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Table 4 Impact of time to treatment on mean time to resolution and duration of attack

From: Effectiveness of icatibant for treatment of hereditary angioedema attacks is not affected by body weight: findings from the Icatibant Outcome Survey, a cohort observational study

Time to treatment n Underweight BMI n Normal BMI n Overweight BMI n Obese BMI
Mean ± SD time to resolution
 0 to < 1 h 6 15.6 ± 16.7 155 10.4 ± 12.5 148 7.9 ± 11.0 108 5.4 ± 9.5
 ≥ 1 h 6 10.1 ± 8.4 253 15.0 ± 17.7 201 9.9 ± 12.4 106 15.0 ± 17.4
 P value   n.a.   0.078   0.001   < 0.001
 0 to < 2 h 6 15.6 ± 16.7 228 11.8 ± 13.5 193 8.4 ± 12.0 142 6.5 ± 10.1
 ≥ 2 h 6 10.1 ± 8.4 180 15.0 ± 18.6 156 9.8 ± 11.6 72 17.5 ± 19.2
 P value   n.a.   0.734   0.011   < 0.001
Mean ± SD duration of attack
 0 to < 1 h 6 15.8 ± 16.7 155 10.7 ± 12.5 148 8.1 ± 11.0 108 5.6 ± 9.5
 ≥ 1 h 6 18.7 ± 12.5 253 21.8 ± 22.0 201 14.8 ± 14.2 106 22.4 ± 20.8
 P value   n.a.   < 0.001   < 0.001   < 0.001
 0 to < 2 h 6 15.8 ± 16.7 228 12.3 ± 13.7 193 8.9 ± 12.1 142 6.9 ± 10.2
 ≥ 2 h 6 18.7 ± 12.5 180 24.2 ± 23.8 156 15.8 ± 13.9 72 27.7 ± 22.1
 P value   n.a.   < 0.001   < 0.001   < 0.001
  1. Results excluding the two outlier patients are presented in Additional file 1: Table S4
  2. BMI body mass index; n.a. not applicable; statistical comparison was not conducted due to small sample sizes; SD standard deviation; n = the number of attacks