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Table 2 Subject lung function and sputum

From: Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma

 

Allergen challenge

EAR (% change in FEV1)

− 33.67 ± 2.12#

LAR (% change in FEV1)

− 24.47 ± 1.77#

Methacoline PC20 (mg/mL)

 Pre-Ag

7.77 ± 1.88

 24 h post-Ag

2.20 ± 0.51*

Total sputum cells (×106 cells/mL)

 Pre-Ag

3.62 ± 0.64

 24 h Post-Ag

6.59 ± 1.27*

Sputum eosinophils (%)

 Pre-Ag

4.68 ± 1.63

 24 h Post-Ag

12.26 ± 2.68*,#

Blood eosinophils (per 109 WBC)

 Pre-Ag

38 ± 6

 24 h Post-Ag

64 ± 9*

  1. Data are presented as geometric mean ± SEM. There was a significant difference the EAR and LAR % change in FEV1, methacoline PC20, total sputum cells, and sputum and blood eosinophils post-allergen
  2. FEV 1 forced expiratory volume in 1 s; PC20 provocative concentration of methacholine causing a 20% drop in FEV1, Ag allergen, EAR early asthmatic response, LAR late asthmatic response, WBC white blood cells, HPC hemopoietic progenitor cells, EoP eosinophil progenitors
  3. *p < 0.05 comparison to baseline and #p < 0.05 comparison to diluent
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Clinical and Translational Allergy

ISSN: 2045-7022

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