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Table 4 Differences in cytokine and transcription factor expression between hypertrophic tonsils and recurrent tonsillitis

From: Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis

Cytokine or transcription factor Mean differences recurrently infected minus hypertrophic group
Univariate Multivariate
n Difference of means (95% CI) Adjusted difference of means (95% CI) Adjustments
T-helper1
 IFN-γ 88 0.061 (− 0.32, 0.44)
P = 0.75
 Tbet 89 − 0.40 (− 0.76, − 0.034)
P = 0.03
− 0.21 (− 0.61, 0.18)
P = 0.29
Age
T-helper2
 IL-13 89 − 0.74 (− 1.8, 0.36)
P = 0.18
 GATA3 89 − 0.12 (− 0.42, 0.18)
P = 0.43
T-helper17
 IL-17 89 − 0.35 (− 0.80, 0.096)
P = 0.12
− 0.087 (− 0.57, 0.40)
P = 0.72
Age
 RORC2 89 0.014 (− 0.35, 0.38)
P = 0.94
T-regulatory
 IL-10 89 − 0.26 (− 0.61, 0.0871)
P = 0.14
− 0.0070 (− 0.38, 0.36)
P = 0.97
Age
 IL-37 87 − 0.48 (− 0.77, − 0.19)
P = 0.001
− 0.31 (− 0.63, − 0.0021)
P = 0.049
Age
 FOXP3 89 0.091 (− 0.31, 0.49)
P = 0.65
 TGF-β 89 − 0.0077 (− 0.32, 0.30)
P = 0.96
Type I/III interferons
 IFN-α 87 − 0.41 (− 1.5, 0.7)
P = 0.47
 IFN-β 88 − 0.21 (− 1.0, 0.61)
P = 0.62
 IL-28 89 − 0.64 (− 1.5, 0.2)
P = 0.13
 IL-29 87 − 0.57 (− 1.5, 0.31)
P = 0.15
  1. Data are expressed as mean differences as a recurrently infected group minus hypertrophic group. The data were analysed using backward stepwise linear regression analysis after logarithmic transformation. Only significant co-factors were used as adjustments in the final model
  2. CI, confidence interval; IFN, interferon; Tbet, T-box transcription factor; IL, interleukin; GATA3, GATA-binding factor 3; RORC, RAR-related orphan receptor C; FOXP, forkhead box protein; TGF, tumour growth factor
  3. Significant values are shown in italic