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  1. The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity...

    Authors: Esben Eller, Antonella Muraro, Ronald Dahl, Charlotte Gotthard Mortz and Carsten Bindslev-Jensen
    Citation: Clinical and Translational Allergy 2018 8:29
    Content type: Research Published on:

  2. Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE pla...

    Authors: Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun and Kunmei Ji
    Citation: Clinical and Translational Allergy 2018 8:27
    Content type: Review Published on:

  3. Allergic rhinitis (AR) is a highly prevalent disease that generates high social and health care costs and also has a significant effect on quality of life and quality of sleep. It has also been related to some...

    Authors: R. Muñoz-Cano, P. Ribó, G. Araujo, E. Giralt, J. Sanchez-Lopez and A. Valero
    Citation: Clinical and Translational Allergy 2018 8:23
    Content type: Research Published on:

  4. Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctiva...

    Authors: Janina Köther, Alicia Mandl, Silke Allekotte, Anatoli Astvatsatourov, Janin Chwieralski, Jan-Patrick Liedtke, Ursula Pieper-Fürst, Esther Raskopf, Kija Shah-Hosseini and Ralph Mösges
    Citation: Clinical and Translational Allergy 2018 8:28
    Content type: Research Published on:

  5. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy...

    Authors: Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang and Yueqi Sun
    Citation: Clinical and Translational Allergy 2018 8:24
    Content type: Research Published on:

  9. The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countrie...

    Authors: Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská and Marek Malý
    Citation: Clinical and Translational Allergy 2018 8:19
    Content type: Research Published on:

  10. The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resultin...

    Authors: Maria D’Amato, Antonio Molino, Giovanna Calabrese, Lorenzo Cecchi, Isabella Annesi-Maesano and Gennaro D’Amato
    Citation: Clinical and Translational Allergy 2018 8:20
    Content type: Review Published on:

  11. The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. Th...

    Authors: Bertine M. J. Flokstra-de Blok, Thecla M. Brakel, Marian Wubs, Ben Skidmore, Janwillem W. H. Kocks, Joanne N. G. Oude Elberink, Marie-Louise A. Schuttelaar, Jantina L. van der Velde, Thys van der Molen and Anthony E. J. Dubois
    Citation: Clinical and Translational Allergy 2018 8:18
    Content type: Research Published on:

  12. Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between...

    Authors: Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A. Camargo Jr, Mübeccel Akdis, Cezmi A. Akdis…
    Citation: Clinical and Translational Allergy 2018 8:22
    Content type: Research Published on:

  13. Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often se...

    Authors: I. Doña, J. C. Caubet, K. Brockow, M. Doyle, E. Moreno, I. Terreehorst and M. J. Torres
    Citation: Clinical and Translational Allergy 2018 8:16
    Content type: Review Published on:

  14. Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five...

    Authors: Rita Amaral, João A. Fonseca, Tiago Jacinto, Ana M. Pereira, Andrei Malinovschi, Christer Janson and Kjell Alving
    Citation: Clinical and Translational Allergy 2018 8:13
    Content type: Research Published on:

  16. House dust mites are small arthropods that produce proteins—found in their feces, body parts, and eggs—that are major triggers of human allergies worldwide. The goal of this review is to describe the current m...

    Authors: Yubao Cui, Qiong Wang and Haoyuan Jia
    Citation: Clinical and Translational Allergy 2018 8:14
    Content type: Review Published on:

  17. The pathogenesis of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is not fully understood. Our previous study reported that chemokine CCL27 was overexpressed in serum of SJS/TEN patients. The...

    Authors: Fang Wang, Yanting Ye, Ze-Yu Luo, Qian Gao, Di-Qing Luo and Xingqi Zhang
    Citation: Clinical and Translational Allergy 2018 8:12
    Content type: Research Published on:

  18. The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A...

    Authors: Helen Neighbour, Mena Soliman, Lisa M. Steacy, Pascal Hickey, Beth Forbes, Mark Larché and Anne K. Ellis
    Citation: Clinical and Translational Allergy 2018 8:15
    Content type: Research Published on:

  19. Ambient air quality monitoring is a governmental duty that is widely carried out in order to detect non-biological (“chemical”) components in ambient air, such as particles of < 10 µm (PM10, PM2.5), ozone, sulphu...

    Authors: J. T. M. Buters, C. Antunes, A. Galveias, K. C. Bergmann, M. Thibaudon, C. Galán, C. Schmidt-Weber and J. Oteros
    Citation: Clinical and Translational Allergy 2018 8:9
    Content type: Brief communication Published on:

  20. Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the ...

    Authors: Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie and Stella Cochrane
    Citation: Clinical and Translational Allergy 2018 8:10
    Content type: Research Published on:

  21. Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of b...

    Authors: Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J. Longhurst, Laurence Bouillet and Irmgard Andresen
    Citation: Clinical and Translational Allergy 2018 8:11
    Content type: Research Published on:

  23. Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persisten...

    Authors: Paulo Camargos, Alessandra Affonso, Geralda Calazans, Lidiana Ramalho, Marisa L. Ribeiro, Nulma Jentzsch, Simone Senna and Renato T. Stein
    Citation: Clinical and Translational Allergy 2018 8:7
    Content type: Research Published on:

  24. We performed a MeSH term-based bibliometric analysis aiming to assess the publication trends of EAACI journals, namely Allergy, Pediatric Allergy and Immunology (PAI) (from 1990 to 2015) and Clinical and Trans...

    Authors: Daniel Martinho-Dias, Bernardo Sousa-Pinto, Júlio Botelho-Souza, António Soares, Luís Delgado and João Almeida Fonseca
    Citation: Clinical and Translational Allergy 2018 8:6
    Content type: Letter to the Editor Published on:

  25. Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways....

    Authors: Wei Tang, Steven G. Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M. Salter, Gail M. Gauvreau, Paul M. O’Byrne and Roma Sehmi
    Citation: Clinical and Translational Allergy 2018 8:5
    Content type: Research Published on:

  26. Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various pra...

    Authors: Marjolein Vandekerckhove, Bart Van Droogenbroeck, Marc De Loose, Katleen Coudijzer, Marc Coppens, Philippe Gevaert and Hilde Lapeere
    Citation: Clinical and Translational Allergy 2018 8:3
    Content type: Research Published on:

  27. In the original version of this article [1], published on 23 August 2017, an incorrect version of Additional file 4 has been used. The corrected version of Additional file 4 is given in this correction.

    Authors: Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M. Fleischer, Ralf G. Heine, Michael Levin, Mario C. Vieira and Adam T. Fox
    Citation: Clinical and Translational Allergy 2018 8:4
    Content type: Correction Published on:

    The original article was published in Clinical and Translational Allergy 2017 7:26

  28. Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents...

    Authors: Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Osvaldo Correia and Luís Delgado
    Citation: Clinical and Translational Allergy 2018 8:2
    Content type: Research Published on:

  29. European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to dete...

    Authors: Maja A. Hofmann, Ana Giménez-Arnau, Werner Aberer, Carsten Bindslev-Jensen and Torsten Zuberbier
    Citation: Clinical and Translational Allergy 2018 8:1
    Content type: Brief communication Published on:

  30. On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. ...

    Authors: Peter W. Hellings, David Borrelli, Sirpa Pietikainen, Ioana Agache, Cezmi Akdis, Claus Bachert, Michael Bewick, Erna Botjes, Jannis Constantinidis, Wytske Fokkens, Tari Haahtela, Claire Hopkins, Maddalena Illario, Guy Joos, Valerie Lund, Antonella Muraro…
    Citation: Clinical and Translational Allergy 2017 7:49
    Content type: Review Published on:

  31. In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) ...

    Authors: Mônica Versiani Nunes Pinheiro de Queiroz, Cristina Gonçalves Alvim, Álvaro A. Cruz and Laura Maria de Lima Belizário Facury Lasmar
    Citation: Clinical and Translational Allergy 2017 7:48
    Content type: Research Published on:

  33. Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different com...

    Authors: Alberto Alvarez-Perea, Luciana Kase Tanno and María L. Baeza
    Citation: Clinical and Translational Allergy 2017 7:45
    Content type: Review Published on:

  34. Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and...

    Authors: M. Fröhlich, M. Pinart, T. Keller, A. Reich, B. Cabieses, C. Hohmann, D. S. Postma, J. Bousquet, J. M. Antó, T. Keil and S. Roll
    Citation: Clinical and Translational Allergy 2017 7:44
    Content type: Review Published on:

  35. The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

    Authors: Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W. Hellings and Ioana Agache
    Citation: Clinical and Translational Allergy 2017 7:46
    Content type: Review Published on:

  36. Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was t...

    Authors: Andrzej Bożek, Krzysztof Kołodziejczyk, Renata Kozłowska and Giorgio Walter Canonica
    Citation: Clinical and Translational Allergy 2017 7:43
    Content type: Research Published on:

  37. Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an im...

    Authors: Yumei Liu, Jianglong Peng, Ying Zhou and Yubao Cui
    Citation: Clinical and Translational Allergy 2017 7:41
    Content type: Review Published on:

  38. The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storag...

    Authors: Mark A. Blankestijn, André C. Knulst, Edward F. Knol, Thuy-My Le, Heike Rockmann, Henny G. Otten and Rob J. B. Klemans
    Citation: Clinical and Translational Allergy 2017 7:42
    Content type: Research Published on:

  39. Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may...

    Authors: Line K. Tannert, Sidsel Falkencrone, Charlotte G. Mortz, Carsten Bindslev-Jensen and Per Stahl Skov
    Citation: Clinical and Translational Allergy 2017 7:40
    Content type: Research Published on:

  40. Adherence to medication is crucial for achieving treatment control in chronic obstructive lung diseases. This study refers to the “necessity-concerns framework” and examines the associations between beliefs a...

    Authors: Susanne Brandstetter, Tamara Finger, Wiebke Fischer, Magdalena Brandl, Merle Böhmer, Michael Pfeifer and Christian Apfelbacher
    Citation: Clinical and Translational Allergy 2017 7:39
    Content type: Brief communication Published on:

  41. The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local aller...

    Authors: Cristoforo Incorvaia, Nicola Fuiano, Irene Martignago, Bruna L. Gritti and Erminia Ridolo
    Citation: Clinical and Translational Allergy 2017 7:38
    Content type: Editorial Published on:

  42. A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, i...

    Authors: J. Bousquet, G. L. Onorato, C. Bachert, M. Barbolini, A. Bedbrook, L. Bjermer, J. Correia de Sousa, N. H. Chavannes, A. A. Cruz, E. De Manuel Keenoy, P. Devillier, J. Fonseca, S. Hun, T. Kostka, P. W. Hellings, M. Illario…
    Citation: Clinical and Translational Allergy 2017 7:37
    Content type: Review Published on:

  43. Hereditary angioedema (HAE) is characterized by recurrent attacks of subcutaneous or submucosal edema. Attacks are unpredictable, debilitating, and have a significant impact on quality of life. Patients may be...

    Authors: Marc A. Riedl, Jonathan A. Bernstein, Timothy Craig, Aleena Banerji, Markus Magerl, Marco Cicardi, Hilary J. Longhurst, Mustafa M. Shennak, William H. Yang, Jennifer Schranz, Jovanna Baptista and Paula J. Busse
    Citation: Clinical and Translational Allergy 2017 7:36
    Content type: Study protocol Published on:

  44. Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow’s milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety.

    Authors: Marlotte M. Vonk, Laura Wagenaar, Raymond H. H. Pieters, Leon M. J. Knippels, Linette E. M. Willemsen, Joost J. Smit, Betty C. A. M. van Esch and Johan Garssen
    Citation: Clinical and Translational Allergy 2017 7:35
    Content type: Research Published on:

  45. General Practitioners suffer from guideline fatigue. They come fast and furious in many complicated forms. Cow’s milk allergy (CMA) is one of the most common presentations of food allergy seen in early childho...

    Authors: Paul Netts and Louise J. Michaelis
    Citation: Clinical and Translational Allergy 2017 7:34
    Content type: Editorial Published on:

    The Review to this article has been published in Clinical and Translational Allergy 2017 7:26

  46. The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used...

    Authors: Georg Boelke, Uwe Berger, Karl-Christian Bergmann, Carsten Bindslev-Jensen, Jean Bousquet, Julia Gildemeister, Marek Jutel, Oliver Pfaar, Torsten Sehlinger and Torsten Zuberbier
    Citation: Clinical and Translational Allergy 2017 7:33
    Content type: Research Published on:

  47. Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann…
    Citation: Clinical and Translational Allergy 2017 7:32
    Content type: Erratum Published on:

    The original article was published in Clinical and Translational Allergy 2016 6:5

  48. Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela…
    Citation: Clinical and Translational Allergy 2017 7:31
    Content type: Erratum Published on:

    The original article was published in Clinical and Translational Allergy 2016 6:24

  49. Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A. Akdis, Darío Antolín-Amérigo, M. Beatrice Bilò, Danijela Bokanovic, Moises A. Calderon, Ewa Cichocka-Jarosz, Joanna N. G. Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange…
    Citation: Clinical and Translational Allergy 2017 7:30
    Content type: Erratum Published on:

    The original article was published in Clinical and Translational Allergy 2016 6:6

  50. Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…
    Citation: Clinical and Translational Allergy 2017 7:29
    Content type: Erratum Published on:

    The original article was published in Clinical and Translational Allergy 2016 6:12

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