Health-related quality of life worsens by school age amongst children with food allergy

Table 2 Linear regression analyses for children with specialist-diagnosed food allergy, by proxies of severity (n = 59)

HRQL	Unadjusted			Model 1^†			Model 2^‡
HRQL	B	95% CI	p value	B	95% CI	p value	B	95% CI	p value
A. Symptom severity
Overall
Less^§	Ref			Ref			Ref
More^¶	0.95	0.29–1.61	0.005	0.46	− 0.13–1.05	0.12	0.51	− 0.09–1.10	0.09
FA
Less^§	Ref			Ref			Ref
More^¶	0.89	0.20–1.59	0.01	0.28	0.33–0.89	0.37	0.27	− 0.36–0.89	0.39
EI
Less^§	Ref			Ref			Ref
More^¶	1.01	0.34–1.67	0.004	0.55	− 0.07–1.16	0.81	0.59	− 0.03–1.22	0.06
SDL
Less^§	Ref			Ref			Ref
More¶	0.96	0.13–1.78	0.02	0.48	− 0.34–1.31	0.24	0.57	− 0.25–1.39	0.17
B. EAI prescription
Overall
No	Ref			Ref			Ref
Yes	0.99	0.44–1.55	0.001	0.70	0.17–1.23	0.01	0.57	− 0.01–1.15	0.05
FA
No	Ref			Ref			Ref
Yes	1.22	0.62–1.81	<0.001	0.94	0.39–1.50	0.001	0.97	0.36–1.58	0.002
EI
No	Ref			Ref			Ref
Yes	1.04	0.44–1.63	0.001	0.68	0.13–1.24	0.02	0.55	− 0.06–1.16	0.08
SDL
No	Ref			Ref			Ref
Yes	0.78	0.07–1.50	0.03	0.53	− 0.21–1.28	0.16	0.29	− 0.51–1.10	0.47
C. Number of concomitant allergic disease
Overall
0–2	Ref			Ref			Ref
3	0.93	0.29–1.57	0.005	0.41	− 0.13–0.95	0.13	0.42	− 0.12–0.95	0.13
FA
0–2	Ref			Ref			Ref
3	0.81	0.13–1.49	0.02	0.24	− 0.32–0.79	0.40	0.23	− 0.33–0.80	0.41
EI
0–2	Ref			Ref			Ref
3	0.93	0.27–1.58	0.006	0.39	− 0.18–0.95	0.17	0.39	− 0.17–0.96	0.17
SDL
0–2	Ref			Ref			Ref
3	1.07	0.31–1.82	0.006	0.63	− 0.13–1.38	0.10	0.64	− 0.11–1.38	0.09

95% CI 95th percent confidence interval, EAI epinephrine autoinjector, EI emotional impact, FA food anxiety, HRQL health-related quality of life, SDL social and dietary limitations
^†Adjusted for age, EAI prescription and number of concomitant allergic diseases
^‡Adjusted for age, EAI prescription, number of concomitant allergic diseases and region
^§Less severe symptoms: skin, oral, gastroenteritis and/or rhinoconjunctivitis
^¶More severe symptoms: respiratory and/or cardiovascular

ISSN: 2045-7022