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Severe asthma: a great clinical challenge


Patients with severe asthma represent a significant unmet clinical need. At present, the underlying mechanisms of severe asthma have not been established yet but it is likely they reflect a heterogenous pattern rather than a single unifying process. The aim of this study is to assess the prevalence of severe asthma as well as the clinical and physiologic characteristics of patients and to establish a pattern occuring in comorbid diseases.


Between the January and December of 2013, a total of 324 consecutive asthmatic adult patients (67% females) attended to at an out - patients clinic (Sezana) were involved in the study. The mean age in these patients was 57.3 +- 2.4 years. The diagnosis of severe asthma was assessed according to the International ERS/ATS guidelines. The demographic criteria, body mass index BMI (kg/m2), skin prick tests (Allergopharma, Germany), smoking habits and comorbidities were analysed.


Severe asthma was present in 10% of patients. The mean age in patients was 67.3+- 1.7 years (59%females). Of them, 14% were active smokers and 24% were former smokers. Sixty- five percent patients had a positive family history of asthma. The average mean time of asthma duration was 14+- 3.2 years. The late onset of asthma (patients above 50 years of age) was observed in 60% of all cases. Atopy, which was estimated on the basis of at least one positive skin prick test, was observed in 66% of patients. In patients showing early onset, severe asthma involved significantly more allergen sensitivity (skin test positivity, 92% vs 26% p<0.01) than in patients with late- onset asthma. The average body mass index was 32.1+- 4.7 kg/m2. The obese patients were more frequently females (60% vs 40%). The comorbid diseases were present in 70% of patients. The most frequent were the comorbid conditions of the upper airways - nasal sinus diseases (54% of patients), mostly in females (44%). Next, there were aspirin sensitivity in females (10%) and OSA (obstructive sleep apnea) in males (10%). Both females and males suffered from GERD (gastroesophageal reflux disease) (15% males vs 10% females), and psychological dysfunction (82% females vs 61% males).


The above results suggest than an adult asthmatic with severe asthma has a positive family history of asthma as well as a late onset of disease with less atopy by skin test and is also more obese (especially females). The prevalence of comorbidites is very high.

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Grzetic-Romcevic, T., Devcic, B. & Sonc, S. Severe asthma: a great clinical challenge. Clin Transl Allergy 5 (Suppl 2), P4 (2015).

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