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  • Open Access

Association between HLA-B*1502 allele and aromatic antiepileptic drugs-induced hypersensitivity syndrome reactions and the HLA-B*15:02 pharmacogenetics screening in autistic spectrum disorder

  • Chonlaphat Sukasem1,
  • Nattawat Ngamsamut2,
  • Ananya Sinrachatanant3,
  • Bhunnada Chamkrachchangpada3,
  • Tan-kam Teerarat3,
  • Montri Chamnanphon4,
  • Apichaya Puangpetch4 and
  • Penkhae Limsila3
Clinical and Translational Allergy20144(Suppl 3):P124

https://doi.org/10.1186/2045-7022-4-S3-P124

Published: 18 July 2014

Keywords

Autistic Spectrum DisorderCarbamazepineLamotrigineAutistic ChildOxcarbazepine

Poster presentation

Some autistic children also have symptoms of depression, anxiety or obsessive-compulsive disorder (OCD). Aromatic anti-epileptic drugs (AEDs) may be used as a mood-stabilizing medication to treat these symptoms, including carbamazepine (CBZ), oxcarbazepine (OX-CBZ), and lamotrigene (LMG). Moreover, one in every four autistic spectrum disorder children have seizures, the use of AED becomes imperative in managing symptoms. Previous studies found a strong association between HLA-B*1502 and carbamazepine (CBZ)-induced cutaneous adverse reactions in Thai epileptic patients. This study aimed to identify whether HLA-B*1502 is associated with AEDs-induced hypersensitivity syndrome (HSS) reactions and also determine the frequency of HLA-B*15:02 in autistic spectrum disorder (ASD) in Thailand. In this study, patients that developed fever and cutaneous eruptions in the presence or absence of organ involvement with exposure to carbamazepine (CBZ), phenytoin (PHY), or lamotrigine (LTG) were enrolled. HLA-B* 15:02 was then determined in 21 patients with AED-induced HSS (6 with CBZ-HSS, 4 PHY-HSS patients and 11 LTG-HSS patients and 292 children with ASD. HLA-B genotyping using PCR-SSOP methods was performed. HLA-B*15:02 was observed with HSS-induced by AEDs, which included carbamazepine (n=4; 66.7%), phenytoin (n=2; 50%), and lamotrigine (n=3; 27%). In addition, the allele frequencies of HLA-B*15:02 in ASD was 14.72% (43/292). HSS-induced by CBZ, PHY and LMG is strongly, moderately and slightly associated with HLA-B*15:02 in Thai patients, respectively. Our findings suggest that HLA-B*15:02 testing before AED therapy would be effective at risk of hypersensitivity and applicable to ASD populations providing hope for prevention in the future.

Authors’ Affiliations

(1)
Laboratory for Pharmacogenomics, Ranathibodi Hospital Mahidol University, Thailand
(2)
Ministry of Public, Department of Mental Health Services, Yuwaprasart Waithayopathum-Child and Adolescent Psychiatric Hospital, Thailand
(3)
Ministry of Public, Department of Mental Health Services, Yuwaprasart Waithayopathum-Child and Adolescent Psychiatric Hospital, Thailand
(4)
Laboratory for Pharmacogenomics, Ranathibodi Hospital Mahidol University, Department of Pathology, Thailand

Copyright

© Sukasem et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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