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Table 4 The association of individual HLA-B allele with lamotrigine induced cutaneous adverse drug reactions (cADR)

From: 7th Drug hypersensitivity meeting: part two

HLA-B allele Lamotrigine induced cADR (n = 16) Lamotrigine tolerant (n = 50) Healthy control (n = 580) cADR cases versus lamotrigine tolerant control cADR cases versus healthy control
OR (95 % CI) p value OR (95 % CI) p value
1301 2 (12.5) 6 (12) 81 (14) 1.083 (0.468–2.505) 0.852 0.907 (0.403–2.043) 0.814
1502 6 (37.5) 6 (12) 86 (14.8) 4.423 (2.142–9.134) 0.000026 3.418 (1.730–6.751) 0.000273
1513 1 (6.3) 0 (0) 10 (1.7) 2.064 (1.785–2.386) 0.029 3.128 (0.616–15.886) 0.279
1535 1 (6.3) 1 (2) 12 (2.1) 3.128 (0.616–15.886) 0.279 3.128 (0.616–15.886) 0.279
3901 1 (6.3) 1 (2) 11 (1.9) 3.128 (0.616–15.886) 0.279 3.128 (0.616–15.886) 0.279
4001 3 (18.8) 13 (24) 109 (18.8) 0.743 (0.377–1.464) 0.389 1.000 (0.493–2.027) 1.000
4403 4 (25) 2 (4) 48 (8.3) 8.000 (2.669–23.982) 0.000025 3.833 (1.634–8.991) 0.001
4601 5 (31.3) 11 (22) 101 (17.4) 1.539 (0.844–3.006) 0.149 2.194 (1.120–4.296) 0.020
5101 2 (12.5) 2 (4) 43 (7.4) 3.545 (1.114–11.280) 0.024 1.963 (0.749–5.146) 0.164
5201 1 (6.3) 1 (2) 16 (2.8) 3.128 (0.616–15.886) 0.279 2.064 (0.502–8.493) 0.498
5801 2 (12.5) 5 (10) 116 (20) 1.330 (0.554–3.190) 0.523 0.591 (0.276–1.265) 0.173
  1. OR odds ratio, CI confidence interval