Articles

The state of asthma epidemiology: an overview of systematic reviews and their quality

Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease. Building on this work, we aimed to investigate the qu...

Authors: Jon Genuneit, Annina M. Seibold, Christian J. Apfelbacher, George N. Konstantinou, Jennifer J. Koplin, Stefania La Grutta, Kirsty Logan, Carsten Flohr and Michael R. Perkin

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

Cashew nut, pistachio nut and mango belong to the Anacardiaceae family and are botanically related. Therefore, cashew nut sensitised children are frequently advised to eliminate cashew nuts and pistachio nuts fro...

Authors: J. P. M. van der Valk, R. el Bouche, R. Gerth van Wijk, H. de Groot, H. J. Wichers, A. E. J. Dubois and N. W. de Jong

Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America

Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare ...

Authors: M. J. Torres, A. Romano, G. Celik, P. Demoly, D. A. Khan, E. Macy, M. Park, K. Blumenthal, W. Aberer, M. Castells, A. Barbaud, C. Mayorga and P. Bonadonna

Galectin-3: an early predictive biomarker of modulation of airway remodeling in patients with severe asthma treated with omalizumab for 36 months

Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined ...

Authors: Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto and Giorgio Walter Canonica

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Authors: J. Bousquet, J. Farrell, G. Crooks, P. Hellings, E. H. Bel, M. Bewick, N. H. Chavannes, J. Correia de Sousa, A. A. Cruz, T. Haahtela, G. Joos, N. Khaltaev, J. Malva, A. Muraro, M. Nogues, S. Palkonen…

Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria

Treatment with second-generation antihistamines is recommended in patients with chronic spontaneous urticaria (CSU). Some patients remain unresponsive even after up-dosing up to fourfold. Many third line treat...

Authors: Mignon T. van den Elzen, Harmieke van Os-Medendorp, Imke van den Brink, Karin van den Hurk, Ouliana I. Kouznetsova, Alexander S. H. J. Lokin, Anna-Marijke Laheij-de Boer, Heike Röckmann, Carla A. F. M. Bruijnzeel-Koomen and André C. Knulst

Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA²LEN) Survey

Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases.

Authors: Vanessa Garcia-Larsen, Rhonda Arthur, James F. Potts, Peter H. Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brożek, Joanna Makowska, Marek L. Kowalski, Trine Thilsing, Thomas Keil, Paolo M. Matricardi, Kjell Torén, Thibaut van Zele…

Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. On...

Authors: Nicolaj Brandt, Lene H. Garvey, Ulla Bindslev-Jensen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen and Charlotte G. Mortz

Looking forward to new targeted treatments for chronic spontaneous urticaria

The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease...

Authors: Emek Kocatürk, Marcus Maurer, Martin Metz and Clive Grattan

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2)...

Authors: J. Bousquet, P. W. Hellings, I. Agache, A. Bedbrook, C. Bachert, K. C. Bergmann, M. Bewick, C. Bindslev-Jensen, S. Bosnic-Anticevitch, C. Bucca, D. P. Caimmi, P. A. M. Camargos, G. W. Canonica, T. Casale, N. H. Chavannes, A. A. Cruz…

Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach

Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and a...

Authors: Diana Margarida Gonçalves Solha Pereira da Silva, Teresa Maria Silva Vieira, Ana Maria Alves Pereira, André Miguel Afonso de Sousa Moreira and José Luís Dias Delgado

Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals

Sensitization to hazelnut (HN) is frequent and requires clarification to determine whether this sensitization is clinically relevant. The aim of this study was to investigate basophil activation profiles in HN...

Authors: Bianca Lötzsch, Sabine Dölle, Stefan Vieths and Margitta Worm

Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity

Although total IgE levels have been proposed as a biomarker for disease severity in atopic dermatitis (AD) and are increased in the majority of AD patients, they do not correlate with disease severity during s...

Authors: J. L. Thijs, K. Knipping, C. A. F. Bruijnzeel-Koomen, J. Garssen, M. S. de Bruin-Weller and D. J. Hijnen

A mutually beneficial collaboration between the European Academy of Allergy and Clinical Immunology Junior Members and Clinical and Translational Allergy

The European Academy of Allergy and Clinical Immunology (EAACI) Junior Members (JM) comprise the largest EAACI section with around 4000 clinicians and scientists under 35 years of age working in the field of a...

Authors: Peter Valentin Tomazic, Anke Graessel, Diana Silva, Ibon Eguiluz-Gracia, George V. Guibas, Clive Grattan, Jean Bousquet and Olympia Tsilochristou

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al...

Authors: M. A. Calderon, P. Demoly, T. Casale, C. A. Akdis, C. Bachert, M. Bewick, B. M. Bilò, B. Bohle, S. Bonini, A. Bush, D. P. Caimmi, G. W. Canonica, V. Cardona, A. M. Chiriac, L. Cox, A. Custovic…

4th Pediatric Allergy and Asthma Meeting (PAAM)

WORKSHOP 4: Challenging clinical scenarios (CS01–CS06)

Authors: S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok, Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis, Inês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais-Almeida…

Hypothesis: may e-cigarette smoking boost the allergic epidemic?

Authors: Jean Bousquet, Claus Bachert, Laura Crotty Alexander and Frank T. Leone

Standardization of double blind placebo controlled food challenge with soy within a multicentre trial

Multicentre trials investigating food allergies by double blind placebo controlled food challenges (DBPCFC) need standardized procedures, challenge meals and evaluation criteria. We aimed at developing a stand...

Authors: R. Treudler, A. Franke, A. Schmiedeknecht, B. K. Ballmer-Weber, M. Worm, T. Werfel, U. Jappe, T. Biedermann, J. Schmitt, R. Brehler, A. Kleinheinz, J. Kleine-Tebbe, H. Brüning, F. Ruëff, J. Ring, J. Saloga…

6th International Symposium on Molecular Allergology (ISMA)

ORAL ABSTRACTS

Authors: Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges, Christiane Lehners, Martine Morisset, Bernadette Eberlein, Tilo Biedermann, Markus Ollert, Sabrina Wildner, Teresa Stemeseder, Regina Freier, Peter Briza, Roland Lang, Eva Batanero, Mayte Villalba…

Impaired health-related quality of life in adolescents with allergy to staple foods

Cow’s milk, hen’s egg and wheat are staple foods in a typical western diet. Despite the ubiquity of these foods, the impact of staple food allergy on health-related quality of life (HRQL) amongst adolescents i...

Authors: Jennifer Lisa Penner Protudjer, Sven-Arne Jansson, Roelinde Middelveld, Eva Östblom, Sven-Erik Dahlén, Marianne Heibert Arnlind, Ulf Bengtsson, Ingrid Kallström-Bengtsson, Birgitta Marklund, Georgios Rentzos, Ann-Charlotte Sundqvist, Johanna Åkerström and Staffan Ahlstedt

Proficiency testing of skin prick testers as part of a quality assurance system

Skin prick test is an important diagnostic procedure in clinical allergy but documentation of the quality is often missing.

Authors: Hans-Jørgen Malling, Pernille Allesen-Holm, Lisbeth Sys Karved and Lars K. Poulsen

Cost utility analysis of the SQ^® HDM SLIT-tablet in house dust mite allergic asthma patients in a German setting

Asthma affects an estimated 300 million people worldwide with the condition associated with significant healthcare utilisation costs and a large impact on patient quality of life. The SQ^® HDM SLIT-tablet (ACARIZA...

Authors: J. Hahn-Pedersen, M. Worm, W. Green, J. Nørgaard Andreasen and M. Taylor

A qualitative study of the allergy testing experiences, views and preferences of adult patients

Patients can be tested for IgE sensitivities with in vivo or in vitro testing, but patients’ experiences of different allergy test modalities have not been studied. The objective of this study was to investiga...

Authors: Clare E. Brown, Christina J. Jones, Laura Stuttaford, Annalee Robertson, Rabia S. Rashid and Helen E. Smith

7th drug hypersensitivity meeting: part one

Oral Abstracts

Authors: Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed, Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly, Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters…

7th Drug hypersensitivity meeting: part two

Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)

Authors: Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez, Jaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De Rojas, Emre Ali Acar, Ayse Aktas, Aylin Türel Ermertcan…

Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood

The results of studies on the associations of childhood excessive weight/obesity and physical activity with atopic sensitization and atopic diseases are inconsistent. We studied the associations of anthropomet...

Authors: Kristine Kjer Byberg, Geir Egil Eide, Michele R. Forman, Pétur Benedikt Júlíusson and Knut Øymar

Improvement of sleep in patients with chronic idiopathic/spontaneous urticaria treated with omalizumab: results of three randomized, double-blind, placebo-controlled studies

Patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) report difficulty with sleep.

Authors: Ana M. Gimenéz-Arnau, Sheldon Spector, Evgeniya Antonova, Benjamin Trzaskoma, Karin Rosén, Theodore A. Omachi, Donald Stull, Maria-Magdalena Balp and Thomas Murphy

Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study

Atopic diseases including asthma, rhinitis and eczema have increased in the second half of the past century. This has been well studied among children and adolescents but with the exception of asthma to a muc...

Authors: Erik P. Rönmark, Linda Ekerljung, Roxana Mincheva, Sigrid Sjölander, Stig Hagstad, Göran Wennergren, Eva Rönmark, Jan Lötvall and Bo Lundbäck

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respirato...

Authors: J. Bousquet, J. Farrell, G. Crooks, P. Hellings, E. H. Bel, M. Bewick, N. H. Chavannes, J. Correia de Sousa, A. A. Cruz, T. Haahtela, G. Joos, N. Khaltaev, J. Malva, A. Muraro, M. Nogues, S. Palkonen…

Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β

The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence...

Authors: Melanie Rae Simpson, Anne Dorthea Bjerkenes Rø, Øystein Grimstad, Roar Johnsen, Ola Storrø and Torbjørn Øien

Optimizing diagnostic tests for persulphate-induced respiratory diseases

Persulphates from hair bleaching products are considered the major cause of occupational-rhinitis and asthma in hairdressers. The specific inhalation challenge (SIC) is considered ‘reference standard’ for diag...

Authors: M. H. Foss-Skiftesvik, L. Winther, H. F. Mosbech, P. S. Skov, M. S. Opstrup, H. Søsted, C. Zachariae, J. D. Johansen and C. R. Johnsen

The impact of the elimination diet on growth and nutrient intake in children with food protein induced gastrointestinal allergies

Non immunoglobulin E (IgE) mediated allergies affecting the gastrointestinal tract require an elimination diet to aid diagnosis. The elimination diet may entail multiple food eliminations that contribute signi...

Authors: Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Gloria Dominguez-Ortega, Adriana Chebar Lozinsky, Ana-Kristina Skrapac, Yara Gholmie, Kate Reeve and Neil Shah

Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review

The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically asses...

Authors: Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela…

Influence of profilin on sensitisation profiles determined by cutaneous tests and IgE to major allergens in polysensitised patients

Profilin sensitisation is considered a diagnostic confounding factor in areas where patients are exposed to multiple pollens. The aim of this study is to assess pollen sensitisation profiles in adults and chil...

Authors: Nieves Segura, Teresa Abos, José A. Compaired, Esther Compés, Isabel Guallar, Manuel Morales, Susana Monzón, José Mozota, Pilar Muñoz, Jesús Pola, Macarena Quintana, Beatriz Rojas, Sara San Juan, Felicitas Villa, Cristina Zapata, Lucía Jimeno…

Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort

Patients often report adverse reactions to wheat. Interpretation of sensitization to wheat pollen and flour with/without sensitization to grass pollen is a clinical problem.

Authors: Carina Venter, Kate Maslin, Syed Hasan Arshad, Veeresh Patil, Jane Grundy, Gillian Glasbey, Roger Twiselton and Taraneh Dean

Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of ne...

Authors: Katrine Lindholm Bøgh, Jolanda van Bilsen, Robert Głogowski, Iván López-Expósito, Grégory Bouchaud, Carine Blanchard, Marie Bodinier, Joost Smit, Raymond Pieters, Shanna Bastiaan-Net, Nicole de Wit, Eva Untersmayr, Karine Adel-Patient, Leon Knippels, Michelle M. Epstein, Mario Noti…

Nutritional adequacy of a cows’ milk exclusion diet in infancy

Infants with suspected cows’ milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of ...

Authors: Kate Maslin, Erin M. Oliver, Karen S. Scally, Josh Atkinson, Keith Foote, Carina Venter, Graham Roberts and Kate E. C. Grimshaw

Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study

Allergen Immunotherapy is a promising treatment of allergy. Seven patients with rhinoconjunctivitis to grass allergen were treated with intralymphatic immunotherapy (ILIT) to explore whether this treatment cou...

Authors: Johannes Martin Schmid, Homaira Nezam, Hans Henrik Torp Madsen, Alexander Schmitz and Hans Jürgen Hoffmann

Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

Breastfeeding has protective effects for the development of allergies and atopy. Recent evidence underlines that consumption of unboiled farm milk in early life is a key factor preventing the development of at...

Authors: Bodo C. Melnik, Swen Malte John, Pedro Carrera-Bastos and Gerd Schmitz

Cow’s milk allergy in Dutch children: an epigenetic pilot survey

Cow’s milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We hav...

Authors: Nicole C. M. Petrus, Peter Henneman, Andrea Venema, Adri Mul, Femke van Sinderen, Martin Haagmans, Olaf Mook, Raoul C. Hennekam, Aline B. Sprikkelman and Marcel Mannens

Dietary intake and risk of asthma in children and adults: protocol for a systematic review and meta-analysis

Diet has been proposed to modulate the risk of asthma in children and adults. An increasing body of epidemiological studies have been published in the last year investigating the association between dietary i...

Authors: Vanessa Garcia-Larsen, Stefano R. Del Giacco, André Moreira, Matteo Bonini, Tari Haahtela, Sergio Bonini, Kai-Håkon Carlsen, Ioana Agache, João Fonseca, Nikolaos G. Papadopoulos and Luís Delgado

Reviewer acknowledgement 2015

Authors: Clive Grattan

Triclosan promotes epicutaneous sensitization to peanut in mice

Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is ...

Authors: Steven Tobar, Leticia Tordesillas and M. Cecilia Berin

Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia

Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy differenc...

Authors: Jyri-Pekka Koskinen, Hannu Kiviranta, Erkki Vartiainen, Pekka Jousilahti, Tiina Vlasoff, Leena von Hertzen, Mika Mäkelä, Tiina Laatikainen and Tari Haahtela

The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test

Basophil activation test (BAT) reproduces IgE-mediated allergic reactions in vitro and has been used as a diagnostic test. Different markers can be used to identify basophils in whole blood and have implicati...

Authors: Alexandra F. Santos, Natalia Bécares, Alick Stephens, Victor Turcanu and Gideon Lack

Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek...

Authors: Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…

Basophil activation test: food challenge in a test tube or specialist research tool?

Oral food challenge (OFC) is the gold-standard to diagnose food allergy; however, it is a labour and resource-intensive procedure with the risk of causing an acute allergic reaction, which is potentially sever...

Authors: Alexandra F. Santos and Gideon Lack

Tolerability of the SQ-standardised grass sublingual immunotherapy tablet in patients treated with concomitant allergy immunotherapy: a non-interventional observational study

The majority of allergic patients are poly-sensitized. For causal treatment by allergy immunotherapy (AIT) a single or few allergen products containing the clinically most relevant allergens are applied, but ...

Authors: Rainer Reiber, Martina Keller, Winfried Keller, Hendrik Wolf, Jörg Schnitker and Eike Wüstenberg

Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?

Cow’s milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called “all...

Authors: Peter Henneman, Nicole C. M. Petrus, Andrea Venema, Femke van Sinderen, Karin van der Lip, Raoul C. Hennekam, Marcel Mannens and Aline B. Sprikkelman

Measurement and interpretation of skin prick test results

There are several methods to read skin prick test results in type-I allergy testing. A commonly used method is to characterize the wheal size by its ‘average diameter’. A more accurate method is to scan the ar...

Authors: J. P. M. van der Valk, R. Gerth van Wijk, E. Hoorn, L. Groenendijk, I. M. Groenendijk and N. W. de Jong