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Table 2 Clinical characteristics of CholU patients with elevated specific IgE levels against supMGL-1304 (MG+) and CholU patients with normal low supMGL-1304 (MG−)

From: Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients

  MG+
n = 4
MG−
n = 21
P value
Age [years]    
 Median (range) 35.5 (21–57) 31.0 (18–55)  
 Mean ± SD 37.3 ± 9.0 32.9 ± 2.5 0.504
Sex    
 M:F 0:4 11:10 0.105
BMI [kg/m2]    
 Median (range) 21.4 (20.2–25.2) 24.7 (20.0–32.3)  
 Mean ± SD 22.1 ± 1.1 25.1 ± 0.8 0.119
Clinical data    
 Persistence of disease [years]    
  Median (range) 3.5 (1.0–29.0) 5.0 (1.0–20.0)  
  Mean ± SD 9.3 ± 6.6 7.6 ± 1.3 0.681
 CholUSI   n = 19  
  Median (range) 16.5 (15–19) 16.0 (10–20)  
  Mean ± SD 16.7 ± 0.8 16.0 ± 0.5 0.540
 UAS Provo n = 3 n = 10  
  Median (range) 5 (5, 6) 4 (3–5)  
  Mean ± SD 5.3 ± 0.5 4.1 ± 0.7 0.036
 Itch Score Provo n = 3 n = 10  
  Median (range) 2 (2, 3) 1 (1, 2)  
  Mean ± SD 2.3 ± 0.5 1.3 ± 0.5 0.069
 Wheal Score Provo n = 3 n = 10  
  Median (range) 3 (3) 3 (2, 3)  
  Mean ± SD 3 ± 0 2.8 ± 0.4 0.167
Atopic features    
 Erlangen Atopy score   n = 20  
  Median (range), 14.5 (12–20) 9.0 (5–14)  
  Mean ± SD 15.3 ± 1.7 9.0 ± 0.7 0.026
 Total IgE [kU/l]   n = 15  
  Median (range) 1360.5 (278.0–4377.0) 71.9 (14.8–600.0)  
  Mean ± SD 1844.0 ± 886.0 154.5 ± 169.2 0.152
 Pos. Sx1 screening (inhalative allergen mix) n = 3 n = 15  
2 (67%) 9 (60%) 1.0
 Pos. sIgE to other skin resident fungi   n = 17  
3 (75%) 1 (6.3%) 0.012
Skin testings    
 ASwST 1:100 pos. (n) 4 (100%) 15 (71%) 0.540
 ASwST wheal size diameter (mm)   n = 20  
  Median (range) 9.5 (0.8–1.5) 5.5 (0–1.3)  
  Mean ± SD 10.5 ± 2.7 5.6 ± 4.2 0.04
 ASwST flare size diameter (mm)   n = 20  
  Median (range) 33.5 (1.43.7) 12.0 (04.5)  
  Mean ± SD 29.5 ± 0.9 17 ± 4 0.060
 ASST pos (n) 0 (0%) 5 (24%) 0.55
 ASST wheal size diameter (mm)   n = 20  
  Median (range) 0 (0) 0 (0–9)  
  Mean ± SD 0 ± 0 1.9 ± 3.2 0.017
 ASST flare size diameter (mm)   n = 20  
  Median (range) 0 (04) 0 (019)  
  Mean ± SD 10 ± 1.7 5.2 ± 8.9 0.075
 ACh i.c. pos (n) 1 (25%) 10 (47.6%) 0.604
 ACh i.c wheal size diameter (mm)    
  Median (range) 0 (0–0.8) 0 (0–10)  
  Mean ± SD 2.0 ± 1.2 3.1 ± 3.9 0.626
 ACh i.c. flare size diameter (mm)    
  Median (range) 5.0 (5–55) 5.0 (0–35)  
  Mean ± SD 19 ± 20.9 13.3 ± 1.6 0.0675
  1. Statistical significant differences are shown in bold, trends in italics
  2. ACh i.c. acetylcholine intracutaneous injection, ASwST autologous sweat skin test, ASST autologous serum skin test, BMI body mass index, CholUSI Cholinergic Urticaria Severity Index, Provo provocation, SD standard deviation, UAS urticaria activity score