Articles

Milk- and wheat protein drinks for double blind placebo controlled food challenge in adults: a simple tool for diagnosis

Authors: J. van Odijk and H. M. Lindqvist

Contraindications to immunotherapy: a global approach

Recommendations on contraindications to allergen immunotherapy (AIT) have been independently developed by National and International Societies/Academies. AIT contraindications are mainly based on case reports,...

Authors: C. Pitsios, M. Tsoumani, M. B. Bilò, G. J. Sturm, P. Rodríguez del Río, R. Gawlik, F. Ruëff, G. Paraskevopoulos, E. Valovirta, O. Pfaar, M. A. Calderón and P. Demoly

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support th...

Authors: J. Jean Bousquet, Holger J. Schünemann, Alkis Togias, Marina Erhola, Peter W. Hellings, Torsten Zuberbier, Ioana Agache, Ignacio J. Ansotegui, Josep M. Anto, Claus Bachert, Sven Becker, Martin Bedolla-Barajas, Michael Bewick, Sinthia Bosnic-Anticevich, Isabelle Bosse, Louis P. Boulet…

The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA²LEN study

Asthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA²LEN) que...

Authors: Afshin Ostovar, Wytske J. Fokkens, Safoora Pordel, Ali Movahed, Khadijeh Ghasemi, Maryam Marzban and Shokrollah Farrokhi

Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis

Dermatological illness can affect the quality of life and may coexist with psychiatric disorders.

Authors: Gerasimos N. Konstantinou and George N. Konstantinou

Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations

Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship...

Authors: David B. Price, Sinthia Bosnic-Anticevich, Ian D. Pavord, Nicolas Roche, David M. G. Halpin, Leif Bjermer, Omar S. Usmani, Guy Brusselle, Simon Wan Yau Ming and Sarang Rastogi

An update to the Milk Allergy in Primary Care guideline

The Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps be...

Authors: Adam Fox, Trevor Brown, Joanne Walsh, Carina Venter, Rosan Meyer, Anna Nowak-Wegrzyn, Michael Levin, Hannah Spawls, Jolene Beatson, Marie-Therese Lovis, Mario C. Vieira and David Fleischer

Gene expression of TMEM178, which encodes a negative regulator of NFATc1, decreases with the progression of asthma severity

In two independent microarray studies involving primary airway epithelial cells, the relative gene expression of TMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for fu...

Authors: Naiya B. Patel, Lorena A. Ostilla, Lyda Cuervo-Pardo, Sergejs Berdnikovs and Sergio E. Chiarella

Characteristics, quality of life and control of respiratory allergic diseases caused by house dust mites (HDMs) in Spain: a cross-sectional study

This multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14–55 years and had allergic rhinitis and/or asthma, which was due...

Authors: Beristain Ana and Fernando de la Torre

Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and co...

Authors: Polliana Mihaela Leru

Elderly versus younger patients with hereditary angioedema type I/II: patient characteristics and safety analysis from the Icatibant Outcome Survey

Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling in subcutaneous or submucosal tissues. Symptoms often begin by age 5–11 years and worsen during puberty, b...

Authors: Anette Bygum, Teresa Caballero, Anete S. Grumach, Hilary J. Longhurst, Laurence Bouillet, Werner Aberer, Andrea Zanichelli, Jaco Botha, Irmgard Andresen and Marcus Maurer

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of ...

Authors: Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park and Young-Min Ye

High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients...

Authors: Zonne L. M. Hofman, Nikki van West, C. Erik Hack, André C. Knulst, Coen Maas and Heike Röckmann

Molecular clustering of genes related to the atopic syndrome: Towards a more tailored approach and personalized medicine?

The atopic syndrome consists of heterogeneous manifestations, in which multiple associated genetic loci have recently been identified. It is hypothesized that immune dysregulation plays a role in the pathogene...

Authors: Jill de Wit, Rogier T. A. van Wijck, Virgil A. S. H. Dalm, Kristen L. Snyder, Joan E. E. Totté, Suzanne G. M. A. Pasmans and Peter J. van der Spek

Comparison of two multiplex arrays in the diagnostics of allergy

The objective of this analysis was to compare the multiplex ImmunoCAP ISAC (Thermo Fisher Scientific, Sweden) and the multiplex Alex Allergy Explorer (Macro Array Diagnostics GmbH, Austria) platform on specifi...

Authors: Jana Bojcukova, Tomas Vlas, Peter Forstenlechner and Petr Panzner

Sesame oleosins are minor allergens

In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are ...

Authors: Anna M. Ehlers, Madlen Rossnagel, Bettina Brix, Mark A. Blankestijn, Thuy-My Le, Waltraud Suer, Henny G. Otten and André C. Knulst

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical tre...

Authors: Lien Calus, Nicholas Van Bruaene, Cedric Bosteels, Sarah Dejonckheere, Thibaut Van Zele, Gabrielle Holtappels, Claus Bachert and Philippe Gevaert

Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis

Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates th...

Authors: Ralph Mösges, Antonio Valero Santiago, Silke Allekotte, Nilufar Jahed, Anatoli Astvatsatourov, Angelika Sager and Jaime Sánchez-López

A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial

Altered gut microbiota is implicated in cow’s milk allergy (CMA) and differs markedly from healthy, breastfed infants. Infants who suffer from severe CMA often rely on cow’s milk protein avoidance and, when br...

Authors: Harm Wopereis, Marleen T. J. van Ampting, Aysun Cetinyurek-Yavuz, Rob Slump, David C. A. Candy, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, Adam T. Fox, Neil Shah, Guus Roeselers, Lucien F. Harthoorn, Louise J. Michaelis, Jan Knol and Christina E. West

Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus

The identification of house dust mite (HDM) allergens and epitopes is important for allergy diagnosis and treatment. We sought to identify the Dermatophagoides pteronyssinus group 24 allergen (Der p 24) and to id...

Authors: Ze-Lang Cai, Jia-Jie Chen, Zhen Zhang, Yi-Bo Hou, Yong-shen He, Jin-Lyu Sun and Kunmei Ji

Clinical and serological follow-up of patients with WDEIA

The clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recomm...

Authors: Morten J. Christensen, Esben Eller, Charlotte G. Mortz, Knut Brockow and Carsten Bindslev-Jensen

Psychosocial working conditions, asthma self-management at work and asthma morbidity: a cross-sectional study

Adverse psychosocial working conditions—in particular poor job decision latitude and poor social support at work—may impair the effective implementation of asthma self-management behaviour at work and may be a...

Authors: Katherina Heinrichs, Stefan Hummel, Jalal Gholami, Konrad Schultz, Jian Li, Aziz Sheikh and Adrian Loerbroks

Skin microdialysis: methods, applications and future opportunities—an EAACI position paper

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive...

Authors: Katrine Y. Baumann, Martin K. Church, Geraldine F. Clough, Sven Roy Quist, Martin Schmelz, Per Stahl Skov, Chris D. Anderson, Line Kring Tannert, Ana Maria Giménez-Arnau, Stefan Frischbutter, Jörg Scheffel and Marcus Maurer

Correction to: Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort

Following publication of the original article [1], the authors reported that one of the authors’ name was spelled incorrectly.

Authors: Filip Raciborski, Jean Bousquet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z. Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska…

Prevalence of food hypersensitivity in relation to IgE sensitisation to common food allergens among the general adult population in West Sweden

The prevalence of self-experienced adverse reactions to foods seems to have an increasing trend in both adults and children. However, it is unclear if the prevalence of food hypersensitivity in the Swedish adu...

Authors: G. Rentzos, L. Johanson, Emma Goksör, E. Telemo, Bo Lundbäck and L. Ekerljung

The REal Life EVidence AssessmeNt Tool (RELEVANT): development of a novel quality assurance asset to rate observational comparative effectiveness research studies

Evidence from observational comparative effectiveness research (CER) is ranked below that from randomized controlled trials in traditional evidence hierarchies. However, asthma observational CER studies repre...

Authors: Jonathan D. Campbell, Robert Perry, Nikolaos G. Papadopoulos, Jerry Krishnan, Guy Brusselle, Alison Chisholm, Leif Bjermer, Michael Thomas, Eric van Ganse, Maarten van den Berge, Jennifer Quint, David Price and Nicolas Roche

Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group—European Academy of Allergy and Clinical Immunology Task Force

A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observa...

Authors: Nicolas Roche, Jonathan D. Campbell, Jerry A. Krishnan, Guy Brusselle, Alison Chisholm, Leif Bjermer, Mike Thomas, Eric van Ganse, Maarten van den Berge, George Christoff, Jennifer Quint, Nikolaos G. Papadopoulos and David Price

Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers

In wheat-dependent exercise-induced anaphylaxis (WDEIA), cofactors such as exercise, acetylsalicylic acid (ASA), alcohol or unfavorable climatic conditions are required to elicit a reaction to wheat products. ...

Authors: Katharina Anne Scherf, Ann-Christin Lindenau, Luzia Valentini, Maria Carmen Collado, Izaskun García-Mantrana, Morten Christensen, Dirk Tomsitz, Claudia Kugler, Tilo Biedermann and Knut Brockow

Adverse drug reaction classification by health professionals: appropriate discrimination between allergy and intolerance?

The correct classification of an adverse drug reaction (ADR) as allergy (immunological) or intolerance (non-immunological) has important clinical implications. The aim of this study was to examine the ability ...

Authors: Sepehr Shakib, Gillian E. Caughey, Jie Shen Fok and William B. Smith

Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007–2012: the importance of comprehensive data availability

Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approa...

Authors: Rita Amaral, Ana M. Pereira, Tiago Jacinto, Andrei Malinovschi, Christer Janson, Kjell Alving and João A. Fonseca

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multi...

Authors: J. Bousquet, A. Bedbrook, W. Czarlewski, G. L. Onorato, S. Arnavielhe, D. Laune, E. Mathieu-Dupas, J. Fonseca, E. Costa, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, M. Illario, E. Menditto, G. W. Canonica, L. Cecchi…

Cosmetics for neonates and infants: haptens in products’ composition

Cosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since all...

Authors: Karolina Dumycz, Katarzyna Kunkiel and Wojciech Feleszko

Two grass pollen tablets commercially available for allergy immunotherapy display different IgE epitope repertoires

The distribution of Pooideae species varies across Europe. Especially, Timothy is less represented in Southern than in Northern Europe. Since allergenic cross-reactivity between pollens from different grasses ...

Authors: Thierry Batard, Amparo Sanjuan, Laure Denis, Hélène Nguyen, Armelle Montagut, Joaquín Sastre, Sabina Rak and Jean F. Cuiné

Evaluation of major mite allergens from European standardized commercial extracts for in vivo diagnosis: addressing the need for precision medicine

Skin prick testing is the first-line interventional method to diagnose IgE mediated allergic diseases. Methodological differences in manufacturing processes and extract standardization may lead to variations i...

Authors: Ruperto González-Pérez, Paloma Poza-Guedes, Yvelise Barrios del Pino, Víctor Matheu and Inmaculada Sánchez-Machín

Characterization of a subgroup of non-type 2 asthma with cow’s milk hypersensitivity in young subjects

Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perce...

Authors: N. Tsolakis, L. Nordvall, C. Janson, N. Rydell, A. Malinovschi and K. Alving

Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens

Japanese cedar (JC) pollinosis is a serious type I allergic disease in Japan. Although subcutaneous immunotherapy and sublingual immunotherapy have been applied to treat JC pollinosis, high doses of allergens ...

Authors: Shinya Takaishi, Saburo Saito, Minori Kamada, Nobuyoshi Otori, Hiromi Kojima, Kenjiro Ozawa and Fumio Takaiwa

Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies

Skin prick tests (SPTs) are essential for the diagnosis of IgE-mediated allergy and are influenced by extract quality, biological potency and concentration of allergen.

Authors: Nicola Wagner and Michael Rudert

Identification of the recently described plasminogen gene mutation p.Lys330Glu in a family from Northern Germany with hereditary angioedema

Hereditary angioedema (HAE) is a life-threatening disease characterized by recurrent episodes of subcutaneous and mucosal swellings and abdominal cramping. Corticosteroids and antihistamines, which are usually...

Authors: Andreas Recke, Elisabeth G. Massalme, Uta Jappe, Lars Steinmüller-Magin, Julia Schmidt, Yorck Hellenbroich, Irina Hüning, Gabriele Gillessen-Kaesbach, Detlef Zillikens and Karin Hartmann

Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort

Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic mu...

Authors: Filip Raciborski, Jean Bousqet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z. Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska…

Health-related quality of life worsens by school age amongst children with food allergy

Food allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such...

Authors: Victoria Thörnqvist, Roelinde Middelveld, Hay Mar Wai, Natalia Ballardini, Evalill Nilsson, Jennie Strömquist, Staffan Ahlstedt, Lennart Jan Nilsson and Jennifer L. P. Protudjer

Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement

Allergic rhinitis (AR) affects 23–30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontr...

Authors: P. W. Hellings, B. Pugin, G. Mariën, C. Bachert, C. Breynaert, D. M. Bullens, J. L. Ceuppens, G. Clement, T. Cox, D. Ebo, P. Gevaert, S. Halewyck, V. Hox, K. Ladha, R. Jacobs, P. Rombaux…

The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients

Atopic dermatitis (AD) is a complex heterogeneous chronic inflammatory skin disease. Specific IgE antibodies against autoantigens have been observed in a subgroup of AD patients, however, little is known about...

Authors: Maria Mikus, Catharina Johansson, Nathalie Acevedo, Peter Nilsson and Annika Scheynius

Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases

Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patie...

Authors: A. Valiulis, J. Bousquet, A. Veryga, U. Suprun, D. Sergeenko, S. Cebotari, D. Borelli, S. Pietikainen, J. Banys, I. Agache, N. E. Billo, A. Bush, I. Chkhaidze, L. Dubey, W. J. Fokkens, J. Grigg…

The roadmap for the Allergology specialty and allergy care in Europe and adjacent countries. An EAACI position paper

The high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well-trained specialists. However, the ...

Authors: N. Fyhrquist, T. Werfel, M. B. Bilò, N. Mülleneisen and R. Gerth van Wijk

A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial

Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infant...

Authors: Adam T. Fox, Harm Wopereis, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, David C. A. Candy, Neil Shah, Christina E. West, Johan Garssen, Lucien F. Harthoorn, Jan Knol and Louise J. Michaelis

Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review

There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influence...

Authors: Ozlem Keskin, Niloufar Farzan, Esra Birben, Hayriye Akel, Cagatay Karaaslan, Anke H. Maitland-van der Zee, Michael E. Wechsler, Susanne J. Vijverberg and Omer Kalayci

Dual exposure to smoking and household air pollution is associated with an increased risk of severe asthma in adults in Brazil

The relationship between smoking, household pollution, dual exposure and severity of asthma in adults has not been sufficiently studied. We examined and compared the effects of cigarette smoking, domestic wood...

Authors: Andréia Guedes Oliva Fernandes, Carolina de Souza-Machado, Gabriela Pimentel Pinheiro, Sergio Telles de Oliva, Raquel Cristina Lins Mota, Valmar Bião de Lima, Constança Sampaio Cruz, José Miguel Chatkin and Álvaro A. Cruz

Relationship between vitamin D and chronic spontaneous urticaria: a systematic review

Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study...

Authors: Papapit Tuchinda, Kanokvalai Kulthanan, Leena Chularojanamontri, Sittiroj Arunkajohnsak and Sutin Sriussadaporn

Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps

Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure...

Authors: Rui Zheng, Dan Wang, Kai Wang, Wen-Xiang Gao, Qin-Tai Yang, Li-Jie Jiang, Min Zhou, Yu-Jie Cao, Jianbo Shi and Yueqi Sun

Highlights and recent developments in airway diseases in EAACI journals (2017)

The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

Authors: J. Bousquet, C. A. Akdis, C. Grattan, P. A. Eigenmann, K. Hoffmann-Sommergruber, P. W. Hellings and I. Agache