Fig. 4

Changes in abundance levels, expressed as the natural logarithm of the score fold change (ln[T36/T0]) for keratins in omalizumab responders (OR) and non-omalizumab responders (NOR) at baseline (T0) and after 36 months (T36). A negative value indicates a decrease in keratins at T36; a positive value indicates an increase in keratins at T36. In this case, the p value is high; however, if NOR2 is excluded, the p value falls to 0.002 (Additional file 1). OR and NOR are classified according to whether they experienced a reduction in RBM thickness (OR) or no reduction in RBM thickness (NOR) after 12 months of anti-IgE treatment