Skip to main content
  • Poster presentation
  • Open access
  • Published:

Eosinophilic esophagitis in Portuguese children: clinical and allergological characterisation


Eosinophilic esophagitis (EoE) is a clinicopathologic entity defined by symptoms of esophageal dysfunction and histological eosinophil (eos) inflammation. Its patients (pts) commonly present concurrent reactivity to both food and aeroallergens, outlining the importance of an allergological evaluation.


Clinical and sensitization profile description of the pediatric population with EoE diagnosis (EoEd) in our Immunoallergology Department.


Retrospective study using the EoE database (Feb2009-Mar2014) of pts up to 18 years (yrs). Outcomes were characterization of demographic, symptomatic, laboratorial (peripheral eos, total and specific IgE), endoscopic and histological features and sensitization profile (prick and patch tests).


We included 24 pts [(21M,3F;10.6(4-16)yrs)]; median age at EoEd: 7(1-14)yrs. Average between symptom onset and EoEd:19±30 months. Average follow-up for 28 (5-60) months.

Most frequent symptoms (%): dysphagia (54), impaction (50), GERD-like symptoms (42), abdominal and/or epigastric pain (42), vomiting (33). Most frequent onset symptom: dysphagia (46%). 96% of pts had prior history of atopy (p<0.001). Average peripheral Eos count 627cel/mL (170-1830) and total IgE 524kU/L (25-2798). At EoEd, the most common endoscopic finding were furrows(79.2%). Histologically 29% had>40eos/High Power Field and 33% had microabcesses (which were more frequent in patients with impactation [p<0.1]).

After EoEd, 96% had confirmed allergy with 92% to aeroallergens (p<0.01) and 75% to food (P=0.023).The main allergens were(%): food [shelfish(61), milk(44), cereals(39), egg(39), meat(33), nuts(33), fish(22), fresh fruits(11)]; mites (75); pollens (54.2).

After a 12 month therapy, all had symptomatic improvement; with 8.3% achieving biopsy normalization.

Of those with pre-EoEd allergenic testing, all had acquisition of new sensitizations (food and/or aeroallergens) after EoEd.


The first and the most frequent symptom was dysphagia. The prevalence of allergic sensitization was >95%. The potential clinical severity of EoE justifies the multidisciplinary evaluation for clinical, diagnostic and therapeutic workup.

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Marcelino, J., Aguiar, R., Duarte, F. et al. Eosinophilic esophagitis in Portuguese children: clinical and allergological characterisation. Clin Transl Allergy 5 (Suppl 3), P44 (2015).

Download citation

  • Published:

  • DOI: