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  1. Content type: Research

    There are several methods to read skin prick test results in type-I allergy testing. A commonly used method is to characterize the wheal size by its ‘average diameter’. A more accurate method is to scan the ar...

    Authors: J. P. M. van der Valk, R. Gerth van Wijk, E. Hoorn, L. Groenendijk, I. M. Groenendijk and N. W. de Jong

    Citation: Clinical and Translational Allergy 2016 6:8

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  2. Content type: Study Protocol

    The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Insect Venom Allergy. We seek to cri...

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A. Akdis, Darío Antolín-Amérigo, M. Beatrice Bilò, Danijela Bokanovic, Moises A. Calderon, Ewa Cichocka-Jarosz, Joanna N. G. Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange…

    Citation: Clinical and Translational Allergy 2016 6:6

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:30

  3. Content type: Study protocol

    The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for Allergic Asthma. We seek to critically assess the effec...

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann…

    Citation: Clinical and Translational Allergy 2016 6:5

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:32

  4. Content type: Research

    The number of injections in the dose escalation of subcutaneous immunotherapy (SCIT) is small for some currently used hypoallergenic allergoids, but can still be inconvenient to patients and can impair compli...

    Authors: A. M. Chaker, B. Al-Kadah, U. Luther, U. Neumann and M. Wagenmann

    Citation: Clinical and Translational Allergy 2016 6:4

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  5. Content type: Research

    The prevalence of food hypersensitivity in the UK is still largely open to debate. Additionally its pathogenesis is also unclear although it is known that there are differing phenotypes. Determining its preval...

    Authors: Kate E. C. Grimshaw, Trevor Bryant, Erin M. Oliver, Jane Martin, Joe Maskell, Terri Kemp, E. N. Clare Mills, Keith D. Foote, Barrie M. Margetts, Kirsten Beyer and Graham Roberts

    Citation: Clinical and Translational Allergy 2016 6:1

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  6. Content type: Research

    The concept of a General Practitioner with Special Interest (GPwSI) was first proposed in the 2000 National Health Service Plan, as a way of providing specialised treatment closer to the patient’s home and red...

    Authors: H. E. Smith, J. Wade and A. J. Frew

    Citation: Clinical and Translational Allergy 2016 6:3

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  7. Content type: Research

    Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce. We explored the role of TS...

    Authors: Christophe P. Frossard, Simone C. Zimmerli, José M. Rincon Garriz and Philippe A. Eigenmann

    Citation: Clinical and Translational Allergy 2016 6:2

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  8. Content type: Review

    Sublingual immunotherapy (SLIT) is an effective and well-tolerated method of treating allergic respiratory diseases associated with seasonal and perennial allergens. In contrast to the subcutaneous route, SLIT...

    Authors: Pascal Demoly, Gianni Passalacqua, Moises A. Calderon and Tarik Yalaoui

    Citation: Clinical and Translational Allergy 2015 5:44

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  9. Content type: Study protocol

    Seasonal Allergic Rhinitis is characterised by inflammation of the nasal mucosa upon exposure to common aeroallergens, affecting up to 20–25 % of the population. For those patients whose symptoms are not contr...

    Authors: Esther Helen Steveling, Mongkol Lao-Araya, Christopher Koulias, Guy Scadding, Aarif Eifan, Louisa K. James, Alina Dumitru, Martin Penagos, Moisés Calderón, Peter Sejer Andersen, Mohamed Shamji and Stephen R. Durham

    Citation: Clinical and Translational Allergy 2015 5:43

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  10. Content type: Research

    Innate immune recognition via Toll-like receptors (TLRs) on barrier cells like epithelial cells has been shown to influence the regulation of local immune responses. Here we determine expression level variatio...

    Authors: J. van Tongeren, K. I. L. Röschmann, S. M. Reinartz, S. Luiten, W. J. Fokkens, E. C. de Jong and C. M. van Drunen

    Citation: Clinical and Translational Allergy 2015 5:42

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  11. Content type: Brief communication

    The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptom...

    Authors: Chiara Nembrini, Anurag Singh, Carlos Antonio De Castro, Annick Mercenier and Sophie Nutten

    Citation: Clinical and Translational Allergy 2015 5:41

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  12. Content type: Brief communication

    Chronic spontaneous urticaria (CSU) poses problems with respect to high prevalence, reduced quality of life, lack of long term efficacy, and expense of current treatments for severe intractable symptoms. There...

    Authors: Karen Lindsay, Josie Goulding, Margot Solomon and Brian Broom

    Citation: Clinical and Translational Allergy 2015 5:40

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  13. Content type: Research

    The affliction of allergic rhinitis (AR) has been trivialised in the past. Recent initiatives by the European Academy of Allergy & Clinical Immunology and by the EU parliament seek to rectify that situation. T...

    Authors: David Price, Glenis Scadding, Dermot Ryan, Claus Bachert, G. Walter Canonica, Joaquim Mullol, Ludger Klimek, Richard Pitman, Sarah Acaster, Ruth Murray and Jean Bousquet

    Citation: Clinical and Translational Allergy 2015 5:39

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  14. Content type: Research

    Montelukast is a leukotriene receptor antagonist. The release of leukotrienes causes narrowing and constricting in the respiratory airways. Blocking the action of these leukotrienes, montelukast can be used fo...

    Authors: Abdel Naser Zaid, Ayman Mousa, Nadia Ghazal and Rana Bustami

    Citation: Clinical and Translational Allergy 2015 5:37

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  15. Content type: Brief communication

    In this observational trial, data were collected on the effectiveness and tolerability/safety of a nasal spray containing tramazoline and essential oils (trade name Rhinospray® Plus) used for symptomatic treatmen...

    Authors: Gábor Katona, Mónika Sultész, Zsolt Farkas, Andrea Gyimesi, Andor Hirschberg, János Huszka, Ferenc Radvánszky, Ákos Simon, Gabriella Fülöp, Júlia Láng, Mária Ablonczy, Günther Nirnberger and Claudia Holm

    Citation: Clinical and Translational Allergy 2015 5:38

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  16. Content type: Research

    The concept of control is gaining importance in the field of allergic rhinitis (AR), with a visual analogue scale (VAS) score being a validated, easy and attractive tool to evaluate AR symptom control. The doc...

    Authors: Peter W. Hellings, Antonella Muraro, Wytske Fokkens, Joaquim Mullol, Claus Bachert, G. Walter Canonica, David Price, Nikos Papadopoulos, Glenis Scadding, Gerd Rasp, Pascal Demoly, Ruth Murray and Jean Bousquet

    Citation: Clinical and Translational Allergy 2015 5:36

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  17. Content type: Brief communication

    The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promo...

    Authors: Philippe Bégin, Janika Schulze, Udo Baron, Sven Olek, Rebecca N. Bauer, Laura Passerini, Rosa Baccheta and Kari C. Nadeau

    Citation: Clinical and Translational Allergy 2015 5:35

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  18. Content type: Review

    Although there is considerable literature pertaining to IgE and non IgE-mediated food allergy, there is a paucity of information on non-immune mediated reactions to foods, other than metabolic disorders such a...

    Authors: Isabel J. Skypala, M. Williams, L. Reeves, R. Meyer and C. Venter

    Citation: Clinical and Translational Allergy 2015 5:34

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  19. Content type: Review

    Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and ...

    Authors: Rohit Saluja, Mahejibin Khan, Martin K. Church and Marcus Maurer

    Citation: Clinical and Translational Allergy 2015 5:33

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  21. Content type: Review

    Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse...

    Authors: Rik Schrijvers, Liesbeth Gilissen, Anca Mirela Chiriac and Pascal Demoly

    Citation: Clinical and Translational Allergy 2015 5:31

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  22. Content type: Review

    Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact ...

    Authors: Marta Ferrer

    Citation: Clinical and Translational Allergy 2015 5:30

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  23. Content type: Study protocol

    Chronic spontaneous urticaria (CSU) formerly known as chronic idiopathic urticaria (CIU) is a severe and distressing skin condition that remains uncontrolled in approximately one half of patients, despite the ...

    Authors: Karsten Weller, Marcus Maurer, Clive Grattan, Alla Nakonechna, Mohamed Abuzakouk, Frédéric Bérard, Gordon Sussman, Ana M. Giménez-Arnau, Javier Ortiz de Frutos, André Knulst, G. Walter Canonica, Kelly Hollis, Doreen McBride and Maria-Magdalena Balp

    Citation: Clinical and Translational Allergy 2015 5:29

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  24. Content type: Brief communication

    Pollen extracts and chemically modified allergoids are used successfully in allergen immunotherapy (AIT). Recombinant extracts offer potential advantages with respect to pharmaceutical quality, standardization...

    Authors: Ludger Klimek, Claus Bachert, Karl-Friedrich Lukat, Oliver Pfaar, Hanns Meyer and Annemie Narkus

    Citation: Clinical and Translational Allergy 2015 5:28

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  25. Content type: Research

    A new subcutaneous specific immunotherapy (SCIT) product adsorbed on aluminium hydroxide has been developed with a short and simplified up-dosing phase, containing a biologically standardized allergen pollen e...

    Authors: Carmen Moreno, Blanca Sáenz De San Pedro, Carmen Millán, Carmen Panizo, Santiago Martín and Fernando Florido

    Citation: Clinical and Translational Allergy 2015 5:27

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  26. Content type: Research

    Sensitization to hazelnut allergens vary depending on the geographic origin and age of the patients. The objective of this study was to further investigate the allergenic activity of hazelnut allergens using s...

    Authors: F. Blanc, H. Bernard, S. Ah-Leung, L. Przybylski-Nicaise, P. Stahl Skov, A. Purohit, F. de Blay, B. Ballmer-Weber, P. Fritsche, M. Fernandez Rivas, I. Reig, A. Sinaniotis, E. Vassilopoulou, K. Hoffmann-Sommergruber, S. Vieths, N. Rigby…

    Citation: Clinical and Translational Allergy 2015 5:26

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  27. Content type: Research

    There is very few data available on the prevalence of food hypersensitivity among adults with asthma. The aim of this study was to explore the prevalence of self-reported adverse reactions and IgE sensitizatio...

    Authors: G. Rentzos, L. Johanson, S. Sjölander, E. Telemo and L. Ekerljung

    Citation: Clinical and Translational Allergy 2015 5:25

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  28. Content type: Review

    Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to ‘cough hypersensiti...

    Authors: Woo-Jung Song and Yoon-Seok Chang

    Citation: Clinical and Translational Allergy 2015 5:24

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  29. Content type: Review

    T helper type 2 (TH2) cells were previously thought to be the main initiating effector cell type in asthma; however, exaggerated TH2 cell activities alone were insufficient to explain all aspects of asthma. Asthm...

    Authors: Leyla Pur Ozyigit, Hideaki Morita and Mubeccel Akdis

    Citation: Clinical and Translational Allergy 2015 5:23

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    The Erratum to this article has been published in Clinical and Translational Allergy 2015 5:32

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Clinical and Translational Allergy

ISSN: 2045-7022

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