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HLA-B*15:02 genotype associated with hypersensitivity syndrome to lamotrigine in Thai population

Background

Lamotrigine is a commonly used in psychiatric patients. The aims of this study were to determine the possible associations of lamotrigine-induced hypersensitivity syndrome with the HLA-B alleles in Thai patients. HLA-B*58:01 allele was also observed in Han Chinese patients with epilepsy and lamotrigine-induced SCARs (severe cutaneous adverse drug reactions).

Method

A total of 133 patients, including 11 patients with lamotrigine-induced hypersensitivity syndrome (MPE; maculo-papular exanthema, SJS; Stevens-Johnson syndrome and TEN; toxic epidermal necrolysis), 9 lamotrigine-tolerant controls and 113 healthy controls were included in this study. HLA-B genotyping was performed. This case-control study was approved by the Ethics Committee of Ramathibodi Hospital.

Results

HLA-B*15:02 allele was present in 27.3% (3/11) of Thai patients with lamotrigine-induced hypersensitivity syndrome but in only 11.1% (1/9) of lamotrigine-tolerant controls and 13.2% of 113 healthy controls (P-value <0.05). Other HLA-B allele, including HLA-B*58:01 was observed in a case group.

Conclusion

Our results support the hypothesis that HLA-B*15:02 contribute to the genetic susceptibility to lamotrigine-induced hypersensitivity syndrome and may be valuable as potential biomarkers for prediction lamotrigine-induced hypersensitivity syndrome in Thai population. A major limitation of this study was the size of the sample available for the analysis. Confirmation of these results in a larger, independent sample is needed.

Author information

Correspondence to Napatrupron Koomdee.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Keywords

  • Drug Reaction
  • Adverse Drug Reaction
  • Lamotrigine
  • Genetic Susceptibility
  • Chinese Patient