Skip to main content

Evaluation of peach tolerance after one year of sublingual immunotherapy with LTP (Pru p 3) in allergic patients sensitises to food by LTPs

Rationale

In Southern Europe Pru p3 is the primary sensitizer of plants fruit and responsible for severe reactions. Specific immunotherapy (SIT) brings a new perspective to treat those patients. The aim was to evaluate the effect of sublingual immunotherapy (SLIT) to peach in allergic patients with systemic symptoms.

Methods

Forty-six peach allergic patients confirmed as positive by skin test, ImmunoCAP IgE and/or a double-blind placebo-controlled food-challenge (DBPCFC) were included. After one year of treatment we evaluated peach tolerance with DBPCFC using 5, 40, and 120 g of fresh peach with a mixture of yogurt, orange juice, coffee dried, coconut, and oatmeal flakes. Placebo meals consisted of the same ingredients, without fresh apple.

Results

From the total group, 21 patients (45%) had anaphylaxis and 25 (55%) urticaria and/or angioedema. The 82,6% showed sensitization to other plant foods proteins and 69,5% showed sensitization to pollens. The DBPCFC was performed in 20 patients who completed the first year of SLIT. The 90% patients had good tolerance to peach during DBPCFC as well as fresh peach at home. Only 2 patients (10%) presented reactions. One patient suffered an anaphylactic reaction after 45 g of the active mixture, and other patient suffered angioedema after ingest complete peach at home.

Conclusion

These results showed a high percentage of patients who tolerated peach after one year receiving SLIT. There were no differences in the clinical patterns between the patients with good response and those patients with reactions.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Francisca Gómez.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bagos, G., Gómez, F., Salas, M. et al. Evaluation of peach tolerance after one year of sublingual immunotherapy with LTP (Pru p 3) in allergic patients sensitises to food by LTPs. Clin Transl Allergy 5, O14 (2015). https://doi.org/10.1186/2045-7022-5-S3-O14

Download citation

Keywords

  • Urticaria
  • Angioedema
  • Orange Juice
  • Anaphylactic Reaction
  • Food Protein