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Clinical and Translational Allergy

Open Access

PD06 - Early elevated blood eosinophils are predictive for the development of atopic dermatitis in an atopic birth cohort

  • Siri Rossberg1,
  • Kerstin Gerhold1,
  • Georg Menke2,
  • Kurt Zimmermann3,
  • Thomas Geske4,
  • Stock Philippe1 and
  • Susanne Lau1
Clinical and Translational Allergy20144(Suppl 1):P6

Published: 28 February 2014


PlaceboAtopic DermatitisBirth CohortEnterococcus FaecalisEosinophil Count

The value of predictive markers for the development of atopic disease has long been discussed. Contributing to the discourse, we investigated the role of blood eosinophils at 4 and 30 weeks of life and their association with developing atopic dermatitis (AD) in an atopic birth cohort of 606 children enrolled in a randomized placebo controlled trial for prevention of AD.


The infants received the placebo controlled oral treatment with a three times daily applied bacterial lysate (ProSymbioflor®: Escherichia coli and Enterococcus faecalis) from week 5 until 7 months of life and were followed-up until 3 years of life. Blood samples for eosinophil counts were taken at 4-5 weeks and 7 months of life. Elevation of blood eosinophils was defined as counts above 5% of total leukocytes.


At 4 weeks of life and 7 months of life, respectively, 233/559 and 107/467 infants showed elevated blood eosinophils counts in the total study group. Elevated blood eosinophils observed at 4 weeks were significantly associated with the occurrence of AD in the whole study group at the time points 7 months (p =0.0073), one year (p=0.0035), two years (p=0.0069) and three years (p=0.006) of life. This observation was seen in the active group as well as the placebo treated group. Blood eosinophil counts at 7 months of life showed only borderline significance for developing AD (p=0.06) at the same age, and blood eosinophil counts at one year of life showed no association with AD.


Elevated blood eosinophils at age 4 weeks of life seem to be of predictive value for the onset of atopic dermatitis in infancy and early childhood in a high risk birth cohort. Eosinophil counts later in infancy were less correlated with AD prevalence. Early eosinophil counts can therefore be helpful for counseling the parents but furthermore can identify target groups for interventional trials aiming at allergy prevention.

Authors’ Affiliations

Department for Pediatric Pneumology and Immunology, Charité University Hospital, Berlin, Germany
GE-ME Design and Analyse Klinischer Prüfung, Frankfurt, Germany
SymbioPharm GmbH, Herborn, Germany
TG Medical Services, Berlin, Germany


© Rossberg et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.