Food-induced anaphylaxis among a population of adolescents – Report from the BAMSE survey

The epidemiology and early-life risk factors of food-induced anaphylaxis (“anaphylaxis”) in adolescence are incompletely understood.

To study aspects and early-life risk factors of food-induced anaphylaxis amongst adolescents.

Parent-reported questionnaire data from 2-3 months, and 1, 2 and 16 years from a large birth cohort were used (N=3153). Immunoglobulin E to 14 common allergens were analysed at 4 (n=2283) and 16 years (n=2510). In a subset of 371 adolescents, 15 additional food allergen extracts or components were analysed at 16 years. Data on dispensed adrenaline autoinjectors and inhaled steroids were extracted from a national register. Severity of food reactions and asthma were defined. The incidence of anaphylaxis was analysed in association with early-life risk factors.

In the 12 months prior to the study, 8.5% of adolescents reacted to food and 0.8% had anaphylaxis; the annual incidence of the latter was 761/100,000 person years. Only one-third of adolescents when experiencing anaphylaxis had contacted healthcare. Restricting analyses to these adolescents yielded an annual incidence of 240/100,000 person years. In the 24-months prior to the study, adrenaline autoinjectors were dispensed for 67% of those with reported symptoms defined by us as anaphylaxis according to international guidelines. The strongest early-life risk factors for anaphylaxis included sensitisation to foods at 4 years (OR=20.9, 95%CI 6.8-64) and food reactions (OR=17.7, 95%CI 6.91-45.2) between 1-2 years.

Anaphylaxis in adolescence is more common than previously reported in the literature. Early-life sensitisation and reactions to foods increase anaphylaxis risk in adolescence by more than 15-fold.

Affiliations

1. Sachs’ Children and Youth Hospital, Stockholm, Sweden

   • Mirja Vetander
   •  & Magnus Wickman

2. Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden

   • Mirja Vetander
   • , Jennifer L. P. Protudjer
   • , Inger Kull
   • , Anna Bergström
   •  & Magnus Wickman

3. Centre for Allergy, Karolinska Institute, Stockholm, Sweden

   • Mirja Vetander
   • , Jennifer L. P. Protudjer
   • , Gunnar Lilja
   • , Inger Kull
   • , Anna Bergström
   •  & Eva Östblom

4. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden

   • Gunnar Lilja
   • , Inger Kull
   •  & Eva Östblom

5. Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute and University Hospital, Stockholm, Sweden

   • Marianne van Hage

Corresponding author

Correspondence to Jennifer L. P. Protudjer.

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