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  1. Content type: Letter to the Editor

    We report two patients with normocomplementaemic urticarial vasculitis with impressive response to omalizumab. This contrasts recent reports on hypocomplementaemic urticarial vasculitis syndrome, highlighting ...

    Authors: Marianne de Brito, Gisela Huebner, DedeeF Murrell, Peter Bullpitt and Karin Hartmann

    Citation: Clinical and Translational Allergy 2018 8:37

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  2. Content type: Review

    Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, As...

    Authors: Jean Bousquet, Josep M. Anto, Isabella Annesi-Maesano, Toni Dedeu, Eve Dupas, Jean-Louis Pépin, Landry Stephane Zeng Eyindanga, Sylvie Arnavielhe, Julia Ayache, Xavier Basagana, Samuel Benveniste, Nuria Calves Venturos, Hing Kin Chan, Mehdi Cheraitia, Yves Dauvilliers, Judith Garcia-Aymerich…

    Citation: Clinical and Translational Allergy 2018 8:36

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  3. Content type: Letter to the Editor

    Epithelial cell lines are often used to evaluate the effect of exogenous/endogenous stimuli on epithelial barrier function and innate immune responses in allergic airway diseases, without clear view on differe...

    Authors: Katleen Martens, Peter W. Hellings and Brecht Steelant

    Citation: Clinical and Translational Allergy 2018 8:40

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  4. Content type: Research

    A visual analogue scale (VAS) is a psychometric instrument widely used in the Rhinology field to subjectively quantify patient’s symptoms severity. In allergic rhinitis, VAS has been found to correlate well wi...

    Authors: Maria Doulaptsi, Emmanuel Prokopakis, Sven Seys, Benoit Pugin, Brecht Steelant and Peter Hellings

    Citation: Clinical and Translational Allergy 2018 8:32

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  5. Content type: Review

    The multi-disciplinary team approach is an effective model for patient care. Allied health professionals (AHPs) are an important part of such teams, bringing specific knowledge and skills related to the target...

    Authors: I. J. Skypala, N. W. de Jong, E. Angier, J. Gardner, I. Kull, D. Ryan, C. Venter, B. J. Vlieg-Boerstra and K. Grimshaw

    Citation: Clinical and Translational Allergy 2018 8:31

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  6. Content type: Research

    As the development of urbanization in China, the morbidity of allergic disease rise up prominently even in children, which may be partially associated with the excessively clean environment. It has been report...

    Authors: Jinyan Yu, Xiaoqiu Liu, Yanlei Li, Shanshan Meng, Fei Wu, Bingdi Yan, Yanjun Xue, Tiangang Ma, Junling Yang and Jing Liu

    Citation: Clinical and Translational Allergy 2018 8:34

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  7. Content type: Research

    Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has ...

    Authors: Jaap Akkerdaas, Muriel Totis, Brian Barnett, Erin Bell, Tom Davis, Thomas Edrington, Kevin Glenn, Gerson Graser, Rod Herman, Andre Knulst, Gregory Ladics, Scott McClain, Lars K. Poulsen, Rakesh Ranjan, Jean-Baptiste Rascle, Hector Serrano…

    Citation: Clinical and Translational Allergy 2018 8:30

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  8. Content type: Research

    The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity...

    Authors: Esben Eller, Antonella Muraro, Ronald Dahl, Charlotte Gotthard Mortz and Carsten Bindslev-Jensen

    Citation: Clinical and Translational Allergy 2018 8:29

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  9. Content type: Review

    Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE pla...

    Authors: Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun and Kunmei Ji

    Citation: Clinical and Translational Allergy 2018 8:27

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  10. Content type: Research

    Allergic rhinitis (AR) is a highly prevalent disease that generates high social and health care costs and also has a significant effect on quality of life and quality of sleep. It has also been related to some...

    Authors: R. Muñoz-Cano, P. Ribó, G. Araujo, E. Giralt, J. Sanchez-Lopez and A. Valero

    Citation: Clinical and Translational Allergy 2018 8:23

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  11. Content type: Research

    Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctiva...

    Authors: Janina Köther, Alicia Mandl, Silke Allekotte, Anatoli Astvatsatourov, Janin Chwieralski, Jan-Patrick Liedtke, Ursula Pieper-Fürst, Esther Raskopf, Kija Shah-Hosseini and Ralph Mösges

    Citation: Clinical and Translational Allergy 2018 8:28

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  12. Content type: Research

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy...

    Authors: Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang and Yueqi Sun

    Citation: Clinical and Translational Allergy 2018 8:24

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  13. Content type: Research

    The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countrie...

    Authors: Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská and Marek Malý

    Citation: Clinical and Translational Allergy 2018 8:19

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  14. Content type: Review

    The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resultin...

    Authors: Maria D’Amato, Antonio Molino, Giovanna Calabrese, Lorenzo Cecchi, Isabella Annesi-Maesano and Gennaro D’Amato

    Citation: Clinical and Translational Allergy 2018 8:20

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  15. Content type: Research

    The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. Th...

    Authors: Bertine M. J. Flokstra-de Blok, Thecla M. Brakel, Marian Wubs, Ben Skidmore, Janwillem W. H. Kocks, Joanne N. G. Oude Elberink, Marie-Louise A. Schuttelaar, Jantina L. van der Velde, Thys van der Molen and Anthony E. J. Dubois

    Citation: Clinical and Translational Allergy 2018 8:18

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  16. Content type: Research

    Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between...

    Authors: Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A. Camargo Jr, Mübeccel Akdis, Cezmi A. Akdis…

    Citation: Clinical and Translational Allergy 2018 8:22

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  17. Content type: Review

    Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often se...

    Authors: I. Doña, J. C. Caubet, K. Brockow, M. Doyle, E. Moreno, I. Terreehorst and M. J. Torres

    Citation: Clinical and Translational Allergy 2018 8:16

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  18. Content type: Research

    Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five...

    Authors: Rita Amaral, João A. Fonseca, Tiago Jacinto, Ana M. Pereira, Andrei Malinovschi, Christer Janson and Kjell Alving

    Citation: Clinical and Translational Allergy 2018 8:13

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  19. Content type: Review

    House dust mites are small arthropods that produce proteins—found in their feces, body parts, and eggs—that are major triggers of human allergies worldwide. The goal of this review is to describe the current m...

    Authors: Yubao Cui, Qiong Wang and Haoyuan Jia

    Citation: Clinical and Translational Allergy 2018 8:14

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  20. Content type: Research

    The pathogenesis of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is not fully understood. Our previous study reported that chemokine CCL27 was overexpressed in serum of SJS/TEN patients. The...

    Authors: Fang Wang, Yanting Ye, Ze-Yu Luo, Qian Gao, Di-Qing Luo and Xingqi Zhang

    Citation: Clinical and Translational Allergy 2018 8:12

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  21. Content type: Research

    The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A...

    Authors: Helen Neighbour, Mena Soliman, Lisa M. Steacy, Pascal Hickey, Beth Forbes, Mark Larché and Anne K. Ellis

    Citation: Clinical and Translational Allergy 2018 8:15

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  22. Content type: Brief communication

    Ambient air quality monitoring is a governmental duty that is widely carried out in order to detect non-biological (“chemical”) components in ambient air, such as particles of < 10 µm (PM10, PM2.5), ozone, sulphu...

    Authors: J. T. M. Buters, C. Antunes, A. Galveias, K. C. Bergmann, M. Thibaudon, C. Galán, C. Schmidt-Weber and J. Oteros

    Citation: Clinical and Translational Allergy 2018 8:9

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  23. Content type: Research

    Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the ...

    Authors: Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie and Stella Cochrane

    Citation: Clinical and Translational Allergy 2018 8:10

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  24. Content type: Research

    Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of b...

    Authors: Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J. Longhurst, Laurence Bouillet and Irmgard Andresen

    Citation: Clinical and Translational Allergy 2018 8:11

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  25. Content type: Research

    Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persisten...

    Authors: Paulo Camargos, Alessandra Affonso, Geralda Calazans, Lidiana Ramalho, Marisa L. Ribeiro, Nulma Jentzsch, Simone Senna and Renato T. Stein

    Citation: Clinical and Translational Allergy 2018 8:7

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  26. Content type: Letter to the Editor

    We performed a MeSH term-based bibliometric analysis aiming to assess the publication trends of EAACI journals, namely Allergy, Pediatric Allergy and Immunology (PAI) (from 1990 to 2015) and Clinical and Trans...

    Authors: Daniel Martinho-Dias, Bernardo Sousa-Pinto, Júlio Botelho-Souza, António Soares, Luís Delgado and João Almeida Fonseca

    Citation: Clinical and Translational Allergy 2018 8:6

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  27. Content type: Research

    Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways....

    Authors: Wei Tang, Steven G. Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M. Salter, Gail M. Gauvreau, Paul M. O’Byrne and Roma Sehmi

    Citation: Clinical and Translational Allergy 2018 8:5

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  28. Content type: Research

    Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various pra...

    Authors: Marjolein Vandekerckhove, Bart Van Droogenbroeck, Marc De Loose, Katleen Coudijzer, Marc Coppens, Philippe Gevaert and Hilde Lapeere

    Citation: Clinical and Translational Allergy 2018 8:3

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  29. Content type: Correction

    In the original version of this article [1], published on 23 August 2017, an incorrect version of Additional file 4 has been used. The corrected version of Additional file 4 is given in this correction.

    Authors: Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M. Fleischer, Ralf G. Heine, Michael Levin, Mario C. Vieira and Adam T. Fox

    Citation: Clinical and Translational Allergy 2018 8:4

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    The original article was published in Clinical and Translational Allergy 2017 7:26

  30. Content type: Research

    Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents...

    Authors: Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Osvaldo Correia and Luís Delgado

    Citation: Clinical and Translational Allergy 2018 8:2

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  31. Content type: Brief communication

    European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to dete...

    Authors: Maja A. Hofmann, Ana Giménez-Arnau, Werner Aberer, Carsten Bindslev-Jensen and Torsten Zuberbier

    Citation: Clinical and Translational Allergy 2018 8:1

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  32. Content type: Review

    On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. ...

    Authors: Peter W. Hellings, David Borrelli, Sirpa Pietikainen, Ioana Agache, Cezmi Akdis, Claus Bachert, Michael Bewick, Erna Botjes, Jannis Constantinidis, Wytske Fokkens, Tari Haahtela, Claire Hopkins, Maddalena Illario, Guy Joos, Valerie Lund, Antonella Muraro…

    Citation: Clinical and Translational Allergy 2017 7:49

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  33. Content type: Research

    In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) ...

    Authors: Mônica Versiani Nunes Pinheiro de Queiroz, Cristina Gonçalves Alvim, Álvaro A. Cruz and Laura Maria de Lima Belizário Facury Lasmar

    Citation: Clinical and Translational Allergy 2017 7:48

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  34. Content type: Review

    Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different com...

    Authors: Alberto Alvarez-Perea, Luciana Kase Tanno and María L. Baeza

    Citation: Clinical and Translational Allergy 2017 7:45

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  35. Content type: Review

    Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and...

    Authors: M. Fröhlich, M. Pinart, T. Keller, A. Reich, B. Cabieses, C. Hohmann, D. S. Postma, J. Bousquet, J. M. Antó, T. Keil and S. Roll

    Citation: Clinical and Translational Allergy 2017 7:44

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  36. Content type: Review

    The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

    Authors: Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W. Hellings and Ioana Agache

    Citation: Clinical and Translational Allergy 2017 7:46

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  37. Content type: Research

    Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was t...

    Authors: Andrzej Bożek, Krzysztof Kołodziejczyk, Renata Kozłowska and Giorgio Walter Canonica

    Citation: Clinical and Translational Allergy 2017 7:43

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  38. Content type: Review

    Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an im...

    Authors: Yumei Liu, Jianglong Peng, Ying Zhou and Yubao Cui

    Citation: Clinical and Translational Allergy 2017 7:41

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  39. Content type: Research

    The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storag...

    Authors: Mark A. Blankestijn, André C. Knulst, Edward F. Knol, Thuy-My Le, Heike Rockmann, Henny G. Otten and Rob J. B. Klemans

    Citation: Clinical and Translational Allergy 2017 7:42

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  40. Content type: Research

    Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may...

    Authors: Line K. Tannert, Sidsel Falkencrone, Charlotte G. Mortz, Carsten Bindslev-Jensen and Per Stahl Skov

    Citation: Clinical and Translational Allergy 2017 7:40

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  41. Content type: Brief communication

    Adherence to medication is crucial for achieving treatment control in chronic obstructive lung diseases. This study refers to the “necessity-concerns framework” and examines the associations between beliefs a...

    Authors: Susanne Brandstetter, Tamara Finger, Wiebke Fischer, Magdalena Brandl, Merle Böhmer, Michael Pfeifer and Christian Apfelbacher

    Citation: Clinical and Translational Allergy 2017 7:39

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  42. Content type: Editorial

    The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local aller...

    Authors: Cristoforo Incorvaia, Nicola Fuiano, Irene Martignago, Bruna L. Gritti and Erminia Ridolo

    Citation: Clinical and Translational Allergy 2017 7:38

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  43. Content type: Review

    A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, i...

    Authors: J. Bousquet, G. L. Onorato, C. Bachert, M. Barbolini, A. Bedbrook, L. Bjermer, J. Correia de Sousa, N. H. Chavannes, A. A. Cruz, E. De Manuel Keenoy, P. Devillier, J. Fonseca, S. Hun, T. Kostka, P. W. Hellings, M. Illario…

    Citation: Clinical and Translational Allergy 2017 7:37

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