Fig. 3From: The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): verification of nasal allergen challenge procedures in a study utilizing an investigational immunotherapy for cat allergyEffect of Cat-SPIRE on TNSS and PNIF. Participants (n = 19) experienced an initial peak in TNSS and a peak reduction in PNIF at 15 min following allergen challenge, followed by a gradual return to baseline values. Following treatment, participants experienced a significant reduction in TNSS at 15 min (p < 0.05), 30 min (p < 0.05), 1 h (p < 0.01), and 2 h (p < 0.05). Fall in PNIF in response to allergen challenge was also reduced after treatment though not evident in statistical analysisBack to article page