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Patterns of response and drug involved in patients with multiple drug hypersensitivity syndrome

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Clinical and Translational Allergy20144 (Suppl 3) :P138

  • Published:


  • High Risk
  • Large Population
  • Ibuprofen
  • Amoxicillin
  • Hypersensitivity Reaction


Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically unrelated drugs. This has been specially studied in IgE-mediated hypersensitivity reactions to antibiotics and more recently in T-cell-mediated reactions. However, studies focusing in MDH in large populations are lacking. The aim of our study was to describe a well-characterized group of patients diagnosed of MDH.


We analyzed retrospectively all patients with a confirmed diagnosis of drug hypersensitivity evaluated in our allergy department between January 2005 and December 2010.


A MDH was diagnosed in 48 (2.41%) of the 1989 patients evaluated, being 32 females, with a mean age of 50±14,43 years. A total of 137 episodes were reported: 80 (58.39%) suggested an IgE-mediated reaction, 37 (27%) a non-immunologic mechanism (cross-reactive to NSAIDs) and 20 (14.55%) a T-cell mediated reaction. The percentage of MHD in patients with IgE-mediated reactions (9.78%) was higher compared to those with T-cell mediated reactions (5.23%) and non-immunologic reactions (1.91%) (p<0,0001). The drugs most frequently involved were dypirone (13.6%), ciprofloxacin (12.1%), amoxicillin-clavulanic acid (11.4%), amoxicillin (10%), ASA (8.6%), ibuprofen (7.1%) and moxifloxacin (5.7%). Sensitivity to 2 chemically unrelated drugs was diagnosed in 44 patients and to 3 drugs in 4. The most frequent clinical entities were anaphylaxis/shock (42.85%) and urticaria (34.92%).


Patients with IgE-mediated reactions have a higher risk for developing MHD. More studies are needed to confirm this finding.

Authors’ Affiliations

Regional University Hospital of Malaga, Allergy unit, Spain


© Doña et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.