Table 4 The association of individual HLA-B allele with lamotrigine induced cutaneous adverse drug reactions (cADR)
HLA-B allele | Lamotrigine induced cADR (n = 16) | Lamotrigine tolerant (n = 50) | Healthy control (n = 580) | cADR cases versus lamotrigine tolerant control | cADR cases versus healthy control | ||
|---|---|---|---|---|---|---|---|
OR (95 % CI) | p value | OR (95 % CI) | p value | ||||
1301 | 2 (12.5) | 6 (12) | 81 (14) | 1.083 (0.468–2.505) | 0.852 | 0.907 (0.403–2.043) | 0.814 |
1502 | 6 (37.5) | 6 (12) | 86 (14.8) | 4.423 (2.142–9.134) | 0.000026 | 3.418 (1.730–6.751) | 0.000273 |
1513 | 1 (6.3) | 0 (0) | 10 (1.7) | 2.064 (1.785–2.386) | 0.029 | 3.128 (0.616–15.886) | 0.279 |
1535 | 1 (6.3) | 1 (2) | 12 (2.1) | 3.128 (0.616–15.886) | 0.279 | 3.128 (0.616–15.886) | 0.279 |
3901 | 1 (6.3) | 1 (2) | 11 (1.9) | 3.128 (0.616–15.886) | 0.279 | 3.128 (0.616–15.886) | 0.279 |
4001 | 3 (18.8) | 13 (24) | 109 (18.8) | 0.743 (0.377–1.464) | 0.389 | 1.000 (0.493–2.027) | 1.000 |
4403 | 4 (25) | 2 (4) | 48 (8.3) | 8.000 (2.669–23.982) | 0.000025 | 3.833 (1.634–8.991) | 0.001 |
4601 | 5 (31.3) | 11 (22) | 101 (17.4) | 1.539 (0.844–3.006) | 0.149 | 2.194 (1.120–4.296) | 0.020 |
5101 | 2 (12.5) | 2 (4) | 43 (7.4) | 3.545 (1.114–11.280) | 0.024 | 1.963 (0.749–5.146) | 0.164 |
5201 | 1 (6.3) | 1 (2) | 16 (2.8) | 3.128 (0.616–15.886) | 0.279 | 2.064 (0.502–8.493) | 0.498 |
5801 | 2 (12.5) | 5 (10) | 116 (20) | 1.330 (0.554–3.190) | 0.523 | 0.591 (0.276–1.265) | 0.173 |