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Table 4 Impact of time to treatment on mean time to resolution and duration of attack

From: Effectiveness of icatibant for treatment of hereditary angioedema attacks is not affected by body weight: findings from the Icatibant Outcome Survey, a cohort observational study

Time to treatment

n

Underweight BMI

n

Normal BMI

n

Overweight BMI

n

Obese BMI

Mean ± SD time to resolution

 0 to < 1 h

6

15.6 ± 16.7

155

10.4 ± 12.5

148

7.9 ± 11.0

108

5.4 ± 9.5

 ≥ 1 h

6

10.1 ± 8.4

253

15.0 ± 17.7

201

9.9 ± 12.4

106

15.0 ± 17.4

 P value

 

n.a.

 

0.078

 

0.001

 

< 0.001

 0 to < 2 h

6

15.6 ± 16.7

228

11.8 ± 13.5

193

8.4 ± 12.0

142

6.5 ± 10.1

 ≥ 2 h

6

10.1 ± 8.4

180

15.0 ± 18.6

156

9.8 ± 11.6

72

17.5 ± 19.2

 P value

 

n.a.

 

0.734

 

0.011

 

< 0.001

Mean ± SD duration of attack

 0 to < 1 h

6

15.8 ± 16.7

155

10.7 ± 12.5

148

8.1 ± 11.0

108

5.6 ± 9.5

 ≥ 1 h

6

18.7 ± 12.5

253

21.8 ± 22.0

201

14.8 ± 14.2

106

22.4 ± 20.8

 P value

 

n.a.

 

< 0.001

 

< 0.001

 

< 0.001

 0 to < 2 h

6

15.8 ± 16.7

228

12.3 ± 13.7

193

8.9 ± 12.1

142

6.9 ± 10.2

 ≥ 2 h

6

18.7 ± 12.5

180

24.2 ± 23.8

156

15.8 ± 13.9

72

27.7 ± 22.1

 P value

 

n.a.

 

< 0.001

 

< 0.001

 

< 0.001

  1. Results excluding the two outlier patients are presented in Additional file 1: Table S4
  2. BMI body mass index; n.a. not applicable; statistical comparison was not conducted due to small sample sizes; SD standard deviation; n = the number of attacks