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  1. Content type: Research

    The results of studies on the associations of childhood excessive weight/obesity and physical activity with atopic sensitization and atopic diseases are inconsistent. We studied the associations of anthropomet...

    Authors: Kristine Kjer Byberg, Geir Egil Eide, Michele R. Forman, Pétur Benedikt Júlíusson and Knut Øymar

    Citation: Clinical and Translational Allergy 2016 6:33

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  2. Content type: Research

    Patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) report difficulty with sleep.

    Authors: Ana M. Gimenéz-Arnau, Sheldon Spector, Evgeniya Antonova, Benjamin Trzaskoma, Karin Rosén, Theodore A. Omachi, Donald Stull, Maria-Magdalena Balp and Thomas Murphy

    Citation: Clinical and Translational Allergy 2016 6:32

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  3. Content type: Research

    Atopic diseases including asthma, rhinitis and eczema have increased in the second half of the past century. This has been well studied among children and adolescents but with the exception of asthma to a muc...

    Authors: Erik P. Rönmark, Linda Ekerljung, Roxana Mincheva, Sigrid Sjölander, Stig Hagstad, Göran Wennergren, Eva Rönmark, Jan Lötvall and Bo Lundbäck

    Citation: Clinical and Translational Allergy 2016 6:28

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  4. Content type: Review

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respirato...

    Authors: J. Bousquet, J. Farrell, G. Crooks, P. Hellings, E. H. Bel, M. Bewick, N. H. Chavannes, J. Correia de Sousa, A. A. Cruz, T. Haahtela, G. Joos, N. Khaltaev, J. Malva, A. Muraro, M. Nogues, S. Palkonen…

    Citation: Clinical and Translational Allergy 2016 6:29

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:5

  5. Content type: Research

    The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence...

    Authors: Melanie Rae Simpson, Anne Dorthea Bjerkenes Rø, Øystein Grimstad, Roar Johnsen, Ola Storrø and Torbjørn Øien

    Citation: Clinical and Translational Allergy 2016 6:27

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  6. Content type: Research

    Persulphates from hair bleaching products are considered the major cause of occupational-rhinitis and asthma in hairdressers. The specific inhalation challenge (SIC) is considered ‘reference standard’ for diag...

    Authors: M. H. Foss-Skiftesvik, L. Winther, H. F. Mosbech, P. S. Skov, M. S. Opstrup, H. Søsted, C. Zachariae, J. D. Johansen and C. R. Johnsen

    Citation: Clinical and Translational Allergy 2016 6:26

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  7. Content type: Research

    Non immunoglobulin E (IgE) mediated allergies affecting the gastrointestinal tract require an elimination diet to aid diagnosis. The elimination diet may entail multiple food eliminations that contribute signi...

    Authors: Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Gloria Dominguez-Ortega, Adriana Chebar Lozinsky, Ana-Kristina Skrapac, Yara Gholmie, Kate Reeve and Neil Shah

    Citation: Clinical and Translational Allergy 2016 6:25

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  8. Content type: Study protocol

    The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically asses...

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela…

    Citation: Clinical and Translational Allergy 2016 6:24

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:31

  9. Content type: Research

    Profilin sensitisation is considered a diagnostic confounding factor in areas where patients are exposed to multiple pollens. The aim of this study is to assess pollen sensitisation profiles in adults and chil...

    Authors: Nieves Segura, Teresa Abos, José A. Compaired, Esther Compés, Isabel Guallar, Manuel Morales, Susana Monzón, José Mozota, Pilar Muñoz, Jesús Pola, Macarena Quintana, Beatriz Rojas, Sara San Juan, Felicitas Villa, Cristina Zapata, Lucía Jimeno…

    Citation: Clinical and Translational Allergy 2016 6:23

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  10. Content type: Brief communication

    Patients often report adverse reactions to wheat. Interpretation of sensitization to wheat pollen and flour with/without sensitization to grass pollen is a clinical problem.

    Authors: Carina Venter, Kate Maslin, Syed Hasan Arshad, Veeresh Patil, Jane Grundy, Gillian Glasbey, Roger Twiselton and Taraneh Dean

    Citation: Clinical and Translational Allergy 2016 6:22

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  11. Content type: Review

    Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of ne...

    Authors: Katrine Lindholm Bøgh, Jolanda van Bilsen, Robert Głogowski, Iván López-Expósito, Grégory Bouchaud, Carine Blanchard, Marie Bodinier, Joost Smit, Raymond Pieters, Shanna Bastiaan-Net, Nicole de Wit, Eva Untersmayr, Karine Adel-Patient, Leon Knippels, Michelle M. Epstein, Mario Noti…

    Citation: Clinical and Translational Allergy 2016 6:21

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  12. Content type: Brief communication

    Infants with suspected cows’ milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of ...

    Authors: Kate Maslin, Erin M. Oliver, Karen S. Scally, Josh Atkinson, Keith Foote, Carina Venter, Graham Roberts and Kate E. C. Grimshaw

    Citation: Clinical and Translational Allergy 2016 6:20

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  13. Content type: Brief communication

    Allergen Immunotherapy is a promising treatment of allergy. Seven patients with rhinoconjunctivitis to grass allergen were treated with intralymphatic immunotherapy (ILIT) to explore whether this treatment cou...

    Authors: Johannes Martin Schmid, Homaira Nezam, Hans Henrik Torp Madsen, Alexander Schmitz and Hans Jürgen Hoffmann

    Citation: Clinical and Translational Allergy 2016 6:19

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  14. Content type: Review

    Breastfeeding has protective effects for the development of allergies and atopy. Recent evidence underlines that consumption of unboiled farm milk in early life is a key factor preventing the development of at...

    Authors: Bodo C. Melnik, Swen Malte John, Pedro Carrera-Bastos and Gerd Schmitz

    Citation: Clinical and Translational Allergy 2016 6:18

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  15. Content type: Research

    Cow’s milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We hav...

    Authors: Nicole C. M. Petrus, Peter Henneman, Andrea Venema, Adri Mul, Femke van Sinderen, Martin Haagmans, Olaf Mook, Raoul C. Hennekam, Aline B. Sprikkelman and Marcel Mannens

    Citation: Clinical and Translational Allergy 2016 6:16

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  16. Content type: Study protocol

    Diet has been proposed to modulate the risk of asthma in children and adults. An increasing body of epidemiological studies have been published in the last year investigating the association between dietary i...

    Authors: Vanessa Garcia-Larsen, Stefano R. Del Giacco, André Moreira, Matteo Bonini, Tari Haahtela, Sergio Bonini, Kai-Håkon Carlsen, Ioana Agache, João Fonseca, Nikolaos G. Papadopoulos and Luís Delgado

    Citation: Clinical and Translational Allergy 2016 6:17

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  18. Content type: Brief communication

    Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is ...

    Authors: Steven Tobar, Leticia Tordesillas and M. Cecilia Berin

    Citation: Clinical and Translational Allergy 2016 6:13

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  19. Content type: Brief communication

    Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy differenc...

    Authors: Jyri-Pekka Koskinen, Hannu Kiviranta, Erkki Vartiainen, Pekka Jousilahti, Tiina Vlasoff, Leena von Hertzen, Mika Mäkelä, Tiina Laatikainen and Tari Haahtela

    Citation: Clinical and Translational Allergy 2016 6:14

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  20. Content type: Research

    Basophil activation test (BAT) reproduces IgE-mediated allergic reactions in vitro and has been used as a diagnostic test. Different markers can be used to identify basophils in whole blood and have implicati...

    Authors: Alexandra F. Santos, Natalia Bécares, Alick Stephens, Victor Turcanu and Gideon Lack

    Citation: Clinical and Translational Allergy 2016 6:11

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  21. Content type: Study protocol

    The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek...

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…

    Citation: Clinical and Translational Allergy 2016 6:12

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:29

  23. Content type: Research

    The majority of allergic patients are poly-sensitized. For causal treatment by allergy immunotherapy (AIT) a single or few allergen products containing the clinically most relevant allergens are applied, but ...

    Authors: Rainer Reiber, Martina Keller, Winfried Keller, Hendrik Wolf, Jörg Schnitker and Eike Wüstenberg

    Citation: Clinical and Translational Allergy 2016 6:9

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  24. Content type: Research

    Cow’s milk allergy (CMA) is the most common allergic disease in infancy. It is not clear, whether infants with CMA have an increased risk of developing other allergic diseases later in life, the so-called “all...

    Authors: Peter Henneman, Nicole C. M. Petrus, Andrea Venema, Femke van Sinderen, Karin van der Lip, Raoul C. Hennekam, Marcel Mannens and Aline B. Sprikkelman

    Citation: Clinical and Translational Allergy 2016 6:7

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  25. Content type: Research

    There are several methods to read skin prick test results in type-I allergy testing. A commonly used method is to characterize the wheal size by its ‘average diameter’. A more accurate method is to scan the ar...

    Authors: J. P. M. van der Valk, R. Gerth van Wijk, E. Hoorn, L. Groenendijk, I. M. Groenendijk and N. W. de Jong

    Citation: Clinical and Translational Allergy 2016 6:8

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  26. Content type: Study Protocol

    The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Insect Venom Allergy. We seek to cri...

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A. Akdis, Darío Antolín-Amérigo, M. Beatrice Bilò, Danijela Bokanovic, Moises A. Calderon, Ewa Cichocka-Jarosz, Joanna N. G. Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange…

    Citation: Clinical and Translational Allergy 2016 6:6

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:30

  27. Content type: Study protocol

    The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for Allergic Asthma. We seek to critically assess the effec...

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann…

    Citation: Clinical and Translational Allergy 2016 6:5

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    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:32

  28. Content type: Research

    The number of injections in the dose escalation of subcutaneous immunotherapy (SCIT) is small for some currently used hypoallergenic allergoids, but can still be inconvenient to patients and can impair compli...

    Authors: A. M. Chaker, B. Al-Kadah, U. Luther, U. Neumann and M. Wagenmann

    Citation: Clinical and Translational Allergy 2016 6:4

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  29. Content type: Research

    The prevalence of food hypersensitivity in the UK is still largely open to debate. Additionally its pathogenesis is also unclear although it is known that there are differing phenotypes. Determining its preval...

    Authors: Kate E. C. Grimshaw, Trevor Bryant, Erin M. Oliver, Jane Martin, Joe Maskell, Terri Kemp, E. N. Clare Mills, Keith D. Foote, Barrie M. Margetts, Kirsten Beyer and Graham Roberts

    Citation: Clinical and Translational Allergy 2016 6:1

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  30. Content type: Research

    The concept of a General Practitioner with Special Interest (GPwSI) was first proposed in the 2000 National Health Service Plan, as a way of providing specialised treatment closer to the patient’s home and red...

    Authors: H. E. Smith, J. Wade and A. J. Frew

    Citation: Clinical and Translational Allergy 2016 6:3

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  31. Content type: Research

    Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce. We explored the role of TS...

    Authors: Christophe P. Frossard, Simone C. Zimmerli, José M. Rincon Garriz and Philippe A. Eigenmann

    Citation: Clinical and Translational Allergy 2016 6:2

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  32. Content type: Review

    Sublingual immunotherapy (SLIT) is an effective and well-tolerated method of treating allergic respiratory diseases associated with seasonal and perennial allergens. In contrast to the subcutaneous route, SLIT...

    Authors: Pascal Demoly, Gianni Passalacqua, Moises A. Calderon and Tarik Yalaoui

    Citation: Clinical and Translational Allergy 2015 5:44

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  33. Content type: Study protocol

    Seasonal Allergic Rhinitis is characterised by inflammation of the nasal mucosa upon exposure to common aeroallergens, affecting up to 20–25 % of the population. For those patients whose symptoms are not contr...

    Authors: Esther Helen Steveling, Mongkol Lao-Araya, Christopher Koulias, Guy Scadding, Aarif Eifan, Louisa K. James, Alina Dumitru, Martin Penagos, Moisés Calderón, Peter Sejer Andersen, Mohamed Shamji and Stephen R. Durham

    Citation: Clinical and Translational Allergy 2015 5:43

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  34. Content type: Research

    Innate immune recognition via Toll-like receptors (TLRs) on barrier cells like epithelial cells has been shown to influence the regulation of local immune responses. Here we determine expression level variatio...

    Authors: J. van Tongeren, K. I. L. Röschmann, S. M. Reinartz, S. Luiten, W. J. Fokkens, E. C. de Jong and C. M. van Drunen

    Citation: Clinical and Translational Allergy 2015 5:42

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  35. Content type: Brief communication

    The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptom...

    Authors: Chiara Nembrini, Anurag Singh, Carlos Antonio De Castro, Annick Mercenier and Sophie Nutten

    Citation: Clinical and Translational Allergy 2015 5:41

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  36. Content type: Brief communication

    Chronic spontaneous urticaria (CSU) poses problems with respect to high prevalence, reduced quality of life, lack of long term efficacy, and expense of current treatments for severe intractable symptoms. There...

    Authors: Karen Lindsay, Josie Goulding, Margot Solomon and Brian Broom

    Citation: Clinical and Translational Allergy 2015 5:40

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  37. Content type: Research

    The affliction of allergic rhinitis (AR) has been trivialised in the past. Recent initiatives by the European Academy of Allergy & Clinical Immunology and by the EU parliament seek to rectify that situation. T...

    Authors: David Price, Glenis Scadding, Dermot Ryan, Claus Bachert, G. Walter Canonica, Joaquim Mullol, Ludger Klimek, Richard Pitman, Sarah Acaster, Ruth Murray and Jean Bousquet

    Citation: Clinical and Translational Allergy 2015 5:39

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  38. Content type: Research

    Montelukast is a leukotriene receptor antagonist. The release of leukotrienes causes narrowing and constricting in the respiratory airways. Blocking the action of these leukotrienes, montelukast can be used fo...

    Authors: Abdel Naser Zaid, Ayman Mousa, Nadia Ghazal and Rana Bustami

    Citation: Clinical and Translational Allergy 2015 5:37

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  39. Content type: Brief communication

    In this observational trial, data were collected on the effectiveness and tolerability/safety of a nasal spray containing tramazoline and essential oils (trade name Rhinospray® Plus) used for symptomatic treatmen...

    Authors: Gábor Katona, Mónika Sultész, Zsolt Farkas, Andrea Gyimesi, Andor Hirschberg, János Huszka, Ferenc Radvánszky, Ákos Simon, Gabriella Fülöp, Júlia Láng, Mária Ablonczy, Günther Nirnberger and Claudia Holm

    Citation: Clinical and Translational Allergy 2015 5:38

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  40. Content type: Research

    The concept of control is gaining importance in the field of allergic rhinitis (AR), with a visual analogue scale (VAS) score being a validated, easy and attractive tool to evaluate AR symptom control. The doc...

    Authors: Peter W. Hellings, Antonella Muraro, Wytske Fokkens, Joaquim Mullol, Claus Bachert, G. Walter Canonica, David Price, Nikos Papadopoulos, Glenis Scadding, Gerd Rasp, Pascal Demoly, Ruth Murray and Jean Bousquet

    Citation: Clinical and Translational Allergy 2015 5:36

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  41. Content type: Brief communication

    The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promo...

    Authors: Philippe Bégin, Janika Schulze, Udo Baron, Sven Olek, Rebecca N. Bauer, Laura Passerini, Rosa Baccheta and Kari C. Nadeau

    Citation: Clinical and Translational Allergy 2015 5:35

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  42. Content type: Review

    Although there is considerable literature pertaining to IgE and non IgE-mediated food allergy, there is a paucity of information on non-immune mediated reactions to foods, other than metabolic disorders such a...

    Authors: Isabel J. Skypala, M. Williams, L. Reeves, R. Meyer and C. Venter

    Citation: Clinical and Translational Allergy 2015 5:34

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  43. Content type: Review

    Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and ...

    Authors: Rohit Saluja, Mahejibin Khan, Martin K. Church and Marcus Maurer

    Citation: Clinical and Translational Allergy 2015 5:33

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  45. Content type: Review

    Drug hypersensitivity reactions (DHR) have been present since the advent of drugs. In particular T-cell mediated delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse...

    Authors: Rik Schrijvers, Liesbeth Gilissen, Anca Mirela Chiriac and Pascal Demoly

    Citation: Clinical and Translational Allergy 2015 5:31

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  46. Content type: Review

    Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact ...

    Authors: Marta Ferrer

    Citation: Clinical and Translational Allergy 2015 5:30

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  47. Content type: Study protocol

    Chronic spontaneous urticaria (CSU) formerly known as chronic idiopathic urticaria (CIU) is a severe and distressing skin condition that remains uncontrolled in approximately one half of patients, despite the ...

    Authors: Karsten Weller, Marcus Maurer, Clive Grattan, Alla Nakonechna, Mohamed Abuzakouk, Frédéric Bérard, Gordon Sussman, Ana M. Giménez-Arnau, Javier Ortiz de Frutos, André Knulst, G. Walter Canonica, Kelly Hollis, Doreen McBride and Maria-Magdalena Balp

    Citation: Clinical and Translational Allergy 2015 5:29

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  48. Content type: Brief communication

    Pollen extracts and chemically modified allergoids are used successfully in allergen immunotherapy (AIT). Recombinant extracts offer potential advantages with respect to pharmaceutical quality, standardization...

    Authors: Ludger Klimek, Claus Bachert, Karl-Friedrich Lukat, Oliver Pfaar, Hanns Meyer and Annemie Narkus

    Citation: Clinical and Translational Allergy 2015 5:28

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  49. Content type: Research

    A new subcutaneous specific immunotherapy (SCIT) product adsorbed on aluminium hydroxide has been developed with a short and simplified up-dosing phase, containing a biologically standardized allergen pollen e...

    Authors: Carmen Moreno, Blanca Sáenz De San Pedro, Carmen Millán, Carmen Panizo, Santiago Martín and Fernando Florido

    Citation: Clinical and Translational Allergy 2015 5:27

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  50. Content type: Research

    Sensitization to hazelnut allergens vary depending on the geographic origin and age of the patients. The objective of this study was to further investigate the allergenic activity of hazelnut allergens using s...

    Authors: F. Blanc, H. Bernard, S. Ah-Leung, L. Przybylski-Nicaise, P. Stahl Skov, A. Purohit, F. de Blay, B. Ballmer-Weber, P. Fritsche, M. Fernandez Rivas, I. Reig, A. Sinaniotis, E. Vassilopoulou, K. Hoffmann-Sommergruber, S. Vieths, N. Rigby…

    Citation: Clinical and Translational Allergy 2015 5:26

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Clinical and Translational Allergy

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