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The result of desensitization of children with severe Ig-E mediated cow’s milk allergy


Our aim is to demonstrate the success of desensitization in children with severe Ig-E mediated cow's milk allergy.

Materials and methods

10 children from 6 to 10 year of age were desensitize by introducing increasing doses of cow milk (CM) till 200 ml or the highest tolerated quality for approximally 6 months. Ig-E mediated cow’s milk allergy was convinced by skin prick test and/or specific IgE. Double – blind placebo controlled food challenge has confirmed the diagnosis. All children were observed on the first and the third months after concluding the desensitization.


Eight of the children (80%) successfully achieved the amount of 200 ml of CM daily in six months, with no adverse reactions. One of the children (10%) tolerated 32 ml and another one (10%) reached to 128 ml. All children did not present any symptoms, taking whole CM even on the third month.


We successfully desensitized 8 of 10 children and induced tolerance to a smaller amount of CM in another 2. The protocol is well tolerated and results are reliable.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Novakova, S., Novakov, I. & Joncheva, M. The result of desensitization of children with severe Ig-E mediated cow’s milk allergy. Clin Transl Allergy 1 (Suppl 1), P106 (2011).

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