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  1. Content type: Review

    Recommendations on contraindications to allergen immunotherapy (AIT) have been independently developed by National and International Societies/Academies. AIT contraindications are mainly based on case reports,...

    Authors: C. Pitsios, M. Tsoumani, M. B. Bilò, G. J. Sturm, P. Rodríguez del Río, R. Gawlik, F. Ruëff, G. Paraskevopoulos, E. Valovirta, O. Pfaar, M. A. Calderón and P. Demoly

    Citation: Clinical and Translational Allergy 2019 9:45

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  2. Content type: Review

    In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support th...

    Authors: J. Jean Bousquet, Holger J. Schünemann, Alkis Togias, Marina Erhola, Peter W. Hellings, Torsten Zuberbier, Ioana Agache, Ignacio J. Ansotegui, Josep M. Anto, Claus Bachert, Sven Becker, Martin Bedolla-Barajas, Michael Bewick, Sinthia Bosnic-Anticevich, Isabelle Bosse, Louis P. Boulet…

    Citation: Clinical and Translational Allergy 2019 9:44

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  3. Content type: Research

    Asthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA2LEN) que...

    Authors: Afshin Ostovar, Wytske J. Fokkens, Safoora Pordel, Ali Movahed, Khadijeh Ghasemi, Maryam Marzban and Shokrollah Farrokhi

    Citation: Clinical and Translational Allergy 2019 9:43

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  4. Content type: Research

    Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship...

    Authors: David B. Price, Sinthia Bosnic-Anticevich, Ian D. Pavord, Nicolas Roche, David M. G. Halpin, Leif Bjermer, Omar S. Usmani, Guy Brusselle, Simon Wan Yau Ming and Sarang Rastogi

    Citation: Clinical and Translational Allergy 2019 9:41

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  5. Content type: Letter to the Editor

    The Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps be...

    Authors: Adam Fox, Trevor Brown, Joanne Walsh, Carina Venter, Rosan Meyer, Anna Nowak-Wegrzyn, Michael Levin, Hannah Spawls, Jolene Beatson, Marie-Therese Lovis, Mario C. Vieira and David Fleischer

    Citation: Clinical and Translational Allergy 2019 9:40

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  6. Content type: Letter to the Editor

    In two independent microarray studies involving primary airway epithelial cells, the relative gene expression of TMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for fu...

    Authors: Naiya B. Patel, Lorena A. Ostilla, Lyda Cuervo-Pardo, Sergejs Berdnikovs and Sergio E. Chiarella

    Citation: Clinical and Translational Allergy 2019 9:38

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  7. Content type: Research letter

    This multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14–55 years and had allergic rhinitis and/or asthma, which was due...

    Authors: Beristain Ana and Fernando de la Torre

    Citation: Clinical and Translational Allergy 2019 9:39

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  8. Content type: Review

    Eosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and co...

    Authors: Polliana Mihaela Leru

    Citation: Clinical and Translational Allergy 2019 9:36

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  9. Content type: Research

    Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling in subcutaneous or submucosal tissues. Symptoms often begin by age 5–11 years and worsen during puberty, b...

    Authors: Anette Bygum, Teresa Caballero, Anete S. Grumach, Hilary J. Longhurst, Laurence Bouillet, Werner Aberer, Andrea Zanichelli, Jaco Botha, Irmgard Andresen and Marcus Maurer

    Citation: Clinical and Translational Allergy 2019 9:37

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  10. Content type: Research

    Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of ...

    Authors: Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park and Young-Min Ye

    Citation: Clinical and Translational Allergy 2019 9:33

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  11. Content type: Letter to the Editor

    Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients...

    Authors: Zonne L. M. Hofman, Nikki van West, C. Erik Hack, André C. Knulst, Coen Maas and Heike Röckmann

    Citation: Clinical and Translational Allergy 2019 9:35

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  12. Content type: Research

    The atopic syndrome consists of heterogeneous manifestations, in which multiple associated genetic loci have recently been identified. It is hypothesized that immune dysregulation plays a role in the pathogene...

    Authors: Jill de Wit, Rogier T. A. van Wijck, Virgil A. S. H. Dalm, Kristen L. Snyder, Joan E. E. Totté, Suzanne G. M. A. Pasmans and Peter J. van der Spek

    Citation: Clinical and Translational Allergy 2019 9:34

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  13. Content type: Research

    The objective of this analysis was to compare the multiplex ImmunoCAP ISAC (Thermo Fisher Scientific, Sweden) and the multiplex Alex Allergy Explorer (Macro Array Diagnostics GmbH, Austria) platform on specifi...

    Authors: Jana Bojcukova, Tomas Vlas, Peter Forstenlechner and Petr Panzner

    Citation: Clinical and Translational Allergy 2019 9:31

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  14. Content type: Letter to the Editor

    In daily practice, one-third of sesame allergic patients, confirmed by clinical history or food challenge, do not show any detectable specific IgE using current diagnostics. Currently used sesame extracts are ...

    Authors: Anna M. Ehlers, Madlen Rossnagel, Bettina Brix, Mark A. Blankestijn, Thuy-My Le, Waltraud Suer, Henny G. Otten and André C. Knulst

    Citation: Clinical and Translational Allergy 2019 9:32

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  15. Content type: Research

    Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical tre...

    Authors: Lien Calus, Nicholas Van Bruaene, Cedric Bosteels, Sarah Dejonckheere, Thibaut Van Zele, Gabrielle Holtappels, Claus Bachert and Philippe Gevaert

    Citation: Clinical and Translational Allergy 2019 9:30

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  16. Content type: Review

    Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates th...

    Authors: Ralph Mösges, Antonio Valero Santiago, Silke Allekotte, Nilufar Jahed, Anatoli Astvatsatourov, Angelika Sager and Jaime Sánchez-López

    Citation: Clinical and Translational Allergy 2019 9:29

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  17. Content type: Research

    Altered gut microbiota is implicated in cow’s milk allergy (CMA) and differs markedly from healthy, breastfed infants. Infants who suffer from severe CMA often rely on cow’s milk protein avoidance and, when br...

    Authors: Harm Wopereis, Marleen T. J. van Ampting, Aysun Cetinyurek-Yavuz, Rob Slump, David C. A. Candy, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, Adam T. Fox, Neil Shah, Guus Roeselers, Lucien F. Harthoorn, Louise J. Michaelis, Jan Knol and Christina E. West

    Citation: Clinical and Translational Allergy 2019 9:27

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  18. Content type: Research

    The identification of house dust mite (HDM) allergens and epitopes is important for allergy diagnosis and treatment. We sought to identify the Dermatophagoides pteronyssinus group 24 allergen (Der p 24) and to id...

    Authors: Ze-Lang Cai, Jia-Jie Chen, Zhen Zhang, Yi-Bo Hou, Yong-shen He, Jin-Lyu Sun and Kunmei Ji

    Citation: Clinical and Translational Allergy 2019 9:28

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  19. Content type: Letter to the Editor

    The clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recomm...

    Authors: Morten J. Christensen, Esben Eller, Charlotte G. Mortz, Knut Brockow and Carsten Bindslev-Jensen

    Citation: Clinical and Translational Allergy 2019 9:26

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  20. Content type: Research

    Adverse psychosocial working conditions—in particular poor job decision latitude and poor social support at work—may impair the effective implementation of asthma self-management behaviour at work and may be a...

    Authors: Katherina Heinrichs, Stefan Hummel, Jalal Gholami, Konrad Schultz, Jian Li, Aziz Sheikh and Adrian Loerbroks

    Citation: Clinical and Translational Allergy 2019 9:25

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  21. Content type: Review

    Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive...

    Authors: Katrine Y. Baumann, Martin K. Church, Geraldine F. Clough, Sven Roy Quist, Martin Schmelz, Per Stahl Skov, Chris D. Anderson, Line Kring Tannert, Ana Maria Giménez-Arnau, Stefan Frischbutter, Jörg Scheffel and Marcus Maurer

    Citation: Clinical and Translational Allergy 2019 9:24

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  22. Content type: Correction

    Following publication of the original article [1], the authors reported that one of the authors’ name was spelled incorrectly.

    Authors: Filip Raciborski, Jean Bousquet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z. Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska…

    Citation: Clinical and Translational Allergy 2019 9:23

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    The original article was published in Clinical and Translational Allergy 2019 9:4

  23. Content type: Research

    The prevalence of self-experienced adverse reactions to foods seems to have an increasing trend in both adults and children. However, it is unclear if the prevalence of food hypersensitivity in the Swedish adu...

    Authors: G. Rentzos, L. Johanson, Emma Goksör, E. Telemo, Bo Lundbäck and L. Ekerljung

    Citation: Clinical and Translational Allergy 2019 9:22

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  24. Content type: Research

    Evidence from observational comparative effectiveness research (CER) is ranked below that from randomized controlled trials in traditional evidence hierarchies. However, asthma observational CER studies repre...

    Authors: Jonathan D. Campbell, Robert Perry, Nikolaos G. Papadopoulos, Jerry Krishnan, Guy Brusselle, Alison Chisholm, Leif Bjermer, Michael Thomas, Eric van Ganse, Maarten van den Berge, Jennifer Quint, David Price and Nicolas Roche

    Citation: Clinical and Translational Allergy 2019 9:21

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  25. Content type: Research

    A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observa...

    Authors: Nicolas Roche, Jonathan D. Campbell, Jerry A. Krishnan, Guy Brusselle, Alison Chisholm, Leif Bjermer, Mike Thomas, Eric van Ganse, Maarten van den Berge, George Christoff, Jennifer Quint, Nikolaos G. Papadopoulos and David Price

    Citation: Clinical and Translational Allergy 2019 9:20

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  26. Content type: Research

    In wheat-dependent exercise-induced anaphylaxis (WDEIA), cofactors such as exercise, acetylsalicylic acid (ASA), alcohol or unfavorable climatic conditions are required to elicit a reaction to wheat products. ...

    Authors: Katharina Anne Scherf, Ann-Christin Lindenau, Luzia Valentini, Maria Carmen Collado, Izaskun García-Mantrana, Morten Christensen, Dirk Tomsitz, Claudia Kugler, Tilo Biedermann and Knut Brockow

    Citation: Clinical and Translational Allergy 2019 9:19

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  27. Content type: Research

    The correct classification of an adverse drug reaction (ADR) as allergy (immunological) or intolerance (non-immunological) has important clinical implications. The aim of this study was to examine the ability ...

    Authors: Sepehr Shakib, Gillian E. Caughey, Jie Shen Fok and William B. Smith

    Citation: Clinical and Translational Allergy 2019 9:18

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  28. Content type: Research

    Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approa...

    Authors: Rita Amaral, Ana M. Pereira, Tiago Jacinto, Andrei Malinovschi, Christer Janson, Kjell Alving and João A. Fonseca

    Citation: Clinical and Translational Allergy 2019 9:17

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  29. Content type: Review

    Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multi...

    Authors: J. Bousquet, A. Bedbrook, W. Czarlewski, G. L. Onorato, S. Arnavielhe, D. Laune, E. Mathieu-Dupas, J. Fonseca, E. Costa, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, M. Illario, E. Menditto, G. W. Canonica, L. Cecchi…

    Citation: Clinical and Translational Allergy 2019 9:16

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  30. Content type: Letter to the Editor

    Cosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since all...

    Authors: Karolina Dumycz, Katarzyna Kunkiel and Wojciech Feleszko

    Citation: Clinical and Translational Allergy 2019 9:15

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  31. Content type: Research

    The distribution of Pooideae species varies across Europe. Especially, Timothy is less represented in Southern than in Northern Europe. Since allergenic cross-reactivity between pollens from different grasses ...

    Authors: Thierry Batard, Amparo Sanjuan, Laure Denis, Hélène Nguyen, Armelle Montagut, Joaquín Sastre, Sabina Rak and Jean F. Cuiné

    Citation: Clinical and Translational Allergy 2019 9:13

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  32. Content type: Research

    Skin prick testing is the first-line interventional method to diagnose IgE mediated allergic diseases. Methodological differences in manufacturing processes and extract standardization may lead to variations i...

    Authors: Ruperto González-Pérez, Paloma Poza-Guedes, Yvelise Barrios del Pino, Víctor Matheu and Inmaculada Sánchez-Machín

    Citation: Clinical and Translational Allergy 2019 9:14

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  33. Content type: Research

    Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perce...

    Authors: N. Tsolakis, L. Nordvall, C. Janson, N. Rydell, A. Malinovschi and K. Alving

    Citation: Clinical and Translational Allergy 2019 9:12

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  34. Content type: Research

    Japanese cedar (JC) pollinosis is a serious type I allergic disease in Japan. Although subcutaneous immunotherapy and sublingual immunotherapy have been applied to treat JC pollinosis, high doses of allergens ...

    Authors: Shinya Takaishi, Saburo Saito, Minori Kamada, Nobuyoshi Otori, Hiromi Kojima, Kenjiro Ozawa and Fumio Takaiwa

    Citation: Clinical and Translational Allergy 2019 9:11

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  35. Content type: Letter to the Editor

    Hereditary angioedema (HAE) is a life-threatening disease characterized by recurrent episodes of subcutaneous and mucosal swellings and abdominal cramping. Corticosteroids and antihistamines, which are usually...

    Authors: Andreas Recke, Elisabeth G. Massalme, Uta Jappe, Lars Steinmüller-Magin, Julia Schmidt, Yorck Hellenbroich, Irina Hüning, Gabriele Gillessen-Kaesbach, Detlef Zillikens and Karin Hartmann

    Citation: Clinical and Translational Allergy 2019 9:9

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  36. Content type: Research

    Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic mu...

    Authors: Filip Raciborski, Jean Bousqet, Andrzej Namysłowski, Edyta Krzych-Fałta, Aneta Tomaszewska, Barbara Piekarska, Piotr Samel-Kowalik, Artur Z. Białoszewski, Artur Walkiewicz, Agnieszka Lipiec, Oksana Wojas, Krzysztof Samoliński, Anna Szylling, Wojciech Zieliński, Adam Sybilski, Aleksandra Grąbczewska…

    Citation: Clinical and Translational Allergy 2019 9:4

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    The Correction to this article has been published in Clinical and Translational Allergy 2019 9:23

  37. Content type: Letter to the Editor

    Food allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such...

    Authors: Victoria Thörnqvist, Roelinde Middelveld, Hay Mar Wai, Natalia Ballardini, Evalill Nilsson, Jennie Strömquist, Staffan Ahlstedt, Lennart Jan Nilsson and Jennifer L. P. Protudjer

    Citation: Clinical and Translational Allergy 2019 9:10

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  38. Content type: Review

    Allergic rhinitis (AR) affects 23–30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontr...

    Authors: P. W. Hellings, B. Pugin, G. Mariën, C. Bachert, C. Breynaert, D. M. Bullens, J. L. Ceuppens, G. Clement, T. Cox, D. Ebo, P. Gevaert, S. Halewyck, V. Hox, K. Ladha, R. Jacobs, P. Rombaux…

    Citation: Clinical and Translational Allergy 2019 9:1

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  39. Content type: Research

    Atopic dermatitis (AD) is a complex heterogeneous chronic inflammatory skin disease. Specific IgE antibodies against autoantigens have been observed in a subgroup of AD patients, however, little is known about...

    Authors: Maria Mikus, Catharina Johansson, Nathalie Acevedo, Peter Nilsson and Annika Scheynius

    Citation: Clinical and Translational Allergy 2019 9:6

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  40. Content type: Review

    Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patie...

    Authors: A. Valiulis, J. Bousquet, A. Veryga, U. Suprun, D. Sergeenko, S. Cebotari, D. Borelli, S. Pietikainen, J. Banys, I. Agache, N. E. Billo, A. Bush, I. Chkhaidze, L. Dubey, W. J. Fokkens, J. Grigg…

    Citation: Clinical and Translational Allergy 2019 9:7

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  41. Content type: Review

    The high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well-trained specialists. However, the ...

    Authors: N. Fyhrquist, T. Werfel, M. B. Bilò, N. Mülleneisen and R. Gerth van Wijk

    Citation: Clinical and Translational Allergy 2019 9:3

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  42. Content type: Research

    Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infant...

    Authors: Adam T. Fox, Harm Wopereis, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, David C. A. Candy, Neil Shah, Christina E. West, Johan Garssen, Lucien F. Harthoorn, Jan Knol and Louise J. Michaelis

    Citation: Clinical and Translational Allergy 2019 9:5

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  43. Content type: Review

    There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influence...

    Authors: Ozlem Keskin, Niloufar Farzan, Esra Birben, Hayriye Akel, Cagatay Karaaslan, Anke H. Maitland-van der Zee, Michael E. Wechsler, Susanne J. Vijverberg and Omer Kalayci

    Citation: Clinical and Translational Allergy 2019 9:2

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  44. Content type: Research

    The relationship between smoking, household pollution, dual exposure and severity of asthma in adults has not been sufficiently studied. We examined and compared the effects of cigarette smoking, domestic wood...

    Authors: Andréia Guedes Oliva Fernandes, Carolina de Souza-Machado, Gabriela Pimentel Pinheiro, Sergio Telles de Oliva, Raquel Cristina Lins Mota, Valmar Bião de Lima, Constança Sampaio Cruz, José Miguel Chatkin and Álvaro A. Cruz

    Citation: Clinical and Translational Allergy 2018 8:48

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  45. Content type: Research

    Vitamin D has been reported to be associated with many allergic diseases. There are a limited number of the studies of vitamin D supplementation in patients with chronic spontaneous urticaria (CSU). This study...

    Authors: Papapit Tuchinda, Kanokvalai Kulthanan, Leena Chularojanamontri, Sittiroj Arunkajohnsak and Sutin Sriussadaporn

    Citation: Clinical and Translational Allergy 2018 8:51

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  46. Content type: Research

    Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure...

    Authors: Rui Zheng, Dan Wang, Kai Wang, Wen-Xiang Gao, Qin-Tai Yang, Li-Jie Jiang, Min Zhou, Yu-Jie Cao, Jianbo Shi and Yueqi Sun

    Citation: Clinical and Translational Allergy 2018 8:50

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  47. Content type: Review

    The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

    Authors: J. Bousquet, C. A. Akdis, C. Grattan, P. A. Eigenmann, K. Hoffmann-Sommergruber, P. W. Hellings and I. Agache

    Citation: Clinical and Translational Allergy 2018 8:49

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