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Table 2 Clinical characteristics of CholU patients with elevated specific IgE levels against supMGL-1304 (MG+) and CholU patients with normal low supMGL-1304 (MG−)

From: Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients

 

MG+

n = 4

MG−

n = 21

P value

Age [years]

   

 Median (range)

35.5 (21–57)

31.0 (18–55)

 

 Mean ± SD

37.3 ± 9.0

32.9 ± 2.5

0.504

Sex

   

 M:F

0:4

11:10

0.105

BMI [kg/m2]

   

 Median (range)

21.4 (20.2–25.2)

24.7 (20.0–32.3)

 

 Mean ± SD

22.1 ± 1.1

25.1 ± 0.8

0.119

Clinical data

   

 Persistence of disease [years]

   

  Median (range)

3.5 (1.0–29.0)

5.0 (1.0–20.0)

 

  Mean ± SD

9.3 ± 6.6

7.6 ± 1.3

0.681

 CholUSI

 

n = 19

 

  Median (range)

16.5 (15–19)

16.0 (10–20)

 

  Mean ± SD

16.7 ± 0.8

16.0 ± 0.5

0.540

 UAS Provo

n = 3

n = 10

 

  Median (range)

5 (5, 6)

4 (3–5)

 

  Mean ± SD

5.3 ± 0.5

4.1 ± 0.7

0.036

 Itch Score Provo

n = 3

n = 10

 

  Median (range)

2 (2, 3)

1 (1, 2)

 

  Mean ± SD

2.3 ± 0.5

1.3 ± 0.5

0.069

 Wheal Score Provo

n = 3

n = 10

 

  Median (range)

3 (3)

3 (2, 3)

 

  Mean ± SD

3 ± 0

2.8 ± 0.4

0.167

Atopic features

   

 Erlangen Atopy score

 

n = 20

 

  Median (range),

14.5 (12–20)

9.0 (5–14)

 

  Mean ± SD

15.3 ± 1.7

9.0 ± 0.7

0.026

 Total IgE [kU/l]

 

n = 15

 

  Median (range)

1360.5 (278.0–4377.0)

71.9 (14.8–600.0)

 

  Mean ± SD

1844.0 ± 886.0

154.5 ± 169.2

0.152

 Pos. Sx1 screening (inhalative allergen mix)

n = 3

n = 15

 

2 (67%)

9 (60%)

1.0

 Pos. sIgE to other skin resident fungi

 

n = 17

 

3 (75%)

1 (6.3%)

0.012

Skin testings

   

 ASwST 1:100 pos. (n)

4 (100%)

15 (71%)

0.540

 ASwST wheal size diameter (mm)

 

n = 20

 

  Median (range)

9.5 (0.8–1.5)

5.5 (0–1.3)

 

  Mean ± SD

10.5 ± 2.7

5.6 ± 4.2

0.04

 ASwST flare size diameter (mm)

 

n = 20

 

  Median (range)

33.5 (1.4–3.7)

12.0 (0–4.5)

 

  Mean ± SD

29.5 ± 0.9

17 ± 4

0.060

 ASST pos (n)

0 (0%)

5 (24%)

0.55

 ASST wheal size diameter (mm)

 

n = 20

 

  Median (range)

0 (0)

0 (0–9)

 

  Mean ± SD

0 ± 0

1.9 ± 3.2

0.017

 ASST flare size diameter (mm)

 

n = 20

 

  Median (range)

0 (0–4)

0 (0–19)

 

  Mean ± SD

10 ± 1.7

5.2 ± 8.9

0.075

 ACh i.c. pos (n)

1 (25%)

10 (47.6%)

0.604

 ACh i.c wheal size diameter (mm)

   

  Median (range)

0 (0–0.8)

0 (0–10)

 

  Mean ± SD

2.0 ± 1.2

3.1 ± 3.9

0.626

 ACh i.c. flare size diameter (mm)

   

  Median (range)

5.0 (5–55)

5.0 (0–35)

 

  Mean ± SD

19 ± 20.9

13.3 ± 1.6

0.0675

  1. Statistical significant differences are shown in bold, trends in italics
  2. ACh i.c. acetylcholine intracutaneous injection, ASwST autologous sweat skin test, ASST autologous serum skin test, BMI body mass index, CholUSI Cholinergic Urticaria Severity Index, Provo provocation, SD standard deviation, UAS urticaria activity score
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Clinical and Translational Allergy

ISSN: 2045-7022

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