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Table 4 Relationship between AATD or AAT genotypes and severe persistent asthma

From: Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites

  Severe persistent asthma OR (95%CI) P value* Multivariable correction**
PI*MM 1.2700 (0.6–2.69) 0.532 0.382
PI*MS 0.9760 (0.44–2.15) 0.953 0.665
PI*SS 0.00000078 (0–Inf) 0.983 0.992
PI*MZ 0.8910 (0.12–6.92) 0.912 0.953
PI*SZ 0.000000791 (0–Inf) 0.989 0.995
SAATD 6.3600 (0.57–71.5) 0.134 0.711
AATD 0.5680 (0.17–1.88) 0.355 0.992
  1. PI: protease inhibitor, SAATD (severe alpha 1 antitrypsin deficiency, < 57 mg/dl), AATD (alpha1 antitrypsin deficit, < 100 mg/dl)
  2. * Binary logistic regression
  3. ** Adjusted for age, conjunctivitis, polyposis, ex-smokers, passive smokers