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Table 6 Evaluation of factors affecting time to resolutiona

From: Effectiveness of icatibant for treatment of hereditary angioedema attacks is not affected by body weight: findings from the Icatibant Outcome Survey, a cohort observational study

Effect (numerator) Odds ratio 95% CI P value
Univariate analysisb
 BMI (≥ 25 kg/m2) 1.52 0.072
 C1-INH rescue medication (yes) 0.66 0.097
 Affected site: skin (yes) 0.74 0.118
 Type of administration (HCP) 1.49 0.133
 Time to first injection (≥ 1 h) 0.78 0.142
 Country    0.019c
Multivariate analysisd
 BMI (≥ 25 kg/m2) 4.46 2.24–8.89 < 0.0001
 C1-INH rescue medication (yes) 0.31 0.19–0.50 < 0.0001
 Affected site: skin (yes) 0.65 0.43–1.00 0.049
  1. BMI body mass index; C1-INH C1-inhibitor; CI confidence interval; HCP health care provider
  2. aModel of probability that time to resolution < 5 h
  3. bOnly effects with P < 0.2 are shown. Complete results are presented in Additional file 1: Table S7
  4. cOverall effect of country on time to resolution
  5. dOnly significant effects are shown. Complete results excluding the two reinjection outliers are presented in Additional file 1: Table S8