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Sensitisation to peanut LTP (rAra h 9) in children allergic to peach


Non-specific lipid transfer proteins (LTPs) are panallergens present in plant foods and are recognized as maior allergens in patients allergic to Rosaceae family fruits from the Mediterranean area. On the contrary, seed storage proteins are the most important allergens in peanut allergy worldwide, although some authors from Southern Europe found Ara h 9 (peanut LTP) as the maior allergen. The aim of the study was to analyze the sensitization to Ara h 9 in children allergic to peach, and the association with clinical tolerance to peanut.

Patients and methods

Thirty-three children with clinical history of peach allergy and specific IgE antibodies to Pru p 3 were included. Seventeen children allergic to peanut were used as the control group. Specific IgE to peanut extract, nPru p 3, rAra h 9 and rAra h 2 were determined by ImmunoCAP (Thermo Fisher). Titers higher than 0.34 KUA/L were considered positive. The clinical tolerance to peanut was evaluated by a questionnaire administered by the allergist.


The mean age of the study group was 6.7 years (SD 3.4), and the relation male/female 24/26. Twenty-four (72.7%) children allergic to peach had positive specific IgE antibodies to peanut extract and 28 (84.8%) to rAra h 9. There was a high association between nPru p 3- and rArah 9-specific IgE levels (R2=0.925; p<0.001)(Fig. 1). In this group 16 children (48.5%) referred good tolerance to peanut ingestion, 10 (30.3%) had never eaten it, and 7 (21.2%) had suffered allergic reactions related with the nut.

Figure 1
figure 1

Correlation between nPru p 3 and rAra h 9 levels (kU/L).

In the peanut allergic group 14 (82.4%) children had positive IgE antibodies to rAra h 2. Only 3 (17.6%) children had specific IgE to rAra h 9, and all of them had also IgE to rAra h 2.


The majority of children sensitized to Pru p 3 had specific IgE antibodies to Ara h 9 and to the whole peanut extract. At least a half of them can eat peanut with good tolerance. On the contrary, children allergic to peanut recognized more frequently Ara h 2.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Boyano-Martinez, T., Pedrosa, M., Garcia-Ara, C. et al. Sensitisation to peanut LTP (rAra h 9) in children allergic to peach. Clin Transl Allergy 5 (Suppl 3), P131 (2015).

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