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The result of desensitization of children with severe Ig-E mediated cow’s milk allergy

Background

Our aim is to demonstrate the success of desensitization in children with severe Ig-E mediated cow's milk allergy.

Materials and methods

10 children from 6 to 10 year of age were desensitize by introducing increasing doses of cow milk (CM) till 200 ml or the highest tolerated quality for approximally 6 months. Ig-E mediated cow’s milk allergy was convinced by skin prick test and/or specific IgE. Double – blind placebo controlled food challenge has confirmed the diagnosis. All children were observed on the first and the third months after concluding the desensitization.

Results

Eight of the children (80%) successfully achieved the amount of 200 ml of CM daily in six months, with no adverse reactions. One of the children (10%) tolerated 32 ml and another one (10%) reached to 128 ml. All children did not present any symptoms, taking whole CM even on the third month.

Conclusions

We successfully desensitized 8 of 10 children and induced tolerance to a smaller amount of CM in another 2. The protocol is well tolerated and results are reliable.

Author information

Correspondence to Silviva Novakova.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Public Health
  • Placebo
  • Adverse Reaction
  • Skin Prick Test
  • Control Food