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Soybean allergy in a population with a low prevalence of betulacae pollen allergy and a high soybean consumption

  • Yuma Fukutomi1,
  • Sigrid Sjölander2,
  • Magnus Borres3,
  • Takuya Nakazawa1,
  • Toyota Ishii1,
  • Satoshi Nakayama4,
  • Akira Tanaka4,
  • Masami Taniguchi1,
  • Akemi Saito1,
  • Hiroshi Yasueda1,
  • Hiroyuki Nakamura5 and
  • Kazuo Akiyama1
Clinical and Translational Allergy20111(Suppl 1):P89

https://doi.org/10.1186/2045-7022-1-S1-P89

Published: 12 August 2011

Keywords

Food AllergyAdult PlantAllergic PatientPollen AllergyRespiratory Allergy

Background

Recent evidence has shown that birch pollen-related soybean allergy mediated by Gly m 4 is common in central Europe. However, the impact of sensitization to Gly m 4 in soybean allergic patients in a population with a low prevalence of Betulaceae pollen allergy and a high soybean consumption is unknown.

Methods

The aim of this study was to elucidate the prevalence of sensitization to rGly m 4 in adults with soybean allergy, and to analyze the diagnostic efficiency of the IgE antibody to rGly m 4 (ImmunoCAP®) in soybean allergy in central Japan. Twenty-one soybean-allergic patients were prospectively recruited from Jan. to Dec. 2009, and their levels of IgE antibody to rGly m 4 were compared with those of general alder pollen-allergic control subjects without soybean allergy (n=85).

Results

Although sensitization to alder pollen was not prevalent in the general outpatients of allergy departments, all the soybean–allergic patients were sensitized to alder pollen and rGly m 4. Sixty-two percent of the general alder pollen-allergic control subjects were also sensitized to rGly m 4. However, the levels of IgE antibody to rGly m 4 in soybean-allergic patients were markedly higher than those in alder pollen-allergic control subjects. The area under the receiver-operating characteristics curve for levels of IgE antibody to rGly m 4 in the diagnosis of soybean allergy was 0.86, which was significantly higher than that to the natural soybean extracts.

Conclusion

A strong relationship between adult soybean allergy and sensitization to rGly m 4 was also observed in this population with high soybean consumption. The level of IgE antibody to CAP-rGly m 4 was an effective tool in discriminating soybean allergy from general alder pollen-allergy. This result highlights the impact of respiratory allergy to pollen-derived cross-reactive allergens on the epidemics of adult plant food allergy.

Authors’ Affiliations

(1)
Sagamihara National Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara Kanagawa, Japan
(2)
Phadia AB, Uppsala, Sweden
(3)
Göteborg University, Department of Pediatrics, Sahlgrenska Academy, Göteborg, Sweden
(4)
Phadia KK, Tokyo, Japan
(5)
Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa Ishikawa, Japan

Copyright

© Fukutomi et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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