Skip to content

Advertisement

  • Poster presentation
  • Open Access

Precocious eczema and unexpected anaphylaxis to seafood

  • 1 and
  • 1
Clinical and Translational Allergy20111 (Suppl 1) :P7

https://doi.org/10.1186/2045-7022-1-S1-P7

  • Published:

Keywords

  • Atopic Dermatitis
  • Angioedema
  • Food Allergen
  • House Dust Mite
  • Positive Skin

Background

Assessment of allergic food reactions may be complicated by cross-reactivity among certain food families and seemingly unrelated allergens. Analysis can identify protein sequence and allergenic properties. Fish and its derived play an important role in nutrition, they may also be a potent food allergen. Gad-c1, Parvalbumin, the major codfish allergen, is considered as a panallergen as in seafood the Tropomyosin (muscle-derived protein) have been recently demonstrated in invertebrates such as cockroaches, mites, shrimp. The clinical symptoms related to IgE-mediated fish allergy are frequently urticaria, angioedema, mild oral symptoms, worsening atopic dermatitis, respiratory symptoms (rinitis, asthma),gastrointestinal (nausea,vomiting). Anaphylaxis may occur.

Objective

In view of a possible cross-reactivity between food allergens and related allergens from environmental sources.

Methods

A 4 yrs children, family atopic risk, severe atopic eczema in the first year and anaphylaxis to fish and seafood during first introduction at 4 years. Positive skin test to egg, RAST ovoalbumin 1.13 KUI/L, RAST at age two Grasses 23.2 KUI/L. Anaphylaxis ( Sampson,2003- 2nd) to codfish at first injestion, to shrimp after 3 months.

Results

Positive skin to house dust mite (HDM) and cockroach mix were reported. At control, positive RASTto grasses, mites, and recombinant Pen1, Gad 1.

Conclusions

some subjects allergic to HDM or cockroach show substantial IgE antibody reactivity to the major shrimp allergen Pen a 1 (tropomyosin). Based on inhibition with cockroach and dust mite extracts, this reactivity appears to be due to cross-reacting tropomyosins. This patient showed the literature evolution in cross reactivity: precocious sentitization to egg, correlation to mite and linkage to mite and seafood. And asthma? Follow up of course.

Authors’ Affiliations

(1)
ISS -State Hospital - San Marino Republic (RSM), Pediatrics, Borgo Maggiore, San Marino

References

  1. Jenkins JA, Breiteneder H, Mills EN: Evolutionary distance from human homologs reflects allergenicity of animal food proteins. J Allergy Clin Immunol. 2007, 120 (6): 1399-405. 10.1016/j.jaci.2007.08.019. Epub 2007 Nov 1View ArticlePubMedGoogle Scholar

Copyright

© Menna and Romeo; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement