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  • Poster presentation
  • Open Access

A new allergic rhinitis therapy (MP29-02*) provides nasal and ocular symptom relief days faster than current firstline monotherapies

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Clinical and Translational Allergy20155 (Suppl 4) :P34

  • Published:


  • Rhinitis
  • Allergic Rhinitis
  • Fluticasone
  • Fluticasone Propionate
  • Nasal Spray


The efficacy of MP29-02* (a novel intranasal formulation of azelastine hydrochloride [AZE] and fluticasone propionate [FP] in an advanced delivery system) in providing overall nasal and ocular symptom relief vs AZE, FP or placebo (PLA) has been assessed.


Six hundred and ten moderate-to-severe SAR patients (≥12 yrs) were randomized into a double-blind, PLA-controlled, 14-day, parallel-group, trial (NCT00660517) to MP29-02*, AZE, FP or PLA nasal sprays (1 spray/nostril bd; daily dose: AZE=548μg; FP=200μg) [1]. Change from baseline (CFB) in reflective total of 7 symptom scores (rT7SS; AM + PM, max=42) was assessed post-hoc. CFB in rT7SS and each nasal (congestion, itching, rhinorrhea, sneezing) and ocular symptom (itching, redness, watering; max=6 each) was assessed over time.


Overall, MP29-02* patients showed greater reduction in rT7SS vs FP, AZE & PLA (relative diff: 52% to FP (p=0.0013), 56% to AZE (p=0.0004)) evident from treatment day 1 vs FP (p=0.0072), AZE (p=0.0336) or PLA (p<0.0001) and sustained for 14 days. The level of relief achieved by MP29-02* patients on Day 2 (-5.52) was not achieved before Day 5 by FP patients or Day 8 by AZE patients. This pattern of rapid, sustained and superior symptom relief by MP29-02* was observed for each nasal and ocular symptom, which was not the case with FP and AZE. MP29-02* provided significantly superior nasal congestion relief than FP or AZE from Day 2; the level of congestion relief provided by MP29-02* on Day 2 (-0.77) was not achieved before Day 6 and Day 9 for FP and AZE, respectively. MP29-02* provided significantly superior ocular itching relief vs FP from Day 2 and vs AZE from Day 3; the ocular itch relief provided by MP29-02* on Day 2 (-0.77) was not achieved before Day 10 for FP-patients. Similarly, the level of ocular itch relief provided by MP29-02* on Day 3 (-1.06) was not achieved by AZE-patients before Day 11.


The consistent and rapid effect in alleviating all nasal and ocular symptoms is unique to MP29-02* and contributes to its superiority over AZE and FP. The time advantage over firstline therapy in achieving significant relief and sustained effect should improve patient concordance. MP29-02* is considered a new standard of care in AR.

* Dymista

Authors’ Affiliations

Dept of Otorhinolaryngology, Head & Neck Surgery, University Hospitals Leuven, Leuven, Belgium
Department of Oto-Rhinolaryngology, Ghent University Hospital, Ghent, Belgium
University of Cologne, IMSIE, Cologne, Germany
The Royal National Throat Nose and Ear Hospital, London, UK
Meda, Corporate Clinical Affairs, Bad Homburg, Germany
Academic Medical Center, Department of Otorhinolaryngology, Amsterdam, Netherlands


  1. Meltzer E, Ratner P, Bachert C, Carr W, Berger W, Canonica GW, et al: . Int Arch Allergy Immunol. 2013, 161 (4): 369-77.View ArticlePubMedGoogle Scholar


© Hellings et al. 2015

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