Microarrayed Jug r 1 shows the best diagnostic performance in walnut allergy
© Pedrosa et al; licensee BioMed Central Ltd. 2015
Published: 30 March 2015
Several walnut (WN) allergens have been identified to date: Jug r 1 (2S albumin), Jug r 2 (7S globulin), Jug r 3 (LTP), Jug r 4 (11S globulin) and Jug r 5 (profilin), but their clinical significance is still to be determined in some cases. Allergen microarray (ISAC) provides information for three of these allergens.
The aim of the study was to determine the importance of component resolved diagnosis in WN allergic patients.
Ninety children suspected to have allergy to fruit, nuts and/or legumes were selected. Patients were classified as allergic if they presented at least 2 reactions unequivocally related to WN ingestion in the last 2 years. Patients were defined as tolerant if they consumed WN on a regular basis. Clinical questionnaire, skin prick test (SPT), total and specific IgE and ImmunoCAP ISAC (Thermo Fisher) were performed.
Diagnostic performance of walnut allergens (MAISAC)
Jug r 1
Jug r 2
Jug r 3
LR test +
LR test -
Post Test + Probability
Post Test - Probability
In conclusion, Jug r 1-sIgE is the best discriminating allergen in WN allergic patients.
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