Skip to main content

Table 3 Top ten CpG sites in meta-analysis of ComR in relation to methylation in whole blood showing the same direction of effect in discovery and replication cohort

From: Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium

CpG CHR Great annotation (distance to TSS) Discovery Replication-EGEA Meta-analysis
Coef SE P N Coef SE P Nb P.meta Direction
cg24788483a 10 HABP2 (− 401132), TCF7L2 (+ 201,644) − 1.31E−02 2.11E−03 4.62E−10 54 − 1.348 0.544 0.013 56 (53/3) 8.49E−10
cg15223066 10 ITGB1 (− 23,896), NRP1 (+ 354472) − 8.56E−03 1.39E−03 6.65E−10 54 − 0.658 0.470 0.161 92 (89/3) 1.13E−06
cg26909813 17 RPRML (-605) − 2.68E−02 4.15E−03 1.06E−10 54 − 0.621 0.539 0.249 95 (92/3) 1.52E−06
cg02341571 15 PATL2 (+ 150) − 1.69E−02 2.71E−03 4.39E−10 54 − 0.253 0.388 0.515 64 (62/2) 2.59E−06
cg00269245 16 SLC12A3 (− 41116), NUP93 (+ 93986) 1.13E−02 1.86E−03 1.14E−09 54 0.832 1.109 0.453 70 (68/2) 4.62E−06  +  + 
cg24833566 4 MTNR1A (− 152680), FAT1 (+ 15608) 1.02E−02 1.71E−03 2.38E−09 54 0.658 0.758 0.386 77 (74/3) 6.87E−06  +  + 
cg25881850 11 KCNK4 (− 1426) − 1.23E−02 2.23E−03 3.43E−08 54 − 0.838 0.816 0.304 68 (67/1) 9.09E−06
cg24730612 14 FOS (− 95503), TMED10 (− 6640) − 1.47E−02 2.50E−03 4.15E−09 54 − 0.260 0.489 0.595 62 (61/1) 1.09E−05
cg23250019 11 SLC29A2 (+ 818) 2.15E−02 4.00E−03 7.62E−08 54 0.645 0.541 0.234 82 (79/3) 1.61E−05  +  + 
  1. P.meta: the P value of meta-analysis of results from discovery and EGEA by using weighted Z-scores method
  2. Direction: the direction of regression coefficient in discovery and EGEA
  3. A list of all 129 significant CpG sites identified in discovery cohort and the information of replication in EGEA is shown in Additional file 2: Table S9
  4. aThe CpG site was replicated with meta P value < 1.14 × 10–7
  5. bN (persA/ComR), N varies from one CpG to another because of the methylC-capture sequencing method used and different QC criteria in EGEA
\