- Oral presentation
- Open Access
Enquiring About Tolerance (EAT) study – feasibility of early introduction of allergenic foods and impact on breastfeeding
© Perkin et al; licensee BioMed Central Ltd. 2015
- Published: 30 March 2015
- Deleterious Effect
- Study Data
- Population Data
- Median Consumption
- Early Infancy
The introduction of multiple allergenic foods in early infancy has not been attempted in a randomized controlled trial setting and the impact on breastfeeding performance is unknown.
1,303 exclusively breastfeeding (EBF) infants were recruited to the EAT Study at 3 months of age and randomized to either EBF until around 6 months of age (Standard Introduction Group - SIG) or early introduction of 6 allergenic foods (cow's milk, egg, fish, wheat, sesame and peanut) alongside breastfeeding (Early Introduction Group - EIG). Data from the UK 2010 Infant Feeding Survey (IFS) was used to compare EAT Study data to UK population data.
Overall per protocol compliance in the SIG was high. In the EIG, cow's milk proved to be the easiest food to introduce while sesame and egg had the slowest pace of introduction. Non-consumption rates were very low for all foods. By 5 months the median consumption frequency in the EIG was 2-3 times a week for all 6 foods with minimal consumption in the SIG. Comparisons between groups for each food at every time point were statistically significant (p< 0.0005).
The EAT study is confirmation that the introduction of 6 of the principal allergenic foods in early infancy is achievable and without any deleterious effect on breastfeeding rates.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.