Skip to main content

PD46 - Serum level of S 100 proteins in patients with asthma

Aim

Asthma is a chronic disease of the lower respiratory tract that is characterized by inflammation and bronchial obstruction. The pathophysiology of the disease is related to constriction of the bronchial smooth muscle, something that is influenced by calcium homeostasis. Important role in calcium homeostasis, play various binding proteins, which belongs to the family of proteins S100 (S100). The purpose of this study was to measure S100 protein in a group of children with bronchial asthma (BA) in comparison with age-sex matched control group.

Materials and methods

10 patients (mean age 8±4.6, 6♂ and 4♀) and 10 age-sex matched controls (mean age 7.4±3.1, 4♂ and 6♀) were included in our study; Patients with acute infection were excluded from this study in order to avoid blases that could lead to misinterpretation. Serum S100 protein was determined by electrochemeluminescent method and level of protein ≥ 0,105µg/l was considered positive.

Results

All asthmatic patients (100%) had abnormal serum levels of S100. Asthmatic patients presented a significantly higher level of S100 in comparison to control subjects (0.31μg/l vs 0.065μg/l, p<0.05).

Conclusions

Our results in this study group demonstrated that S 100 elevated in asthmatic children, in a statistical significant manner. The role of S100 needs to be further investigated, imposing a possible new therapeutic target in the pathophysiology of asthma.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Dimitrios Cassimos.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Gioka, T., Konstantinidis, T., Tsigalou, C. et al. PD46 - Serum level of S 100 proteins in patients with asthma. Clin Transl Allergy 4, P46 (2014). https://doi.org/10.1186/2045-7022-4-S1-P46

Download citation

Keywords

  • Asthma
  • Serum Level
  • Respiratory Tract
  • S100 Protein
  • Asthmatic Patient