Articles

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

The role of chemokines in anaphylaxis is unclear.

Authors: Romana Vantur, Marusa Rihar, Ana Koren, Matija Rijavec, Peter Kopac, Urska Bidovec-Stojkovic, Renato Erzen and Peter Korosec

Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium

Asthma is a chronic respiratory disease which is not curable, yet some patients experience spontaneous remission. We hypothesized that epigenetic mechanisms may be involved in asthma remission.

Authors: Cancan Qi, Judith M. Vonk, Diana A. van der Plaat, Maartje A. E. Nieuwenhuis, F. Nicole Dijk, Dylan Aïssi, Valérie Siroux, H. Marike Boezen, Cheng-jian Xu and Gerard H. Koppelman

Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study

The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was...

Authors: A. Bédard, X. Basagaña, J. M. Anto, J. Garcia-Aymerich, P. Devillier, S. Arnavielhe, A. Bedbrook, G. L. Onorato, W. Czarlewski, R. Murray, R. Almeida, J. A. Fonseca, J. Correia da Sousa, E. Costa, M. Morais-Almeida, A. Todo-Bom…

A novel ELISA method to determine human MrgX2 in chronic urticaria

Mas-related G-protein coupled receptor member X2 (MrgX2) directly mediates drug-induced pseudo allergic reactions. Skin mast cell MrgX2 is upregulated in severe chronic urticaria (CU). Mast cells and leukocyte...

Authors: Yuanyuan Ding, Tao Zhang, Rui Liu, Delu Che, Nan Wang and Langchong He

A pragmatic randomized controlled trial to improve inhaler technique using mHealth

Authors: Anna Vanoverschelde, Paulien van der Wel, Barbara Putman and Lies Lahousse

Penicillin and cephalosporin cross-reactivity: role of side chain and synthetic cefadroxil epitopes

Analysis of cross-reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam most often involved in immediate hypersensitivity reactions (I...

Authors: Gador Bogas, Cristobalina Mayorga, Ángela Martín-Serrano, Rubén Fernández-Santamaría, Isabel M. Jiménez-Sánchez, Adriana Ariza, Esther Barrionuevo, Teresa Posadas, María Salas, Tahía Diana Fernández, María José Torres and María Isabel Montañez

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating la...

Authors: Jean Bousquet, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Anto, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, Guido Iaccarino, Hubert Blain, Alessandro Fiocchi, G. Walter Canonica, Joao A. Fonseca, Alain Vidal, Hak-Jong Choi, Hyun Ju Kim, Vincent Le Moing…

Highlights and recent developments in allergic diseases in EAACI journals (2019)

The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

Authors: J. Bousquet, C. E. Grattan, C. A. Akdis, P. A. Eigenmann, K. Hoffmann-Sommergruber, I. Agache and M. Jutel

IgE-binding to vicilin-like antimicrobial peptides is associated with systemic reactions to macadamia nut

Macadamia nut can induce fatal allergic reactions and changes in dietary habits will raise their consumption in industrialised countries. Until now diagnosis of macadamia nut allergy by sIgE solely relies on t...

Authors: Anna M. Ehlers, Stefanie Rohwer, Henny G. Otten, Bettina Brix, Thuy-My Le, Waltraud Suer and André C. Knulst

Hereditary angioedema caused by a premature stop codon mutation in the SERPING1 gene

Hereditary angioedema with deficient and dysfunctional C1 inhibitor (C1-INH-HAE) is a rare genetic disorder. The majority of the cases with this disease are caused by mutations in the C1-inbitor gene SERPING1 and...

Authors: Ying-Yang Xu, Jian-Qing Gu and Yu-Xiang Zhi

Defining lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins

Authors: Rui Wang, Ashfaq Ghumra, Stella Cochrane, Lucy Fairclough, Richard Broughton, Louise V. Michaelson, Frederic Beaudoin and Marcos J. C. Alcocer

Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS)

A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the...

Authors: Lukas Jörg, Arthur Helbling, Daniel Yerly and Werner J. Pichler

Increasing incidence of anaphylaxis in Hong Kong from 2009 to 2019—discrepancies of anaphylaxis care between adult and paediatric patients

Anaphylaxis has been increasing in developed countries but there is very little published data on the burden of anaphylaxis and the pattern of adrenaline autoinjector (AAI) prescription from Asia. We aim to de...

Authors: Philip Hei Li, Agnes S. Y. Leung, Rebecca M. Y. Li, Ting-fan Leung, Chak-sing Lau and Gary W. K. Wong

Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens

Artemisia weed pollen allergy is important in the northern hemisphere. While over 350 species of this genus have been recorded, there has been no full investigation into whether different species may affect the a...

Authors: Lan Zhao, Wanyi Fu, Biyuan Gao, Yi Liu, Shandong Wu, Zhi Chen, Xianqi Zhang, Huiying Wang, Yan Feng, Xueyan Wang, Hongtian Wang, Tianfei Lan, Meiling Liu, Xuefeng Wang, Yuemei Sun, Fangmei Luo…

Correction to: Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases

An amendment to this paper has been published and can be accessed via the original article.

Authors: Arunas Valiulis, J. Bousquet, A. Veryga, U. Suprun, D. Sergeenko, S. Cebotari, D. Borelli, S. Pietikainen, J. Banys, I. Agache, N. E. Billo, A. Bush, I. Chkhaidze, L. Dubey, W. J. Fokkens, J. Grigg…

Retraction Note to: Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double-blind randomised controlled trial

An amendment to this paper has been published and can be accessed via the original article.

Authors: Robert Boyle, Nick Brown, Wen Chin Chiang, Chua Mei Chien, Michael Gold, Jonathan Hourihane, Jane Peake, Patrick Quinn, Raj Rao, Peter Smith, Mimi Tang, John Ziegler and John Warner

The role of antifungals in the management of patients with severe asthma

In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being life-threatening. Sensitisation to fungi, es...

Authors: W. Garth Rapeport, Kazuhiro Ito and David W. Denning

Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic

An increase in online searches on health topics may either mirror epidemiological changes or reflect media coverage. In the context of COVID-19, this is particularly relevant, as COVID-19 symptoms may be mista...

Authors: Bernardo Sousa-Pinto, Enrico Heffler, Aram Antó, Wienczyslawa Czarlewski, Anna Bedbrook, Bilun Gemicioglu, G. Walter Canonica, Josep M. Antó, João Almeida Fonseca and Jean Bousquet

Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivot...

Authors: Tim Delemarre, Natalie De Ruyck, Gabriele Holtappels, Claus Bachert and Elien Gevaert

Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa

Genome wide association studies (GWASs) have revealed several airway disease-associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic rhinosinusitis (CRS), however, is not yet...

Authors: Anu Laulajainen-Hongisto, Annina Lyly, Tanzeela Hanif, Kishor Dhaygude, Matti Kankainen, Risto Renkonen, Kati Donner, Pirkko Mattila, Tuomas Jartti, Jean Bousquet, Paula Kauppi and Sanna Toppila-Salmi

Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?

An amendment to this paper has been published and can be accessed via the original article.

Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

Validation of the DECA criteria for allergic conjunctivitis severity and control

Allergic conjunctivitis (AC) is usually associated to allergic rhinitis (AR), but the severity and control of ocular symptoms should be assessed independently to improve diagnosis and treatment. The criteria f...

Authors: M. Cesárea Sánchez-Hernández, Ana M. Navarro, Carlos Colás, Alfonso del Cuvillo, Joaquín Sastre, Joaquim Mullol and Antonio Valero

Fungal and bacterial microbiome dysbiosis and imbalance of trans-kingdom network in asthma

Fungal and bacterial microbiota play an important role in development of asthma. We aim to characterize airway microbiome (mycobiome, bacteriome) and functional genes in asthmatics and controls.

Authors: Chunrong Huang, Youchao Yu, Wei Du, Yahui Liu, Ranran Dai, Wei Tang, Ping Wang, Chenhong Zhang and Guochao Shi

Current transition management of adolescents and young adults with allergy and asthma: a European survey

Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare profes...

Authors: Ekaterina Khaleva, Marta Vazquez-Ortiz, Pasquale Comberiati, Audrey DunnGalvin, Helena Pite, Katharina Blumchen, Teresa Garriga-Baraut, Valerie Hox, Alexandra F. Santos, Claudia Gore, Rebecca C. Knibb, Cherry Alviani, Charlotte G. Mortz, Elizabeth Angier, Bettina Duca, Britt Jensen…

Primary non-adherence to inhaled medications measured with e-prescription data from Poland

Treatment adherence greatly influences the clinical outcomes in various fields of medicine, including management of asthma and COPD. With the recent implementation of a nationwide e-Health solutions in Poland,...

Authors: Grzegorz Kardas, Michał Panek, Piotr Kuna and Przemysław Kardas

Correction to: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

An amendment to this paper has been published and can be accessed via the original article.

Authors: Valerie Hox, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol…

Correction to: Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)

An amendment to this paper has been published and can be accessed via the original article.

Authors: C. A. Akdis, J. Bousquet, C. E. Grattan, P. A. Eigenmann, K. Hofmann-Sommergruber, I. Agache and M. Jutel

Initiating pollen sensitization – complex source, complex mechanisms

The mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion tha...

Authors: Lisa Pointner, Athanasios Bethanis, Michael Thaler, Claudia Traidl-Hoffmann, Stefanie Gilles, Fatima Ferreira and Lorenz Aglas

The association between airborne pollen monitoring and sensitization in the hot desert climate

Pollen is a major cause of allergic respiratory diseases. In Qatar, data on the presence and prevalence of allergenic airborne types of pollen is quite limited.

Authors: Maryam A. Al-Nesf, Dorra Gharbi, Hassan M. Mobayed, Blessing Reena Dason, Ramzy Mohammed Ali, Salma Taha, Amjad Tuffaha, Mehdi Adeli, Hisham A. Sattar and Maria del Mar Trigo

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) a...

Authors: Fariza Mishaal Saiema Badloe, Shauni De Vriese, Katarina Coolens, Carsten B. Schmidt-Weber, Johannes Ring, Jan Gutermuth and Inge Kortekaas Krohn

Allergen exposure chambers: implementation in clinical trials in allergen immunotherapy

Allergen exposure chambers (AECs) have been developed for controlled allergen challenges of allergic patients mimicking natural exposure. As such, these facilities have been utilized e.g., for proof of concept...

Authors: O. Pfaar and P. Zieglmayer

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-...

Authors: D. Ferastraoaru, H. J. Bax, C. Bergmann, M. Capron, M. Castells, D. Dombrowicz, E. Fiebiger, H. J. Gould, K. Hartmann, U. Jappe, G. Jordakieva, D. H. Josephs, F. Levi-Schaffer, V. Mahler, A. Poli, D. Rosenstreich…

Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis

One of the important pathogeneses of eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence of allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on th...

Authors: Yun Ma, Maojin Liang, Peng Tian, Xiang Liu, Hua Dang, Qiujian Chen, Hua Zou and Yiqing Zheng

Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients

Emerging data indicates that extracellular traps (ETs), structures formed by various immune cell types, may contribute to the pathology of noninfectious inflammatory diseases. Histone hypercitrullination is an...

Authors: Pawel Kuczia, Joanna Zuk, Teresa Iwaniec, Jerzy Soja, Jerzy Dropinski, Marta Malesa-Wlodzik, Lech Zareba, Jan G. Bazan, Anetta Undas and Stanislawa Bazan-Socha

Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper

Farmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respirator...

Authors: T. Sigsgaard, I. Basinas, G. Doekes, F. de Blay, I. Folletti, D. Heederik, A. Lipinska-Ojrzanowska, D. Nowak, M. Olivieri, S. Quirce, M. Raulf, J. Sastre, V. Schlünssen, J. Walusiak-Skorupa and A. Siracusa

Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. However, the molecular endotypes associated with CRSwNP with comorbid as...

Authors: Ming Wang, Xiangting Bu, Ge Luan, Liqing Lin, Yang Wang, Jianmin Jin, Luo Zhang and Chengshuo Wang

The disease burden in patients with respiratory allergies induced by house dust mites: a year-long observational survey in three European countries

House dust mite (HDM) allergens constitute the most frequent cause of persistent allergic rhinitis and asthma. The symptoms vary throughout the year but typically peak in spring, autumn and (to a lesser extent...

Authors: Pascal Demoly, Andrea Matucci, Oliviero Rossi and Carmen Vidal

Allergen Immunotherapy (AIT) in children: a vulnerable population with its own rights and legislation – summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019

Concerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use...

Authors: V. Mahler, D. Mentzer, A. Bonertz, A. Muraro, P. Eigenmann, J. Bousquet, S. Halken, O. Pfaar, M. Jutel, U. Wahn, S. Vieths and S. Kaul

Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis

A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis with nasal polyps (CRSwNP), the presence of which may adversely...

Authors: Enrico Heffler, Fabiana Saccheri, Marta Bartezaghi and Giorgio Walter Canonica

Digital transformation of health and care to sustain Planetary Health: The MASK proof-of-concept for airway diseases—POLLAR symposium under the auspices of Finland’s Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing

In December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the F...

Authors: Jean Bousquet, Josep M. Anto, Tari Haahtela, Pekka Jousilahti, Marina Erhola, Xavier Basagaña, Wienczyslawa Czarlewski, Mikaëla Odemyr, Susanna Palkonen, Mikael Sofiev, César Velasco, Anna Bedbrook, Rodrigo Delgado, Rostislav Kouznetsov, Mika Mäkelä, Yuliia Palamarchuk…

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model

Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti

Molecular approach to a patient’s tailored diagnosis of the oral allergy syndrome

Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic protei...

Authors: Claudia Alessandri, Rosetta Ferrara, Maria Livia Bernardi, Danila Zennaro, Lisa Tuppo, Ivana Giangrieco, Teresa Ricciardi, Maurizio Tamburrini, Maria Antonietta Ciardiello and Adriano Mari

Epinephrine delivery via EpiPen^® Auto-Injector or manual syringe across participants with a wide range of skin-to-muscle distances

Intramuscular (IM) injection of epinephrine (adrenaline) at the mid-anterolateral (AL) thigh is the international standard therapy for acute anaphylaxis. Concerns exist regarding implications of epinephrine au...

Authors: Margitta Worm, DucTung Nguyen, Russ Rackley, Antonella Muraro, George Du Toit, Tracey Lawrence, Hong Li, Kurt Brumbaugh and Magnus Wickman

Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome

Authors: Alejandra González Pérez, Antonio Carbonell Martínez, Ana Isabel Escudero Pastor, Cristina Navarro Garrido and Juan Carlos Miralles López

New approach to intermittent and mild asthma therapy: evolution or revolution in the GINA guidelines?

New recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. These recommendations provide very important changes to the management of asthma, especi...

Authors: Izabela Kuprys-Lipinska, Marta Kolacinska-Flont and Piotr Kuna

Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients

Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. Malassezia globosa, a skin resident fungus...

Authors: Sabine Altrichter, Pia Schumacher, Ola Alraboni, Yiyu Wang, Makiko Hiragun, Michihiro Hide and Marcus Maurer

Viral infections and wheezing–asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?

Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later lif...

Authors: Giovanni A. Rossi, Petr Pohunek, Wojciech Feleszko, Stefania Ballarini and Andrew A. Colin

Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most curren...

Authors: Jean Bousquet, Josep M. Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A. Akdis, Hubert Blain, G. Walter Canonica, Victoria Cardona, Alvaro A. Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna…

Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort

Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited.

Authors: Erik Melén, Anna Bergström, Inger Kull, Catarina Almqvist, Niklas Andersson, Anna Asarnoj, Magnus P. Borres, Antonis Georgellis, Göran Pershagen, Marit Westman, Marianne van Hage and Natalia Ballardini

EAACI anaphylaxis guidelines: systematic review protocol

Authors: Debra de Silva, Graham Roberts, Margitta Worm and Antonella Muraro