Volume 4 Supplement 3

6th Drug Hypersensitivity Meeting (DHM 6)

Open Access

Anaphylaxis during specific subcutaneous immunotherapy against ragweed allergen -- case record

  • Besim Prnjavorac1,
  • Amina Deljkić1,
  • Albina Sinanović1,
  • Rifat Sejdinović1,
  • Amila Mehedović2,
  • Jasna Jukić3,
  • Katarina Krajina4,
  • Lejla Šaranović5,
  • Nedžada Irejiz1,
  • Indira Kašibović6,
  • Tamer Bego7,
  • Maja Malenica7,
  • Tanja Dujić7,
  • Sabina Semiz7 and
  • Adlija Čaušević7
Clinical and Translational Allergy20144(Suppl 3):P75


Published: 18 July 2014


Recommended by Resolution of Immunotherapy, issued by EAACI, Specific immunotherapy (SIT) was established as a mainstream method of treating allergic diseases. SIT produces long term challenges. SIT team should be aware that at first injection of allergen, the immunotherapy may cause a long lasting reaction. Anaphylaxis during SIT is very rare, but it is possible. We've experienced anaphylaxis after four year of SIT, against ragweed allergen.


A fifty four year old female went into anaphylactic shock after four years of SIT against ragweed allergen. Before the start of SIT, complete diagnostic procedures had been performed. Intradermal skin tests were performed for standard pallet of contact, inhalation, and nutritional allergens. The female patient tested positive for Ragweed (high positive), fungi (aspergillum fumigates, altenaria), and milk. Total IgE was measured using Enzyme Linked Immunoassay (ELISA).


After injection of the SIT maintenance dose (0.2 ml of second concentration of allergen, (product of authorized Immunologic Laboratory Production) against ragweed, anaphylaxis developed within five minutes. The first manifestation was itchy palms and itching of eyes, followed by a rash. A dose of 0.0005 gram epinephrine was administered subcutaneously immediately. After the epinephrine injection, an IV rout was established with 0.9 % saline infusion, 0.2 gram of hydrocortisone, and 0.020 gram of chloropiramin was administered intramuscularly. No bronchoobstruction developed. Patient displayed anxiety. After an hour of treatment, the symptoms of anaphylaxis subsided.


Anaphylaxis can develop as a complication of SIT with any possible manifestation. Treatment of anaphylaxis should start immediately after initial symptoms. The use of epinephrine is recommended.

Authors’ Affiliations

General Hospital Tešanj, Pulmology, Immunology-allergology
Department of Internal Medicine, Gastroenterology-hepatology
General Hospital Tešanj, Department of Anestesiology
University Pittsburgh, Pensilvania, Medical Science
Department of Internal Medicine, Gatroenterology
Department of Internal Medicine, Pulmology, Immunology-allergology
Faculty of Pharmacy, Clinical Biochemistry


© Prnjavorac et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.