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Fig. 4 | Clinical and Translational Allergy

Fig. 4

From: Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β

Fig. 4

Hypothetical mediation analysis and estimated natural indirect effect (NIE) and natural direct effect (NDE) of maternal probiotic supplementation. The NIE is an estimate of the effect of maternal probiotic ingestion on the development of AD in offspring mediated by increased TSLP levels in breast milk 10 days postpartum. The NDE is an estimate of the effect of maternal probiotic ingestion on the development of AD not mediated through changes in breast milk TSLP concentration 10 days postpartum. This analysis suggests that TSLP does not significantly contribute to, or oppose, the preventative effect of maternal perinatal probiotic supplementation on the development of atopic dermatitis

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Clinical and Translational Allergy

ISSN: 2045-7022

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