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Clinical and Translational Allergy

Open Access

Evaluation of peach tolerance after one year of sublingual immunotherapy with LTP (Pru p 3) in allergic patients sensitises to food by LTPs

  • Gador Bagos1,
  • Francisca Gómez1,
  • María Salas1,
  • Paloma Campo1,
  • Luisa Galindo1,
  • María Jose Torres1,
  • Cristobalina Mayorga2,
  • Lucía Jimeno3 and
  • Miguel Blanca1
Clinical and Translational Allergy20155(Suppl 3):O14

https://doi.org/10.1186/2045-7022-5-S3-O14

Published: 30 March 2015

Rationale

In Southern Europe Pru p3 is the primary sensitizer of plants fruit and responsible for severe reactions. Specific immunotherapy (SIT) brings a new perspective to treat those patients. The aim was to evaluate the effect of sublingual immunotherapy (SLIT) to peach in allergic patients with systemic symptoms.

Methods

Forty-six peach allergic patients confirmed as positive by skin test, ImmunoCAP IgE and/or a double-blind placebo-controlled food-challenge (DBPCFC) were included. After one year of treatment we evaluated peach tolerance with DBPCFC using 5, 40, and 120 g of fresh peach with a mixture of yogurt, orange juice, coffee dried, coconut, and oatmeal flakes. Placebo meals consisted of the same ingredients, without fresh apple.

Results

From the total group, 21 patients (45%) had anaphylaxis and 25 (55%) urticaria and/or angioedema. The 82,6% showed sensitization to other plant foods proteins and 69,5% showed sensitization to pollens. The DBPCFC was performed in 20 patients who completed the first year of SLIT. The 90% patients had good tolerance to peach during DBPCFC as well as fresh peach at home. Only 2 patients (10%) presented reactions. One patient suffered an anaphylactic reaction after 45 g of the active mixture, and other patient suffered angioedema after ingest complete peach at home.

Conclusion

These results showed a high percentage of patients who tolerated peach after one year receiving SLIT. There were no differences in the clinical patterns between the patients with good response and those patients with reactions.

Authors’ Affiliations

(1)
Allergy Service, Carlos Haya Hospital, Malaga, Spain
(2)
Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain
(3)
ALK-Abello, Madrid, Spain, Spain

Copyright

© Bagos et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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