Skip to main content

Advertisement

Food sensitisation profiles in school-aged children from China and Russia

Article metrics

  • 480 Accesses

Background

Compared to Europe, little is known about sensitization to food and inhalant sources in Russia and China.

Objective

To explore sensitization profiles of school-aged children in urban and rural settings from Russia (Western Siberia) and South-Eastern China.

Methods

In the EuroPrevall-INCO survey, primary school children (7-10 years) from randomly selected schools in China (Hong Kong [urban/n=401], Guangzhou [urban/n=402], Shaoguan [rural/n=349]) and Russia (Tomsk [urban&rural/n=1230]) were first screened by a short questionnaire for self-reported food allergy. Subsequently, cases and randomly sampled controls underwent a more detailed clinical evaluation by standardized questionnaire, and all were assessed for sensitization by SPT and ImmunoCAP analysis against 27 different foods and 8 inhalants. A subset from Hong Kong (n=216) and Tomsk (n=318) was further screened for sensitization to 56 food and 6 inhalant allergens by custom-made microarray.

Results

Shrimp (7-25%) and crab (4-9%) were the most common food sensitizations in Chinese children, except in Hong Kong, where egg (17%) and milk (15%) sensitization was higher than that to shrimp (13%). In all other sites <7% was sensitized to milk and egg. Children from Tomsk were mostly sensitized to hazelnuts and fruits (~6%) and this was associated with birch pollen and Bet v 1 sensitization. Hazelnut sensitization was <4% in China and fruit sensitization was almost absent in Guangzhou. Sensitization to house dust mite (HDM) was exceptionally high in China (p39%), especially in Hong Kong (73%), compared to Tomsk (13%). IgE titers to HDM were significantly lower in Shaoguan (median 2.0 kUA/L) than in Hong Kong and Guangzhou (median 71.8 and 26.2 kUA/L, respectively).

Conclusion

Sensitization profiles in Tomsk are dominated by birch pollen cross-reactivity, similar to what is common in Central and Northern Europe. In contrast, sensitization to HDM and sea foods dominated the picture in China. Whether house dust mite sensitization is (partly) at the basis of the high prevalence of seafood sensitization (e.g. via Der p 10/tropomyosin) or whether it is the seafood-rich diet, is currently under investigation.

Author information

Correspondence to Mareen Datema.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Keywords

  • Food Allergy
  • House Dust
  • House Dust Mite
  • Primary School Child
  • Birch Pollen