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Clinical and Translational Allergy

Open Access

sIgE to peanut components does not accurately predict the severity of allergy in subjects suspected of peanut allergy

  • Rob Klemans1,
  • Yolanda Meijer1,
  • Francine Van Erp1,
  • Cornelis Van der Ent1,
  • Carla Bruijnzeel-Koomen1,
  • Henny Otten1,
  • Edward Knol1,
  • Suzanne Pasmans1 and
  • André Knulst1
Clinical and Translational Allergy20155(Suppl 3):P34

Published: 30 March 2015


Logistic Regression AnalysisPediatric PopulationMultivariate Logistic Regression AnalysisAllergic PatientMultivariable Logistic Regression Analysis


Many recent studies have shown the superior diagnostic accuracy of specific IgE (sIgE) to Ara h 2 compared to sIgE to peanut extract in diagnosing peanut allergy. The aim of this study was to analyze the association between severity and sensitization levels (by SPT, sIgE to peanut extract and peanut components Ara h 1, 2, 3 and 8).


Peanut allergic adults (n=94) and children (n=100) with a suspected peanut allergy were included. sIgE levels were measured by ImmunoCAP (Uppsala, Sweden). In all subjects the adapted Mueller score was used with one additional category for no symptoms (0-5): 0; no symptoms/peanut tolerant, 1; oral allergy symptoms, 2; cutaneous/mucosal symptoms, 3; gastrointestinal symptoms, 4; respiratory symptoms, 5; cardiovascular symptoms. A severe reaction was defined as a Mueller score of 4 or 5. Univariate and multivariate logistic regression analysis was used to calculate odds ratio’s.


Children had significantly higher Mueller scores than adults (P=0.003) and were therefore analyzed separately. In children 12 patients had a severe allergy, in adults 15 patients. In the pediatric population, none of the predictors was significantly associated with a severe peanut allergy, since the 95% CI of the OR of all predictors included the value 1. In the adult population, sIgE to Ara h 2 (OR 1.03, 95% CI 1.01-1.06) and sIgE to peanut extract (OR 1.02, 95% CI 1.003-1.05) were significantly associated with a severe peanut allergy. A multivariable logistic regression analysis was not possible due to the low number of severely allergic patients. The AUC values of sIgE to Ara h 2 and sIgE to peanut extract in the adult population were 0.81 (95% CI 0.69-0.93) and 0.70 (95% CI 0.54-0.86), respectively (compared to 0.77 (0.64-0.89) and 0.69 (0.53-0.85) in the pediatric population).


In children no predictor was significantly associated with severity of peanut allergy. In adults, specific IgE to Ara h 2 was a better predictor for severe peanut allergy than sIgE to peanut extract, but was still suboptimal for this purpose.

Authors’ Affiliations

University Medical Center Utrecht, Utrecht, The Netherlands


© Klemans et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.