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- Open Access
Oour experience in the early management of patients with IgE- mediated cow’s milk allergy (CMA)
© Boné et al; licensee BioMed Central Ltd. 2011
- Published: 12 August 2011
- Food Allergen
- Elimination Diet
- Oral Allergy Syndrome
- Strict Avoidance
- Open Food Challenge
Strict avoidance of food allergens has been advised for sensitization prevention and management. However, recent studies suggest that is the early introduction of food allergens, rather that avoidance, which might induce tolerance.
January 2007-December 2009: 48 infants (< 1 year old) were diagnosed in our Unit of IgE mediated CMA after a complete evaluation (anamnesis and physical examination, skin prick test and specific serum IgE levels) Subsequently, ALL patients underwent an open food challenge (OFC). The OFC was postponed only in 1 case: a 4-month old boy with previous anaphylaxis whose parents refused OFC until age one.
In the OFC, we do not look for reactions, but for a well-tolerated dose as a starting point for reaching tolerance.
To evaluate the effectiveness and safety of our performance.
Most patients (44/48), presented a negative OFC (36/44) or mild symptoms (2 oral allergy syndrome, 1 urticaria, 1 rhinoconjunctivitis, 4 vomiting) Subsequently, patients underwent a gradual dose increase at home. Slower increases for cases with mild/moderate symptoms were recommended. The remaining patients (4/48), presented a positive OFC (3/48 mild anaphylaxis) or persistent symptoms in home dosing (1/48 daily vomiting). An elimination diet was prescribed, followed by a second challenge 3-6 months later • it was negative in 2 patients, who continued gradual increases and a free diet at age two, and positive in 2, who began a standardized desensitization treatment.
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