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Food-induced anaphylaxis among a population of adolescents – Report from the BAMSE survey
Clinical and Translational Allergy volume 5, Article number: O25 (2015)
Background
The epidemiology and early-life risk factors of food-induced anaphylaxis (“anaphylaxis”) in adolescence are incompletely understood.
Objective
To study aspects and early-life risk factors of food-induced anaphylaxis amongst adolescents.
Methods
Parent-reported questionnaire data from 2-3 months, and 1, 2 and 16 years from a large birth cohort were used (N=3153). Immunoglobulin E to 14 common allergens were analysed at 4 (n=2283) and 16 years (n=2510). In a subset of 371 adolescents, 15 additional food allergen extracts or components were analysed at 16 years. Data on dispensed adrenaline autoinjectors and inhaled steroids were extracted from a national register. Severity of food reactions and asthma were defined. The incidence of anaphylaxis was analysed in association with early-life risk factors.
Results
In the 12 months prior to the study, 8.5% of adolescents reacted to food and 0.8% had anaphylaxis; the annual incidence of the latter was 761/100,000 person years. Only one-third of adolescents when experiencing anaphylaxis had contacted healthcare. Restricting analyses to these adolescents yielded an annual incidence of 240/100,000 person years. In the 24-months prior to the study, adrenaline autoinjectors were dispensed for 67% of those with reported symptoms defined by us as anaphylaxis according to international guidelines. The strongest early-life risk factors for anaphylaxis included sensitisation to foods at 4 years (OR=20.9, 95%CI 6.8-64) and food reactions (OR=17.7, 95%CI 6.91-45.2) between 1-2 years.
Conclusion
Anaphylaxis in adolescence is more common than previously reported in the literature. Early-life sensitisation and reactions to foods increase anaphylaxis risk in adolescence by more than 15-fold.
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Correspondence to Jennifer L. P. Protudjer.
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Vetander, M., Protudjer, J.L.P., Lilja, G. et al. Food-induced anaphylaxis among a population of adolescents – Report from the BAMSE survey. Clin Transl Allergy 5, O25 (2015). https://doi.org/10.1186/2045-7022-5-S3-O25
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Keywords
- Steroid
- Asthma
- Birth Cohort
- Additional Food
- Annual Incidence
