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Fig. 1 | Clinical and Translational Allergy

Fig. 1

From: Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Fig. 1

A tentative MOA including an AOP describing the mechanistic events driving food sensitization induction. Solid boxes and arrows represent events and relationships with substantial evidence for a role in sensitization induction to food proteins. Dashed boxes and dashed arrows represent events, organs cellular components or relationships with circumstantial evidence for a role in the AOP. Ag antigen, GI gastro-intestinal, ILC innate lymphoid cells, mϕ macrophages, NKT natural killer cells, IEL intraepithelial lymphocytes. *Outside the scope of this manuscript

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Clinical and Translational Allergy

ISSN: 2045-7022

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