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Introductory lecture: Pollen food allergy syndrome

The term pollen-food allergy syndrome (PFAS) defines a series of clinical symptoms appearing shortly after the ingestion of plant-derived foods in subjects with pollen allergy. The patients with PFAS are primarily allergic to pollen and subsequently react to food allergens as a consequence of the homology between pollen and plant-food proteins. The two highly conserved proteins responsible for the large majority of cases of pollen-food allergy syndrome are the pathogenesis-related proteins group 10 (PR-10), including the major birch pollen allergen Bet v 1 and homologous proteins in different fruits and vegetables, and profilin, a plant pan-allergen present in cell structure of all the vegetable kingdom. Although it has been generally thought that the clinical expression of the pollen food-allergy syndrome is uniquely the so-called “oral allergy syndrome”, recent reports suggest that the ingestion of particular foods may be associated with systemic symptoms as well. Recombinant PR-10 proteins and recombinant profilins from different sources are presently available for diagnostic purposes. The presentation will review the available data about the clinical expression, diagnosis, and therapy of the pollen-food allergy syndrome.

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Correspondence to Riccardo Asero.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Food Allergy
  • Food Allergen
  • Clinical Expression
  • Pollen Allergen
  • Birch Pollen