Skip to main content
  • Poster presentation
  • Open access
  • Published:

Humoral biomarkers of latex allergy


Although latex allergy is decreasing in several countries, it is still a global health problem that is associated with life-threatening reactions. The main objective of this study is to identify clinical and laboratory factors associated with sensitization and allergy to latex, including latex-specific IgE, IgG4 and IgA.


Observational study in a cohort of 400 children and adolescents with defect of neural tube closure. Patients underwent clinical interview and had their blood drawn to measure specific serum IgE, IgG4 and IgA to latex. The prevalence of sensitization and allergy to latex were calculated and possible associations with clinical and laboratory variables were analyzed.


The prevalence of sensitization and allergy to latex in patients presenting defects in neural tube closure was 33.2% and 12.2%, respectively. Cutaneous manifestations of latex allergy were the most common (79.6%), but anaphylaxis was observed in 4.75% of patients. Clinical and surgical factors associated with latex allergy were identified and a symptom score to screening patients was developed. Concentration of specific IgE to latex >0.77 kUA/l presented good accuracy in differentiating asymptomatic sensitization from allergy. Measurement of specific IgE to recombinant allergens also showed good accuracy in the diagnosis of allergy. The specific serum IgG4 concentration was negatively associated with allergy to latex, but this was not observed for specific IgA.


Higher concentration of specific IgE to latex and Hevb5, lower concentration of specific IgG4 to latex and symptom score ¡Ý 40% were associated with latex allergy.

Author information

Authors and Affiliations


Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Giavina-Bianchi, P., Garro, L.S., Aun, M.V. et al. Humoral biomarkers of latex allergy. Clin Transl Allergy 4 (Suppl 3), P128 (2014).

Download citation

  • Published:

  • DOI: