- Poster presentation
- Open Access
Basophil activation test in allergic patients to platins undergoing rapid desensitization
Clinical and Translational Allergy volume 4, Article number: P34 (2014)
Desensitization (DST) has become a cornerstone in the management of immediate hypersensitivity reactions (HSRs) to chemotherapic agents. It is the only effective procedure for overcoming HSRs to first-line therapy, thus representing an important advance in patients' treatment and prognosis. Nevertheless, there are still no good biomarkers to monitor DST safety and effectiveness. The basophil activation test (BAT) has greater applicability in difficult cases with inconclusive diagnosis and when other diagnostic tests (skin tests and serum specific IgE) have not been standardized, as in drug-induced reactions. The main goal of our study was to assess BAT as a test to monitor rapid DST in patients allergic to platins.
We studied 7 oncologic patients who presented platin allergy and 4 healthy volunteers who had never been exposed to platins. We performed the BAT immediately before DST to platins, assessing CD 203c and CD63 expression on basophils. All patients were evaluated at least in 2 different DST.
BAT was positive in 6 patients (85.7%), with increased expression of CD203c and CD63 in 6 and 3 patients, respectively. Subsequent BAT analysis in different DST procedures showed that the test remained positive with an even greater expression of CD203c and CD63 on basophils after platins exposure. Some patients with positive BAT reacted during DST, in spite of being premedicated, showing the correlation between BAT results and clinical outcomes. Further investigation is necessary to determine BAT predictive values and its clinical applicability.
We developed a BAT to platins that presented good sensitivity in our study. Short-term DST to platinum drugs does not induce persistent hyporresponsiveness on basophils, highlighting the need to maintain DST in allergic patients to platins.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Giavina-Bianchi, P., Caiado, J., Picard, M. et al. Basophil activation test in allergic patients to platins undergoing rapid desensitization. Clin Transl Allergy 4 (Suppl 3), P34 (2014). https://doi.org/10.1186/2045-7022-4-S3-P34
- CD63 Expression
- Hypersensitivity Reaction
- Oncologic Patient
- Allergic Patient
- Clinical Applicability