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Table 3 Agreement and variability in classification of DBPCFC outcome

From: Standardized food challenges are subject to variability in interpretation of clinical symptoms

  All DBPCFC (n =191) DBPCFC with symptoms (n =111)
  1 2 3 1 2 3
Agreement with initial DBPCFC outcome 79% 82% 87% 65% 69% 78%
  1:2 1:3 2:3 1:2 1:3 2:3
Inter-observer agreement 78% 76% 76% 76% 61% 60%
κ (95% CI) 0.65 (0.56-0.74) 0.59 (0.50-0.68) 0.59 (0.50-0.68) 0.46 (0.39-0.53) 0.35 (0.22-0.48) 0.31 (0.25-0.38)
Overall agreement 69% 50%
  1 2 3 1 2 3
Intra-observer agreement* 77% 83% 88% 67% 70% 81%
κ (95% CI) 0.63 (0.45-0.82) 0.71 (0.54-0.89) 0.77 (0.62-0.92) 0.50 (0.37-0.63) 0.52 (0.39-0.65) 0.60 (0.45-0.60)
  1. DBPCFC, Double Blind Placebo Controlled Food Challenge.
  2. κ, Kappa.
  3. *n =48 (All DBPCFC) and n =27 (DBPCFC with symptoms).
  4. Bold numbers express different observers. For example; 1 = observer 1 and 1:2 = observer 1 versus observer 2.