Fig. 1
From: Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper
Mechanism PAMP-induced innate immunity responses to microbial agents. Examples for PAMPs (activators of the innate immune system) Endotoxin (LPS) signaling through TLR4-pathway expression TLR4 LPS induced inflammatory response (e.g. RSV increased TLR4) although LPS causes inflammation in everyone, people with asthma tend to be more sensitive several proteins are involved in LPS-response. Peptidoglycan signaling by TLR2 and, PGRPs (peptidoglycan recognition proteins), and NODs (nucleotide-binding oligomerization domain molecules) b(1 → 3)-glucans (polymers of glucose produced in fungi, plants and some bacteria) Dectin-1, expressed on macrophages and neutrophils, is the b-glucan receptor Dectin-1 may function as a T cell co-stimulatory molecule, suggesting that b-glucan stimulation may be a link between innate and adaptive immune response