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Table 3 Intratonsillar cytokine and transcription factor expression in hypertrophic tonsils and recurrent tonsillitis

From: Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis

Cytokine or transcription factor Tonsillar hypertrophy
n = 47
Recurrent tonsillitis
n = 42
Median (IQR) Median (IQR)
T-helper1
 IFN-γ 58 (37, 90) 76 (32, 117)
 Tbet 54 (31, 83) 34 (22, 60)
T-helper2
 IL-13 1.2 (0.03, 3.7) 0.45 (0.02, 2.2)
 GATA3 27 (16, 36) 18 (12, 39)
T-helper17
 IL-17 10 (5.6, 19) 7.3 (4.1, 13)
 RORC2 15 (7.2, 31) 20 (10, 28)
T-regulatory
 IL-10 49 (24, 74) 35 (21, 64)
 IL-37 0.26 (0.15, 0.37) 0.14 (0.10, 0.24)
 FOXP3 46 (20, 87) 48 (24, 80)
 TGF-β 163 (105, 232) 171 (120, 225)
Type I/III interferons
 IFN-α 15 (0.59, 62) 9.7 (0.27, 56)
 IFN-β 24 (2.7, 101) 22 (2.1, 103)
 IL-28 31 (3.1, 88) 12 (1.4, 75)
 IL-29 11 (2.3, 34) 3.7 (1.3, 26)
  1. Values are arbitrary units × 104 relative to EF1α
  2. IQR, interquartile range; IFN, interferon; Tbet, T-box transcription factor; IL, interleukin; GATA3, GATA-binding factor 3; RORC, RAR-related orphan receptor C; FOXP, forkhead box protein; TGF, tumour growth factor