Articles

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) a...

Authors: Fariza Mishaal Saiema Badloe, Shauni De Vriese, Katarina Coolens, Carsten B. Schmidt-Weber, Johannes Ring, Jan Gutermuth and Inge Kortekaas Krohn

Allergen exposure chambers: implementation in clinical trials in allergen immunotherapy

Allergen exposure chambers (AECs) have been developed for controlled allergen challenges of allergic patients mimicking natural exposure. As such, these facilities have been utilized e.g., for proof of concept...

Authors: O. Pfaar and P. Zieglmayer

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-...

Authors: D. Ferastraoaru, H. J. Bax, C. Bergmann, M. Capron, M. Castells, D. Dombrowicz, E. Fiebiger, H. J. Gould, K. Hartmann, U. Jappe, G. Jordakieva, D. H. Josephs, F. Levi-Schaffer, V. Mahler, A. Poli, D. Rosenstreich…

Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis

One of the important pathogeneses of eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence of allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on th...

Authors: Yun Ma, Maojin Liang, Peng Tian, Xiang Liu, Hua Dang, Qiujian Chen, Hua Zou and Yiqing Zheng

Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients

Emerging data indicates that extracellular traps (ETs), structures formed by various immune cell types, may contribute to the pathology of noninfectious inflammatory diseases. Histone hypercitrullination is an...

Authors: Pawel Kuczia, Joanna Zuk, Teresa Iwaniec, Jerzy Soja, Jerzy Dropinski, Marta Malesa-Wlodzik, Lech Zareba, Jan G. Bazan, Anetta Undas and Stanislawa Bazan-Socha

Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper

Farmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respirator...

Authors: T. Sigsgaard, I. Basinas, G. Doekes, F. de Blay, I. Folletti, D. Heederik, A. Lipinska-Ojrzanowska, D. Nowak, M. Olivieri, S. Quirce, M. Raulf, J. Sastre, V. Schlünssen, J. Walusiak-Skorupa and A. Siracusa

Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid as...

Authors: Ming Wang, Xiangting Bu, Ge Luan, Liqing Lin, Yang Wang, Jianmin Jin, Luo Zhang and Chengshuo Wang

The disease burden in patients with respiratory allergies induced by house dust mites: a year-long observational survey in three European countries

House dust mite (HDM) allergens constitute the most frequent cause of persistent allergic rhinitis and asthma. The symptoms vary throughout the year but typically peak in spring, autumn and (to a lesser extent...

Authors: Pascal Demoly, Andrea Matucci, Oliviero Rossi and Carmen Vidal

Allergen Immunotherapy (AIT) in children: a vulnerable population with its own rights and legislation – summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019

Concerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use...

Authors: V. Mahler, D. Mentzer, A. Bonertz, A. Muraro, P. Eigenmann, J. Bousquet, S. Halken, O. Pfaar, M. Jutel, U. Wahn, S. Vieths and S. Kaul

Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis

A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis with nasal polyps (CRSwNP), the presence of which may adversely...

Authors: Enrico Heffler, Fabiana Saccheri, Marta Bartezaghi and Giorgio Walter Canonica

Digital transformation of health and care to sustain Planetary Health: The MASK proof-of-concept for airway diseases—POLLAR symposium under the auspices of Finland’s Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing

In December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the F...

Authors: Jean Bousquet, Josep M. Anto, Tari Haahtela, Pekka Jousilahti, Marina Erhola, Xavier Basagaña, Wienczyslawa Czarlewski, Mikaëla Odemyr, Susanna Palkonen, Mikael Sofiev, César Velasco, Anna Bedbrook, Rodrigo Delgado, Rostislav Kouznetsov, Mika Mäkelä, Yuliia Palamarchuk…

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model

Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti

Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome

Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic protei...

Authors: Claudia Alessandri, Rosetta Ferrara, Maria Livia Bernardi, Danila Zennaro, Lisa Tuppo, Ivana Giangrieco, Teresa Ricciardi, Maurizio Tamburrini, Maria Antonietta Ciardiello and Adriano Mari

Epinephrine delivery via EpiPen^® Auto-Injector or manual syringe across participants with a wide range of skin-to-muscle distances

Intramuscular (IM) injection of epinephrine (adrenaline) at the mid-anterolateral (AL) thigh is the international standard therapy for acute anaphylaxis. Concerns exist regarding implications of epinephrine au...

Authors: Margitta Worm, DucTung Nguyen, Russ Rackley, Antonella Muraro, George Du Toit, Tracey Lawrence, Hong Li, Kurt Brumbaugh and Magnus Wickman

Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome

Authors: Alejandra González Pérez, Antonio Carbonell Martínez, Ana Isabel Escudero Pastor, Cristina Navarro Garrido and Juan Carlos Miralles López

New approach to intermittent and mild asthma therapy: evolution or revolution in the GINA guidelines?

New recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. These recommendations provide very important changes to the management of asthma, especi...

Authors: Izabela Kuprys-Lipinska, Marta Kolacinska-Flont and Piotr Kuna

Viral infections and wheezing–asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?

Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later lif...

Authors: Giovanni A. Rossi, Petr Pohunek, Wojciech Feleszko, Stefania Ballarini and Andrew A. Colin

Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients

Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. Malassezia globosa, a skin resident fungus...

Authors: Sabine Altrichter, Pia Schumacher, Ola Alraboni, Yiyu Wang, Makiko Hiragun, Michihiro Hide and Marcus Maurer

Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most curren...

Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort

Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited.

Authors: Erik Melén, Anna Bergström, Inger Kull, Catarina Almqvist, Niklas Andersson, Anna Asarnoj, Magnus P. Borres, Antonis Georgellis, Göran Pershagen, Marit Westman, Marianne van Hage and Natalia Ballardini

EAACI anaphylaxis guidelines: systematic review protocol

Authors: Debra de Silva, Graham Roberts, Margitta Worm and Antonella Muraro

COST Action ‘ImpARAS’: what have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium

The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources ...

Authors: Kitty Verhoeckx, Katrine Lindholm Bøgh, Anne Constable, Michelle M. Epstein, Karin Hoffmann Sommergruber, Thomas Holzhauser, Geert Houben, Annette Kuehn, Erwin Roggen, Liam O’Mahony, Ben Remington and René Crevel

EAACI Task force Clinical epidemiology of anaphylaxis: experts’ perspective on the use of adrenaline autoinjectors in Europe

Worldwide, guidelines recommend the use of adrenaline autoinjectors (AAIs) for self-medication in patients who experience severe allergic reaction. The European Medical Agency recommends the prescription of tw...

Authors: Magdalena Kraft, Sabine Dölle-Bierke, Paul J. Turner, Antonella Muraro, Montserrat Fernández-Rivas, Linus Grabenhenrich and Margitta Worm

Clinical trials in allergen immunotherapy in the age group of children and adolescents: current concepts and future needs

Allergen immunotherapy (AIT) is the only treatment option available for allergic patients with disease-modifying intention. Both efficacy and safety has been demonstrated for multiple trials in children, adole...

Authors: O. Pfaar, R. Gerth van Wijk, L. Klimek, J. Bousquet and P. S. Creticos

Impact on quality of life and safety of sublingual and subcutaneous immunotherapy in children with severe house dust mite and pollen-associated allergic rhinoconjunctivitis

Pollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previou...

Authors: Thomas Proctor, Elodie Morrough, Otto Fenske, Sarah Allatt, Stephen M. Hughes, Vibha Sharma and Peter D. Arkwright

Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes

Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.

Authors: Dimitrios I. Mitsias, Maria V. Dimou, John Lakoumentas, Konstantinos Alevizopoulos, Bernardo Sousa-Pinto, Joao A. Fonseca, Jean Bousquet and Nikolaos G. Papadopoulos

Development of a model care pathway for the management of Hymenoptera venom allergy: evidence-based key interventions and indicators

Hymenoptera venom allergy (HVA) is an underestimated condition representing an important cause of morbidity and mortality worldwide. Preventing future allergic reactions in patients who have already developed ...

Authors: Maria Beatrice Bilò, Alice Corsi, Valerio Pravettoni, Donatella Bignardi, Patrizia Bonadonna, Oliviero Quercia, Marina Mauro, Elio Novembre, Rebecca Micheletti and Roberto Papa

Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen component analysis

Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only r...

Authors: Viiu Blöndal, Fredrik Sundbom, Magnus P. Borres, Marieann Högman, Kjell Alving, Andrei Malinovschi and Christer Janson

Eczema phenotypes and risk of allergic and respiratory conditions in school age children

Eczema phenotypes based on eczema onset and persistence might better identify groups prone to allergic and respiratory conditions than a binary definition of eczema. We examined the associations of childhood e...

Authors: Chen Hu, Tamar Nijsten, Evelien R. van Meel, Nicole S. Erler, Christophe Piketty, Nicolette W. de Jong, Suzanne G. M. A. Pasmans, Johan C. de Jongste and Liesbeth Duijts

Modified protocol of omalizumab treatment to prevent carboplatin-induced drug hypersensitivity reactions: a case study

Carboplatin administration can usually be safely continued via a so-called desensitisation protocol when hypersensitivity reactions arise. Severe break-through reactions that occur early during desensitisation...

Authors: Hanneke N. G. Oude Elberink, Mathilde Jalving, Hilda Dijkstra and Annick A. J. M. van de Ven

Healthy people in healthy premises: the Finnish Indoor Air and Health Programme 2018–2028

Clean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase th...

Authors: Jussi Lampi, Anne Hyvärinen, Marina Erhola, Tari Haahtela, Kyösti Haukipuro, Ulla Haverinen-Shaughnessy, Kaisa Jalkanen, Kirsi Karvala, Sanna Lappalainen, Kari Reijula, Hannele Rämö, Markku Sainio, Anniina Salmela, Mika Salminen, Tuula Vasankari and Juha Pekkanen

Indoor mold odor in the workplace increases the risk of Asthma-COPD Overlap Syndrome: a population-based incident case–control study

Previous studies have suggested an increased risk of asthma related to indoor dampness problems, but their role in the etiology of Asthma-COPD Overlap Syndrome has not been studied. We utilized a population-ba...

Authors: Maritta S. Jaakkola, Taina K. Lajunen and Jouni J. K. Jaakkola

A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement

Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in deta...

Authors: Frank E. van Boven, Nicolette W. de Jong, Gert-Jan Braunstahl, Roy Gerth van Wijk and Lidia R. Arends

Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been ...

Authors: Valerie Hox, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol…

House dust mite sensitisation and association with atopic dermatitis in Brunei

IgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (D...

Authors: Haziq Emran, Christina Siew Eng Chieng, Surita Taib and Anne Catherine Cunningham

Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients

Data regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52 weeks were followed...

Authors: Yanran Huang, Chengshuo Wang, Xi Lin, Hongfei Lou, Feifei Cao, Wenhan Li, Yuan Zhang and Luo Zhang

Rhinovirus species and tonsillar immune responses

Rhinovirus A and C infections are important contributors to asthma induction and exacerbations. No data exist on the interaction of local immune responses in rhinovirus infection. Therefore, we aimed to determ...

Authors: Emilia Mikola, Oscar Palomares, Riitta Turunen, Matti Waris, Lotta E. Ivaska, Antti Silvoniemi, Tuomo Puhakka, Beate Rückert, Tytti Vuorinen, Mübeccel Akdis, Cezmi A. Akdis and Tuomas Jartti

Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration

The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress inflammatory responses in different cells. In this study,...

Authors: Anet Kivihall, Alar Aab, Jerzy Soja, Krzysztof Sładek, Marek Sanak, Alan Altraja, Bogdan Jakiela, Grazyna Bochenek and Ana Rebane

Association of IKZF1 SNPs in cold medicine-related Stevens–Johnson syndrome in Thailand

Our meta-analysis of several ethnic groups (Japanese, Korean, Indian, Brazilian) revealed a significant genome-wide association between cold medicine-related SJS/TEN (CM-SJS/TEN) with severe ocular complicatio...

Authors: Patchima Chantaren, Passara Jongkhajornpong, Mayumi Ueta, Vilavun Puangsricharern, Kaevalin Lekhanont, Phattrawan Pisuchpen, Pinnita Prabhasawat, Kanya Suphapeetiporn and Shigeru Kinoshita

Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)

The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI inclu...

Authors: C. A. Akdis, J. Bousquet, C. E. Grattan, P. A. Eigenmann, K. Hoffmann-Sommergruber, I. Agache and M. Jutel

Adherence to adrenaline autoinjector prescriptions in patients with anaphylaxis

This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe ...

Authors: Louise Parke, Annemarie Schaeffer Senders, Carsten Bindslev-Jensen, Annmarie Touborg Lassen, Athamaica Ruiz Oropeza, Susanne Halken, Sigurd Broesby-Olsen, Henrik Fomsgaard Kjær and Charlotte G. Mortz

Eliciting dose is associated with tolerance development in peanut and cow’s milk allergic children

Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the...

Authors: C. Nitsche, C. D. Westerlaken-van Ginkel, B. J. Kollen, A. B. Sprikkelman, G. H. Koppelman and A. E. J. Dubois

Helsinki by nature: The Nature Step to Respiratory Health

The Nature Step to Respiratory Health was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed t...

Authors: Tari Haahtela, Leena von Hertzen, Josep M. Anto, Chunxue Bai, Abay Baigenzhin, Eric D. Bateman, Digambar Behera, Kazi Bennoor, Paulo Camargos, Niels Chavannes, Jaime Correia de Sousa, Alvaro Cruz, Maria Do Céu Teixeira, Marina Erhola, Eeva Furman, Bilun Gemicioğlu…

Short-acting β2-agonists (SABA) bronchodilator sales and outdoor mould in central France

Temporal ecological studies have shown that outdoor moulds are associated with severe asthma exacerbations, as emergency department visits or hospitalisations. The aim of this was to assess the associations be...

Authors: D. M. Caillaud, S. Martin, C. Ségala, N. Dupuy, M. Thibaudon and D. Muti

The safety and tolerability profile of bilastine for chronic urticaria in children

Urticaria is a condition defined by the development of wheals, angioedema or both. It is classified based on its duration as acute (≤ 6 weeks) or chronic (> 6 weeks). Chronic urticaria is less frequent than ac...

Authors: Nikolaos G. Papadopoulos and Torsten Zuberbier

Risk factors for severe systemic sting reactions in wasp (Vespula spp.) and honeybee (Apis mellifera) venom allergic patients

Hymenoptera stings are a major cause of anaphylaxis. Various risk factors are discussed in literature. This study aims to investigate potential risk factors for severe sting reactions in wasp (Vespula spp.) and h...

Authors: Danielle Fehr, Sara Micaletto, Thomas Moehr and Peter Schmid-Grendelmeier

Correction to: ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Following publication of the original article [1], the authors reported that one of the authors’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author...

Authors: J. Bousquet and M. van Hage

Correction to: Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

Following publication of the original article [1], the authors reported that one of the collaborators’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the ...

Authors: J. Bousquet

Correction to: MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence

Following publication of the original article [1], the authors reported that one of the collaborators’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the ...

Authors: J. Bousquet

Clinically relevant effect of rupatadine 20 mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis

Different clinical trials showed the superior efficacy of rupatadine compared to placebo at improving seasonal allergic rhinitis (SAR) symptoms, but no study has assessed if the response promoted is clinically...

Authors: Joaquim Mullol, Iñaki Izquierdo, Kimihiro Okubo, Giorgio Walter Canonica, Jean Bousquet and Antonio Valero