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Table 1 Main characteristics of included studies

From: Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews

Author, Year (Country) Databases searched Search period No of studies relevant to this SR (No of participants) Population Intervention relevant to this SR Allrgens Outcomes relevant to this SR Subgroup analyses relevant to this SR
Abramson, 2010 (Australia) CENTRAL, MEDLINE, EMBASE, CINAHL, AMED, PsycINFO, and handsearching of journals and meeting abstracts 1950–2005 88 RCTs (3459) adults and children with allergic asthma SCIT vs placebo SCIT vs inhaled steroid HDM, pollens, animal dander, moulds, chemically modified allergoids, antigen–antibody complexes Effectiveness, lung function, non-specific BHR, allergen-specific BHR, safety NR
Calamita, 2006 (Brazil) MEDLINE, EMBASE,LILACS and the Cochrane Library 1966–2005 25 RCTS (1706) adults and children with allergic asthma SLIT vs placebo Mites, pollens, mould, dander, latex Effectiveness, lung function, non-specific BHR, safety Age, treatment duration (no details)
Chelladurai, 2013 (USA) MEDLINE, Embase, LILACS and the Cochrane Central Register of Controlled Trials Up to December 21, 2012 4 RCTs (NR) adults and children with allergic asthma SCIT vs SLIT Mites, pollens Effectiveness, safety NR
Compalati, 2009 (Italy) MEDLINE, EMBASE, LILACS, SCOPUS Up to March 31, 2008 9 DBRCTs (452) adults and children with allergic asthma SLIT vs placebo HDM Effectiveness Age (children vs adults)
Erekosima, 2014 (USA) MEDLINE, Embase, LILACS, and the Cochrane Central Register of Controlled Trials 1947-May 21, 2012 38 RCTs (NR) adults and children with allergic asthma ± rhinitis/rhino conjunctivitis SCIT vs any comparator Mites, pollen, dander, mould Effectiveness, lung function, allergen-specific BHR, quality of life, safety NR
Kim, 2013 (USA) Medline, Embase, LILACS, CENTRAL, and the Cochrane Central Register of Controlled Trials Up to May 2012 27 RCTs (NR) Children with allergic asthma ± rhinoconjuctivitis SCIT vs any comparator SLIT vs any comparator SCIT vs SLIT Dust mite, Rye, Cladosporium, Alternaria, Tree mix Effectiveness, quality of life, safety NR
Normansell, 2015 (UK) CENTRAL, MEDLINE, EMBASE, CINAHL, AMED, PsycINFO, Clinical Trials.gov, WHO and handsearching of journals and meeting abstracts Up to March 25, 2015 52 RCTs (5256) adults and children with allergic asthma SLIT vs placebo SLIT vs conventional pharmacotherapy HDM, grass pollen, birch pollen, cockroach, cat dander, Alternaria, Parietaria, olive pollen, Artemisia, HDM + Parietaria (combination) Effectiveness, Exacerbations, Quality of life, safety, BHR Age (children vs adults)
Polzehl, 2006 (Germany) MEDLINE and EMBASE 1970–2001 13 DBRCTs (442) adults and children with allergic asthma SCIT vs. placebo HDM (D. pteronyssinus, D. farinae) Effectiveness, safety, lung function, bronchial provocation NR
Tao, 2013 (China) PubMed, EMBASE and the Cochrane Central Register of Controlled Trials Up to March 2012 16 DBRCTs (794) adults and children with allergic asthma SLIT vs placebo Mite, pollen Effectiveness, lung function, safety Age (children vs adults)