Articles

Normocomplementaemic urticarial vasculitis: effective treatment with omalizumab

We report two patients with normocomplementaemic urticarial vasculitis with impressive response to omalizumab. This contrasts recent reports on hypocomplementaemic urticarial vasculitis syndrome, highlighting ...

Authors: Marianne de Brito, Gisela Huebner, DedeeF Murrell, Peter Bullpitt and Karin Hartmann

POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project

Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, As...

Authors: Jean Bousquet, Josep M. Anto, Isabella Annesi-Maesano, Toni Dedeu, Eve Dupas, Jean-Louis Pépin, Landry Stephane Zeng Eyindanga, Sylvie Arnavielhe, Julia Ayache, Xavier Basagana, Samuel Benveniste, Nuria Calves Venturos, Hing Kin Chan, Mehdi Cheraitia, Yves Dauvilliers, Judith Garcia-Aymerich…

Calu-3 epithelial cells exhibit different immune and epithelial barrier responses from freshly isolated primary nasal epithelial cells in vitro

Epithelial cell lines are often used to evaluate the effect of exogenous/endogenous stimuli on epithelial barrier function and innate immune responses in allergic airway diseases, without clear view on differe...

Authors: Katleen Martens, Peter W. Hellings and Brecht Steelant

Visual analogue scale for sino-nasal symptoms severity correlates with sino-nasal outcome test 22: paving the way for a simple outcome tool of CRS burden

A visual analogue scale (VAS) is a psychometric instrument widely used in the Rhinology field to subjectively quantify patient’s symptoms severity. In allergic rhinitis, VAS has been found to correlate well wi...

Authors: Maria Doulaptsi, Emmanuel Prokopakis, Sven Seys, Benoit Pugin, Brecht Steelant and Peter Hellings

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

Authors:

Promoting and achieving excellence in the delivery of Integrated Allergy Care: the European Academy of Allergy & Clinical Immunology competencies for allied health professionals working in allergy

The multi-disciplinary team approach is an effective model for patient care. Allied health professionals (AHPs) are an important part of such teams, bringing specific knowledge and skills related to the target...

Authors: I. J. Skypala, N. W. de Jong, E. Angier, J. Gardner, I. Kull, D. Ryan, C. Venter, B. J. Vlieg-Boerstra and K. Grimshaw

Maternal exposure to farming environment protects offspring against allergic diseases by modulating the neonatal TLR-Tregs-Th axis

As the development of urbanization in China, the morbidity of allergic disease rise up prominently even in children, which may be partially associated with the excessively clean environment. It has been report...

Authors: Jinyan Yu, Xiaoqiu Liu, Yanlei Li, Shanshan Meng, Fei Wu, Bingdi Yan, Yanjun Xue, Tiangang Ma, Junling Yang and Jing Liu

Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure

Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has ...

Authors: Jaap Akkerdaas, Muriel Totis, Brian Barnett, Erin Bell, Tom Davis, Thomas Edrington, Kevin Glenn, Gerson Graser, Rod Herman, Andre Knulst, Gregory Ladics, Scott McClain, Lars K. Poulsen, Rakesh Ranjan, Jean-Baptiste Rascle, Hector Serrano…

Assessing severity of anaphylaxis: a data-driven comparison of 23 instruments

The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity...

Authors: Esben Eller, Antonella Muraro, Ronald Dahl, Charlotte Gotthard Mortz and Carsten Bindslev-Jensen

Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE⁺ B cells

Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE pla...

Authors: Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun and Kunmei Ji

Severity of allergic rhinitis impacts sleep and anxiety: results from a large Spanish cohort

Allergic rhinitis (AR) is a highly prevalent disease that generates high social and health care costs and also has a significant effect on quality of life and quality of sleep. It has also been related to some...

Authors: R. Muñoz-Cano, P. Ribó, G. Araujo, E. Giralt, J. Sanchez-Lopez and A. Valero

Early nonreactivity in the conjunctival provocation test predicts beneficial outcome of sublingual immunotherapy

Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctiva...

Authors: Janina Köther, Alicia Mandl, Silke Allekotte, Anatoli Astvatsatourov, Janin Chwieralski, Jan-Patrick Liedtke, Ursula Pieper-Fürst, Esther Raskopf, Kija Shah-Hosseini and Ralph Mösges

Sinus computed tomography predicts clinical response to corticosteroids in chronic rhinosinusitis with nasal polyps

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy...

Authors: Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang and Yueqi Sun

Rapid onset of action and reduced nasal hyperreactivity: new targets in allergic rhinitis management

This article summarizes a EUFOREA symposium, presented during the European Rhinology Research Forum in Brussels (9–10 November 2017; https://​www.​rhinologyresearc​h.​eu/​

Authors: C. Bachert, J. Bousquet and P. Hellings

5th Pediatric Allergy and Asthma Meeting (PAAM)

Authors:

Epidemiology of spider mite sensitivity: a meta-analysis and systematic review

Spider mites, including Tetranychus urticae, Panonychus citri, and Panonychus ulmi, are common pests in gardens, greenhouses, and orchards. Exposure, particularly occupational exposure, to these organisms may lea...

Authors: Ying Zhou, Haoyuan Jia, Xuming Zhou, Yubao Cui and Jun Qian

Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region

The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countrie...

Authors: Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská and Marek Malý

The impact of cold on the respiratory tract and its consequences to respiratory health

The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resultin...

Authors: Maria D’Amato, Antonio Molino, Giovanna Calabrese, Lorenzo Cecchi, Isabella Annesi-Maesano and Gennaro D’Amato

The feasibility of an allergy management support system (AMSS) for IgE-mediated allergy in primary care

The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. Th...

Authors: Bertine M. J. Flokstra-de Blok, Thecla M. Brakel, Marian Wubs, Ben Skidmore, Janwillem W. H. Kocks, Joanne N. G. Oude Elberink, Marie-Louise A. Schuttelaar, Jantina L. van der Velde, Thys van der Molen and Anthony E. J. Dubois

Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis

Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between...

Authors: Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A. Camargo Jr, Mübeccel Akdis, Cezmi A. Akdis…

An EAACI task force report: recognising the potential of the primary care physician in the diagnosis and management of drug hypersensitivity

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often se...

Authors: I. Doña, J. C. Caubet, K. Brockow, M. Doyle, E. Moreno, I. Terreehorst and M. J. Torres

Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012

Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five...

Authors: Rita Amaral, João A. Fonseca, Tiago Jacinto, Ana M. Pereira, Andrei Malinovschi, Christer Janson and Kjell Alving

7th International Symposium on Molecular Allergology (ISMA 2017)

Authors:

Consideration of methods for identifying mite allergens

House dust mites are small arthropods that produce proteins—found in their feces, body parts, and eggs—that are major triggers of human allergies worldwide. The goal of this review is to describe the current m...

Authors: Yubao Cui, Qiong Wang and Haoyuan Jia

Diverse expression of TNF-α and CCL27 in serum and blister of Stevens–Johnson syndrome/toxic epidermal necrolysis

The pathogenesis of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is not fully understood. Our previous study reported that chemokine CCL27 was overexpressed in serum of SJS/TEN patients. The...

Authors: Fang Wang, Yanting Ye, Ze-Yu Luo, Qian Gao, Di-Qing Luo and Xingqi Zhang

The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): verification of nasal allergen challenge procedures in a study utilizing an investigational immunotherapy for cat allergy

The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A...

Authors: Helen Neighbour, Mena Soliman, Lisa M. Steacy, Pascal Hickey, Beth Forbes, Mark Larché and Anne K. Ellis

Pollen and spore monitoring in the world

Ambient air quality monitoring is a governmental duty that is widely carried out in order to detect non-biological (“chemical”) components in ambient air, such as particles of < 10 µm (PM10, PM2.5), ozone, sulphu...

Authors: J. T. M. Buters, C. Antunes, A. Galveias, K. C. Bergmann, M. Thibaudon, C. Galán, C. Schmidt-Weber and J. Oteros

Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations

Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the ...

Authors: Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie and Stella Cochrane

Effectiveness of icatibant for treatment of hereditary angioedema attacks is not affected by body weight: findings from the Icatibant Outcome Survey, a cohort observational study

Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of b...

Authors: Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J. Longhurst, Laurence Bouillet and Irmgard Andresen

The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps

Chronic rhinosinusitis (CRS), commonly divided into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) is an inflammatory disease which mechanism remain unclear. Leucine-rich repeat kinase 2 (LRR...

Authors: Yue Ma, Chunquan Zheng and Le Shi

On-demand intermittent beclomethasone is effective for mild asthma in Brazil

Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persisten...

Authors: Paulo Camargos, Alessandra Affonso, Geralda Calazans, Lidiana Ramalho, Marisa L. Ribeiro, Nulma Jentzsch, Simone Senna and Renato T. Stein

Publication trends of Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy journals: a MeSH term-based bibliometric analysis

We performed a MeSH term-based bibliometric analysis aiming to assess the publication trends of EAACI journals, namely Allergy, Pediatric Allergy and Immunology (PAI) (from 1990 to 2015) and Clinical and Trans...

Authors: Daniel Martinho-Dias, Bernardo Sousa-Pinto, Júlio Botelho-Souza, António Soares, Luís Delgado and João Almeida Fonseca

Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma

Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways....

Authors: Wei Tang, Steven G. Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M. Salter, Gail M. Gauvreau, Paul M. O’Byrne and Roma Sehmi

Development and validation of a standardized double-blind, placebo-controlled food challenge matrix for raw hazelnuts

Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various pra...

Authors: Marjolein Vandekerckhove, Bart Van Droogenbroeck, Marc De Loose, Katleen Coudijzer, Marc Coppens, Philippe Gevaert and Hilde Lapeere

Correction to: Better recognition, diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy: iMAP—an international interpretation of the MAP (Milk Allergy in Primary Care) guideline

In the original version of this article [1], published on 23 August 2017, an incorrect version of Additional file 4 has been used. The corrected version of Additional file 4 is given in this correction.

Authors: Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M. Fleischer, Ralf G. Heine, Michael Levin, Mario C. Vieira and Adam T. Fox

Stevens–Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database

Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents...

Authors: Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Osvaldo Correia and Luís Delgado

MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles

European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to dete...

Authors: Maja A. Hofmann, Ana Giménez-Arnau, Werner Aberer, Carsten Bindslev-Jensen and Torsten Zuberbier

European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases: report of the European Union Parliament Summit (29 March 2017)

On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. ...

Authors: Peter W. Hellings, David Borrelli, Sirpa Pietikainen, Ioana Agache, Cezmi Akdis, Claus Bachert, Michael Bewick, Erna Botjes, Jannis Constantinidis, Wytske Fokkens, Tari Haahtela, Claire Hopkins, Maddalena Illario, Guy Joos, Valerie Lund, Antonella Muraro…

EAACI/ESCD Skin Allergy Meeting 2017 (SAM 2017)

Authors:

Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil

In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) ...

Authors: Mônica Versiani Nunes Pinheiro de Queiroz, Cristina Gonçalves Alvim, Álvaro A. Cruz and Laura Maria de Lima Belizário Facury Lasmar

How to manage anaphylaxis in primary care

Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different com...

Authors: Alberto Alvarez-Perea, Luciana Kase Tanno and María L. Baeza

Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis

Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and...

Authors: M. Fröhlich, M. Pinart, T. Keller, A. Reich, B. Cabieses, C. Hohmann, D. S. Postma, J. Bousquet, J. M. Antó, T. Keil and S. Roll

Prediction and prevention of allergy and asthma in EAACI journals (2016)

The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

Authors: Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W. Hellings and Ioana Agache

Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial

Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was t...

Authors: Andrzej Bożek, Krzysztof Kołodziejczyk, Renata Kozłowska and Giorgio Walter Canonica

Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis

Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an im...

Authors: Yumei Liu, Jianglong Peng, Ying Zhou and Yubao Cui

Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy

The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storag...

Authors: Mark A. Blankestijn, André C. Knulst, Edward F. Knol, Thuy-My Le, Heike Rockmann, Henny G. Otten and Rob J. B. Klemans

Is a positive intracutaneous test induced by penicillin mediated by histamine? A cutaneous microdialysis study in penicillin-allergic patients

Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may...

Authors: Line K. Tannert, Sidsel Falkencrone, Charlotte G. Mortz, Carsten Bindslev-Jensen and Per Stahl Skov

Differences in medication adherence are associated with beliefs about medicines in asthma and COPD

Adherence to medication is crucial for achieving treatment control in chronic obstructive lung diseases. This study refers to the “necessity-concerns framework” and examines the associations between beliefs a...

Authors: Susanne Brandstetter, Tamara Finger, Wiebke Fischer, Magdalena Brandl, Merle Böhmer, Michael Pfeifer and Christian Apfelbacher

Local allergic rhinitis: evolution of concepts

The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local aller...

Authors: Cristoforo Incorvaia, Nicola Fuiano, Irene Martignago, Bruna L. Gritti and Erminia Ridolo

CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report

A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, i...

Authors: J. Bousquet, G. L. Onorato, C. Bachert, M. Barbolini, A. Bedbrook, L. Bjermer, J. Correia de Sousa, N. H. Chavannes, A. A. Cruz, E. De Manuel Keenoy, P. Devillier, J. Fonseca, S. Hun, T. Kostka, P. W. Hellings, M. Illario…