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Table 1 Reported immunological events contributing to the induction of allergic sensitization by specific pollen sources and individual major pollen allergens

From: Initiating pollen sensitization – complex source, complex mechanisms

 

Plant family

Plant species

 

Epithelium + alarmin secretion

Oxidative stress

Neutrophils

TLR4 signaling-

DCs expression of surface molecules

Induction of Th2 polarization

 

Proteolytic activity

Non-proteolytic interaction

PAR2 interaction

TSLP

IL-33

IL-25

ROS induction

IL-8 expression

Dependent?

Independent?

OX40L

ST2

Notch Ligands

Capability

Insufficiency of major allergens

Tree

Betulaceae

White birch (Betula verrucosa)

 

[52, 56, 140, 143]

  

[61]

  

[69]

 

[85]

   

[95]

[94]

[94]

Betulaceae

Hazelnut (Corylus avellana)

                

Cupressaceae

Japanese cypress (Chamaecyparis obtusa)

 

[56]

        

[85]

     

Cupressaceae

Japanese cedar (Cryptomeria japonica)

 

[140]

    

[79]

   

[85]

     

Cupressaceae

Meditereanen cypress (Cupressus sempervirens)

 

[140]

              

Cupressaceae

Mountain cedar (Juniperus ashei)

 

[144]

     

[71]

        

Oleaceae

Olive tree (Olea europaea)

                

Salicaceae

Black poplar (Populus nigra)

 

[144]

     

[71]

        

Grass

Poaceae

Timothy grass (Phleum pratense)

       

[71]

       

[115]

Poaceae

Rye grass (Lolium perenne)

 

[53]

     

[71]

        

Poaceae

Kentucky bluegrass (Poa pratensis)

 

[53, 56, 143]

        

[85]

     

Poaceae

Bermuda grass (Cynodon dactylon)

 

[53]

     

[71]

        

Poaceae

Orchard grass (Dactylis glomerata)

 

[144]

              

Weed

Asteraceae

Short ragweed (Ambrosia artemisiifolia)

 

[54, 55, 140, 145]

  

[66]

[74, 76]

 

[70]

[67]

[66, 67]

[85]

[66]

[76]

 

[66, 76]

[116]

Asteraceae

Mugwort (Artemisia vulgaris)

    

[64]

    

[84]

      

Asteraceae

Giant ragweed (Ambrosia trifida)

 

[143]

              

Amaranthaceae

Redroot pigweed (Amaranthus retroflexus)

       

[71]

        

Amaranthaceae

Burning bush (Kochia scoparia)

       

[71]

        

Amaranthaceae

Russian thistle (Salsola kali)

   

[60]

   

[71]

        

Cannabaceae

Japanese hop (Humulus japonicus)

       

[60]

        

Allergen

Betulaceae

White birch (Betula verrucosa)

Bet v 1

 

[57]

            

[94]

Oleaceae

Olive tree (Olea europaea)

Ole e 1

 

[58]

             

Cupressaceae

Japanese cedar (Cryptomeria japonica)

Cry j 1

  

[59]

            

Cupressaceae

Cypress (Cupressus arizonica)

Cup a 1

   

[75]

       

[75]

   

Poaceae

Timothy grass (Phleum pratense)

Phl p 5

      

[115]

      

[115]

[115]

Asteraceae

Short ragweed (Ambrosia artemisiifolia)

Amb a 1

             

[117]

[116]

Asteraceae

Short ragweed (Ambrosia artemisiifolia)

Amb a 11

[112]