Rosan Meyer, Anna Nowak-Wegrzyn, Michael Levin, Hannah Spawls, Jolene Beatson, Marie-Therese Lovis, Mario C. Vieira and David Fleischer

    Citation: Clinical and Translational Allergy 2019 9:40

    Content type: Letter to the Editor

    Published on:

  22. In two independent microarray studies involving primary airway epithelial cells, the relative gene expression of TMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for fu...

    Authors: Naiya B. Patel, Lorena A. Ostilla, Lyda Cuervo-Pardo, Sergejs Berdnikovs and Sergio E. Chiarella

    Citation: Clinical and Translational Allergy 2019 9:38

    Content type: Letter to the Editor

    Published on:

  23. This multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14–55 years and had allergic rhinitis and/or asthma, which was due...

    Authors: Beristain Ana and Fernando de la Torre

    Citation: Clinical and Translational Allergy 2019 9:39

    Content type: Research letter

    Published on:

  24. Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and co...

    Authors: Polliana Mihaela Leru

    Citation: Clinical and Translational Allergy 2019 9:36

    Content type: Review

    Published on:

  25. Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling in subcutaneous or submucosal tissues. Symptoms often begin by age 5–11 years and worsen during puberty, b...

    Authors: Anette Bygum, Teresa Caballero, Anete S. Grumach, Hilary J. Longhurst, Laurence Bouillet, Werner Aberer, Andrea Zanichelli, Jaco Botha, Irmgard Andresen and Marcus Maurer

    Citation: Clinical and Translational Allergy 2019 9:37

    Content type: Research

    Published on:

  26. Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of ...

    Authors: Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park and Young-Min Ye

    Citation: Clinical and Translational Allergy 2019 9:33

    Content type: Research

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  27. Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients...

    Authors: Zonne L. M. Hofman, Nikki van West, C. Erik Hack, André C. Knulst, Coen Maas and Heike Röckmann

    Citation: Clinical and Translational Allergy 2019 9:35

    Content type: Letter to the Editor

    Published on:

  28. The atopic syndrome consists of heterogeneous manifestations, in which multiple associated genetic loci have recently been identified. It is hypothesized that immune dysregulation plays a role in the pathogene...

    Authors: Jill de Wit, Rogier T. A. van Wijck, Virgil A. S. H. Dalm, Kristen L. Snyder, Joan E. E. Totté, Suzanne G. M. A. Pasmans and Peter J. van der Spek

    Citation: Clinical and Translational Allergy 2019 9:34

    Content type: Research

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  29. The objective of this analysis was to compare the multiplex ImmunoCAP ISAC (Thermo Fisher Scientific, Sweden) and the multiplex Alex Allergy Explorer (Macro Array Diagnostics GmbH, Austria) platform on specifi...

    Authors: Jana Bojcukova, Tomas Vlas, Peter Forstenlechner and Petr Panzner

    Citation: Clinical and Translational Allergy 2019 9:31

    Content type: Research

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  30. In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are ...

    Authors: Anna M. Ehlers, Madlen Rossnagel, Bettina Brix, Mark A. Blankestijn, Thuy-My Le, Waltraud Suer, Henny G. Otten and André C. Knulst

    Citation: Clinical and Translational Allergy 2019 9:32

    Content type: Letter to the Editor

    Published on:

  31. Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical tre...

    Authors: Lien Calus, Nicholas Van Bruaene, Cedric Bosteels, Sarah Dejonckheere, Thibaut Van Zele, Gabrielle Holtappels, Claus Bachert and Philippe Gevaert

    Citation: Clinical and Translational Allergy 2019 9:30

    Content type: Research

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  32. Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates th...

    Authors: Ralph Mösges, Antonio Valero Santiago, Silke Allekotte, Nilufar Jahed, Anatoli Astvatsatourov, Angelika Sager and Jaime Sánchez-López

    Citation: Clinical and Translational Allergy 2019 9:29

    Content type: Review

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  33. Altered gut microbiota is implicated in cow’s milk allergy (CMA) and differs markedly from healthy, breastfed infants. Infants who suffer from severe CMA often rely on cow’s milk protein avoidance and, when br...

    Authors: Harm Wopereis, Marleen T. J. van Ampting, Aysun Cetinyurek-Yavuz, Rob Slump, David C. A. Candy, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, Adam T. Fox, Neil Shah, Guus Roeselers, Lucien F. Harthoorn, Louise J. Michaelis, Jan Knol and Christina E. West

    Citation: Clinical and Translational Allergy 2019 9:27

    Content type: Research

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  34. The identification of house dust mite (HDM) allergens and epitopes is important for allergy diagnosis and treatment. We sought to identify the Dermatophagoides pteronyssinus group 24 allergen (Der p 24) and to id...

    Authors: Ze-Lang Cai, Jia-Jie Chen, Zhen Zhang, Yi-Bo Hou, Yong-shen He, Jin-Lyu Sun and Kunmei Ji

    Citation: Clinical and Translational Allergy 2019 9:28

    Content type: Research

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  35. The clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recomm...

    Authors: Morten J. Christensen, Esben Eller, Charlotte G. Mortz, Knut Brockow and Carsten Bindslev-Jensen

    Citation: Clinical and Translational Allergy 2019 9:26

    Content type: Letter to the Editor

    Published on:

  36. Adverse psychosocial working conditions—in particular poor job decision latitude and poor social support at work—may impair the effective implementation of asthma self-management behaviour at work and may be a...

    Authors: Katherina Heinrichs, Stefan Hummel, Jalal Gholami, Konrad Schultz, Jian Li, Aziz Sheikh and Adrian Loerbroks

    Citation: Clinical and Translational Allergy 2019 9:25

    Content type: Research

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  37. Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive...

    Authors: Katrine Y. Baumann, Martin K. Church, Geraldine F. Clough, Sven Roy Quist, Martin Schmelz, Per Stahl Skov, Chris D. Anderson, Line Kring Tannert, Ana Maria Giménez-Arnau, Stefan Frischbutter, Jörg Scheffel and Marcus Maurer

    Citation: Clinical and Translational Allergy 2019 9:24

    Content type: Review

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  38. Following publication of the original article [1], the authors reported that one of the authors’ name was spelled incorrectly.

    Authors: Filip Raciborski, Jean Bousquet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z. Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska…

    Citation: Clinical and Translational Allergy 2019 9:23

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Allergy 2019 9:4

  39. The prevalence of self-experienced adverse reactions to foods seems to have an increasing trend in both adults and children. However, it is unclear if the prevalence of food hypersensitivity in the Swedish adu...

    Authors: G. Rentzos, L. Johanson, Emma Goksör, E. Telemo, Bo Lundbäck and L. Ekerljung

    Citation: Clinical and Translational Allergy 2019 9:22

    Content type: Research

    Published on:

  40. Evidence from observational comparative effectiveness research (CER) is ranked below that from randomized controlled trials in traditional evidence hierarchies. However, asthma observational CER studies repre...

    Authors: Jonathan D. Campbell, Robert Perry, Nikolaos G. Papadopoulos, Jerry Krishnan, Guy Brusselle, Alison Chisholm, Leif Bjermer, Michael Thomas, Eric van Ganse, Maarten van den Berge, Jennifer Quint, David Price and Nicolas Roche

    Citation: Clinical and Translational Allergy 2019 9:21

    Content type: Research

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  41. A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observa...

    Authors: Nicolas Roche, Jonathan D. Campbell, Jerry A. Krishnan, Guy Brusselle, Alison Chisholm, Leif Bjermer, Mike Thomas, Eric van Ganse, Maarten van den Berge, George Christoff, Jennifer Quint, Nikolaos G. Papadopoulos and David Price

    Citation: Clinical and Translational Allergy 2019 9:20

    Content type: Research

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  42. In wheat-dependent exercise-induced anaphylaxis (WDEIA), cofactors such as exercise, acetylsalicylic acid (ASA), alcohol or unfavorable climatic conditions are required to elicit a reaction to wheat products. ...

    Authors: Katharina Anne Scherf, Ann-Christin Lindenau, Luzia Valentini, Maria Carmen Collado, Izaskun García-Mantrana, Morten Christensen, Dirk Tomsitz, Claudia Kugler, Tilo Biedermann and Knut Brockow

    Citation: Clinical and Translational Allergy 2019 9:19

    Content type: Research

    Published on:

  43. The correct classification of an adverse drug reaction (ADR) as allergy (immunological) or intolerance (non-immunological) has important clinical implications. The aim of this study was to examine the ability ...

    Authors: Sepehr Shakib, Gillian E. Caughey, Jie Shen Fok and William B. Smith

    Citation: Clinical and Translational Allergy 2019 9:18

    Content type: Research

    Published on:

  44. Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approa...

    Authors: Rita Amaral, Ana M. Pereira, Tiago Jacinto, Andrei Malinovschi, Christer Janson, Kjell Alving and João A. Fonseca

    Citation: Clinical and Translational Allergy 2019 9:17

    Content type: Research

    Published on:

  45. Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multi...

    Authors: J. Bousquet, A. Bedbrook, W. Czarlewski, G. L. Onorato, S. Arnavielhe, D. Laune, E. Mathieu-Dupas, J. Fonseca, E. Costa, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, M. Illario, E. Menditto, G. W. Canonica, L. Cecchi…

    Citation: Clinical and Translational Allergy 2019 9:16

    Content type: Review

    Published on:

    The Correction to this article has been published in Clinical and Translational Allergy 2019 9:52

  46. Cosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since all...

    Authors: Karolina Dumycz, Katarzyna Kunkiel and Wojciech Feleszko

    Citation: Clinical and Translational Allergy 2019 9:15

    Content type: Letter to the Editor

    Published on:

  47. The distribution of Pooideae species varies across Europe. Especially, Timothy is less represented in Southern than in Northern Europe. Since allergenic cross-reactivity between pollens from different grasses ...

    Authors: Thierry Batard, Amparo Sanjuan, Laure Denis, Hélène Nguyen, Armelle Montagut, Joaquín Sastre, Sabina Rak and Jean F. Cuiné

    Citation: Clinical and Translational Allergy 2019 9:13

    Content type: Research

    Published on:

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