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  1. Content type: Research

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy...

    Authors: Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang and Yueqi Sun

    Citation: Clinical and Translational Allergy 2018 8:24

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  2. Content type: Research

    The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countrie...

    Authors: Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská and Marek Malý

    Citation: Clinical and Translational Allergy 2018 8:19

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  3. Content type: Review

    The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resultin...

    Authors: Maria D’Amato, Antonio Molino, Giovanna Calabrese, Lorenzo Cecchi, Isabella Annesi-Maesano and Gennaro D’Amato

    Citation: Clinical and Translational Allergy 2018 8:20

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  4. Content type: Research

    The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. Th...

    Authors: Bertine M. J. Flokstra-de Blok, Thecla M. Brakel, Marian Wubs, Ben Skidmore, Janwillem W. H. Kocks, Joanne N. G. Oude Elberink, Marie-Louise A. Schuttelaar, Jantina L. van der Velde, Thys van der Molen and Anthony E. J. Dubois

    Citation: Clinical and Translational Allergy 2018 8:18

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  5. Content type: Research

    Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between...

    Authors: Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A. Camargo Jr, Mübeccel Akdis, Cezmi A. Akdis…

    Citation: Clinical and Translational Allergy 2018 8:22

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  6. Content type: Review

    Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated (allergy) or non-immunologically mediated. The high number of DHRs that are unconfirmed and often se...

    Authors: I. Doña, J. C. Caubet, K. Brockow, M. Doyle, E. Moreno, I. Terreehorst and M. J. Torres

    Citation: Clinical and Translational Allergy 2018 8:16

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  7. Content type: Research

    Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five...

    Authors: Rita Amaral, João A. Fonseca, Tiago Jacinto, Ana M. Pereira, Andrei Malinovschi, Christer Janson and Kjell Alving

    Citation: Clinical and Translational Allergy 2018 8:13

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  8. Content type: Review

    House dust mites are small arthropods that produce proteins—found in their feces, body parts, and eggs—that are major triggers of human allergies worldwide. The goal of this review is to describe the current m...

    Authors: Yubao Cui, Qiong Wang and Haoyuan Jia

    Citation: Clinical and Translational Allergy 2018 8:14

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  9. Content type: Research

    The pathogenesis of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is not fully understood. Our previous study reported that chemokine CCL27 was overexpressed in serum of SJS/TEN patients. The...

    Authors: Fang Wang, Yanting Ye, Ze-Yu Luo, Qian Gao, Di-Qing Luo and Xingqi Zhang

    Citation: Clinical and Translational Allergy 2018 8:12

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  10. Content type: Research

    The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A...

    Authors: Helen Neighbour, Mena Soliman, Lisa M. Steacy, Pascal Hickey, Beth Forbes, Mark Larché and Anne K. Ellis

    Citation: Clinical and Translational Allergy 2018 8:15

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  11. Content type: Brief communication

    Ambient air quality monitoring is a governmental duty that is widely carried out in order to detect non-biological (“chemical”) components in ambient air, such as particles of < 10 µm (PM10, PM2.5), ozone, sulphu...

    Authors: J. T. M. Buters, C. Antunes, A. Galveias, K. C. Bergmann, M. Thibaudon, C. Galán, C. Schmidt-Weber and J. Oteros

    Citation: Clinical and Translational Allergy 2018 8:9

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  12. Content type: Research

    Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the ...

    Authors: Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie and Stella Cochrane

    Citation: Clinical and Translational Allergy 2018 8:10

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  13. Content type: Research

    Icatibant is a bradykinin B2-receptor antagonist used for the treatment of hereditary angioedema attacks resulting from C1-inhibitor deficiency. Treatment is not adjusted by body weight however the impact of b...

    Authors: Teresa Caballero, Andrea Zanichelli, Werner Aberer, Marcus Maurer, Hilary J. Longhurst, Laurence Bouillet and Irmgard Andresen

    Citation: Clinical and Translational Allergy 2018 8:11

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  14. Content type: Research

    Daily inhaled corticosteroids are widely recommended for mild persistent asthma. This study aimed to assess the efficacy of the intermittent use of beclomethasone as an alternative treatment for mild persisten...

    Authors: Paulo Camargos, Alessandra Affonso, Geralda Calazans, Lidiana Ramalho, Marisa L. Ribeiro, Nulma Jentzsch, Simone Senna and Renato T. Stein

    Citation: Clinical and Translational Allergy 2018 8:7

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  15. Content type: Letter to the Editor

    We performed a MeSH term-based bibliometric analysis aiming to assess the publication trends of EAACI journals, namely Allergy, Pediatric Allergy and Immunology (PAI) (from 1990 to 2015) and Clinical and Trans...

    Authors: Daniel Martinho-Dias, Bernardo Sousa-Pinto, Júlio Botelho-Souza, António Soares, Luís Delgado and João Almeida Fonseca

    Citation: Clinical and Translational Allergy 2018 8:6

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  16. Content type: Research

    Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways....

    Authors: Wei Tang, Steven G. Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M. Salter, Gail M. Gauvreau, Paul M. O’Byrne and Roma Sehmi

    Citation: Clinical and Translational Allergy 2018 8:5

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  17. Content type: Research

    Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various pra...

    Authors: Marjolein Vandekerckhove, Bart Van Droogenbroeck, Marc De Loose, Katleen Coudijzer, Marc Coppens, Philippe Gevaert and Hilde Lapeere

    Citation: Clinical and Translational Allergy 2018 8:3

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  18. Content type: Correction

    In the original version of this article [1], published on 23 August 2017, an incorrect version of Additional file 4 has been used. The corrected version of Additional file 4 is given in this correction.

    Authors: Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M. Fleischer, Ralf G. Heine, Michael Levin, Mario C. Vieira and Adam T. Fox

    Citation: Clinical and Translational Allergy 2018 8:4

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    The original article was published in Clinical and Translational Allergy 2017 7:26

  19. Content type: Research

    Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents...

    Authors: Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Osvaldo Correia and Luís Delgado

    Citation: Clinical and Translational Allergy 2018 8:2

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  20. Content type: Brief communication

    European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to dete...

    Authors: Maja A. Hofmann, Ana Giménez-Arnau, Werner Aberer, Carsten Bindslev-Jensen and Torsten Zuberbier

    Citation: Clinical and Translational Allergy 2018 8:1

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  21. Content type: Review

    On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. ...

    Authors: Peter W. Hellings, David Borrelli, Sirpa Pietikainen, Ioana Agache, Cezmi Akdis, Claus Bachert, Michael Bewick, Erna Botjes, Jannis Constantinidis, Wytske Fokkens, Tari Haahtela, Claire Hopkins, Maddalena Illario, Guy Joos, Valerie Lund, Antonella Muraro…

    Citation: Clinical and Translational Allergy 2017 7:49

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  22. Content type: Research

    In severe asthma, high doses of inhaled corticosteroids (ICS) are used in order to achieve clinical and functional control. This study aimed to evaluate lung function in outpatients (children and adolescents) ...

    Authors: Mônica Versiani Nunes Pinheiro de Queiroz, Cristina Gonçalves Alvim, Álvaro A. Cruz and Laura Maria de Lima Belizário Facury Lasmar

    Citation: Clinical and Translational Allergy 2017 7:48

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  23. Content type: Review

    Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems. It presents with very different com...

    Authors: Alberto Alvarez-Perea, Luciana Kase Tanno and María L. Baeza

    Citation: Clinical and Translational Allergy 2017 7:45

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  24. Content type: Review

    Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and...

    Authors: M. Fröhlich, M. Pinart, T. Keller, A. Reich, B. Cabieses, C. Hohmann, D. S. Postma, J. Bousquet, J. M. Antó, T. Keil and S. Roll

    Citation: Clinical and Translational Allergy 2017 7:44

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  25. Content type: Review

    The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to supp...

    Authors: Jean Bousquet, Clive Grattan, Thomas Bieber, Paolo Matricardi, Hans Uwe Simon, Ulrich Wahn, Antonella Muraro, Peter W. Hellings and Ioana Agache

    Citation: Clinical and Translational Allergy 2017 7:46

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  26. Content type: Research

    Allergen specific immunotherapy (AIT) in elderly patients is controversial, and there is still little evidence supporting the safety and efficacy of this treatment in this population. The study objective was t...

    Authors: Andrzej Bożek, Krzysztof Kołodziejczyk, Renata Kozłowska and Giorgio Walter Canonica

    Citation: Clinical and Translational Allergy 2017 7:43

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  27. Content type: Review

    Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an im...

    Authors: Yumei Liu, Jianglong Peng, Ying Zhou and Yubao Cui

    Citation: Clinical and Translational Allergy 2017 7:41

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  28. Content type: Research

    The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storag...

    Authors: Mark A. Blankestijn, André C. Knulst, Edward F. Knol, Thuy-My Le, Heike Rockmann, Henny G. Otten and Rob J. B. Klemans

    Citation: Clinical and Translational Allergy 2017 7:42

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  29. Content type: Research

    Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may...

    Authors: Line K. Tannert, Sidsel Falkencrone, Charlotte G. Mortz, Carsten Bindslev-Jensen and Per Stahl Skov

    Citation: Clinical and Translational Allergy 2017 7:40

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  30. Content type: Brief communication

    Adherence to medication is crucial for achieving treatment control in chronic obstructive lung diseases. This study refers to the “necessity-concerns framework” and examines the associations between beliefs a...

    Authors: Susanne Brandstetter, Tamara Finger, Wiebke Fischer, Magdalena Brandl, Merle Böhmer, Michael Pfeifer and Christian Apfelbacher

    Citation: Clinical and Translational Allergy 2017 7:39

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  31. Content type: Editorial

    The discovery of an exclusive local production of IgE antibodies dates back to the 1970s, but only recently the pathophysiology of such phenomenon was deeply investigated, leading to the concept of local aller...

    Authors: Cristoforo Incorvaia, Nicola Fuiano, Irene Martignago, Bruna L. Gritti and Erminia Ridolo

    Citation: Clinical and Translational Allergy 2017 7:38

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  32. Content type: Review

    A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, i...

    Authors: J. Bousquet, G. L. Onorato, C. Bachert, M. Barbolini, A. Bedbrook, L. Bjermer, J. Correia de Sousa, N. H. Chavannes, A. A. Cruz, E. De Manuel Keenoy, P. Devillier, J. Fonseca, S. Hun, T. Kostka, P. W. Hellings, M. Illario…

    Citation: Clinical and Translational Allergy 2017 7:37

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  33. Content type: Study protocol

    Hereditary angioedema (HAE) is characterized by recurrent attacks of subcutaneous or submucosal edema. Attacks are unpredictable, debilitating, and have a significant impact on quality of life. Patients may be...

    Authors: Marc A. Riedl, Jonathan A. Bernstein, Timothy Craig, Aleena Banerji, Markus Magerl, Marco Cicardi, Hilary J. Longhurst, Mustafa M. Shennak, William H. Yang, Jennifer Schranz, Jovanna Baptista and Paula J. Busse

    Citation: Clinical and Translational Allergy 2017 7:36

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  34. Content type: Research

    Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow’s milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety.

    Authors: Marlotte M. Vonk, Laura Wagenaar, Raymond H. H. Pieters, Leon M. J. Knippels, Linette E. M. Willemsen, Joost J. Smit, Betty C. A. M. van Esch and Johan Garssen

    Citation: Clinical and Translational Allergy 2017 7:35

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  35. Content type: Editorial

    General Practitioners suffer from guideline fatigue. They come fast and furious in many complicated forms. Cow’s milk allergy (CMA) is one of the most common presentations of food allergy seen in early childho...

    Authors: Paul Netts and Louise J. Michaelis

    Citation: Clinical and Translational Allergy 2017 7:34

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    The Review to this article has been published in Clinical and Translational Allergy 2017 7:26

  36. Content type: Research

    The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used...

    Authors: Georg Boelke, Uwe Berger, Karl-Christian Bergmann, Carsten Bindslev-Jensen, Jean Bousquet, Julia Gildemeister, Marek Jutel, Oliver Pfaar, Torsten Sehlinger and Torsten Zuberbier

    Citation: Clinical and Translational Allergy 2017 7:33

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  37. Content type: Erratum

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Ioana Agache, Susanne Lau, Antonella Muraro, Marek Jutel, Graham Roberts, Cezmi Akdis, Matteo Bonini, Moises Calderon, Thomas Casale, Ozlem Cavkaytar, Linda Cox, Pascal Demoly, Breda Flood, Eckard Hamelmann…

    Citation: Clinical and Translational Allergy 2017 7:32

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    The original article was published in Clinical and Translational Allergy 2016 6:5

  38. Content type: Erratum

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela…

    Citation: Clinical and Translational Allergy 2017 7:31

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    The original article was published in Clinical and Translational Allergy 2016 6:24

  39. Content type: Erratum

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Eva-Maria Varga, Gunter Sturm, Antonella Muraro, Cezmi A. Akdis, Darío Antolín-Amérigo, M. Beatrice Bilò, Danijela Bokanovic, Moises A. Calderon, Ewa Cichocka-Jarosz, Joanna N. G. Oude Elberink, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange…

    Citation: Clinical and Translational Allergy 2017 7:30

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    The original article was published in Clinical and Translational Allergy 2016 6:6

  40. Content type: Erratum

    Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:

    Authors: Sangeeta Dhami, Ulugbek Nurmatov, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Pascal Demoly, Stephen Durham, Ronald Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…

    Citation: Clinical and Translational Allergy 2017 7:29

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    The original article was published in Clinical and Translational Allergy 2016 6:12

  41. Content type: Brief communication

    Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatm...

    Authors: Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling and Urs Christian Steiner

    Citation: Clinical and Translational Allergy 2017 7:27

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  42. Content type: Meeting abstracts

    Authors: Ibon Eguiluz Gracia, Carmen Rondón, Paloma Campo, Ana Prieto, Lina Mayorga, Luisa Galindo, Ana Molina, Miguel Blanca, Maria Jose Torres, Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Shigeharu Fujieda, Tomohiro Yoshimoto, Naruhito Iwasaki, Tamar Smulders…

    Citation: Clinical and Translational Allergy 2017 7(Suppl 3):28

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    This article is part of a Supplement: Volume 7 Supplement 3

  43. Content type: Review

    Cow’s milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as we...

    Authors: Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M. Fleischer, Ralf G. Heine, Michael Levin, Mario C. Vieira and Adam T. Fox

    Citation: Clinical and Translational Allergy 2017 7:26

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    The Correction to this article has been published in Clinical and Translational Allergy 2018 8:4

    The Editorial to this article has been published in Clinical and Translational Allergy 2017 7:34

  44. Content type: Review

    The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we...

    Authors: Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J. Ansotegui, Moises Calderon, Cemal Cingi, Stephen Durham, Roy Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol…

    Citation: Clinical and Translational Allergy 2017 7:24

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