Skip to content

Advertisement

  • Poster discussion presentation
  • Open Access

PD43 - Body fat mass is positively associated with pediatric asthma

  • 1,
  • 2,
  • 1,
  • 2,
  • 1,
  • 2 and
  • 1
Clinical and Translational Allergy20144 (Suppl 1) :P43

https://doi.org/10.1186/2045-7022-4-S1-P43

  • Published:

Keywords

  • Asthma
  • Logistic Regression Model
  • Inflammatory Mediator
  • Anthropometric Measurement
  • Pathophysiologic Mechanism

Background

Prevalence of pediatric overweight/obesity and pediatric asthma has been on the rise, with both conditions currently reaching epidemic proportions. Their concurrent rise alludes to potentially common characteristics of their pathophysiologic mechanisms; furthermore, excess fat mass may facilitate asthma induction via obesity-related inflammatory mediators, oxidant stress and mechanical chest restriction. However, although such a link is well-documented in adults, it is not yet established in children. We thus opted to investigate into a potential adiposity/asthma association in a cross-sectional, population-based study in preschoolers, by using several indices to assess fat mass.

Methods

Wheeze ever/in the last 12 months (current) and physician-diagnosed asthma were recorded from questionnaires filled in by the parents of 2015 children aged 9-13. Perinatal data was collected from their medical records and the questionnaires; anthropometric measurements and bioelectric impedance analysis (BIA) were conducted. Logistic regression models were build in the Statistical Package for Social Sciences (SPSS version 20.0), with the wheeze/asthma variables as main outcomes. A two-tailed p value less that 0.05, was considered statistically significant.

Results

Physician-diagnosed asthma correlated with z scores of BMI (OR=1.17 95%CI=1.05-1.31, p=0.005), waist circumference (OR=1.16 95%CI=1.03-1.32, p=0.017), waist-to-height ratio (OR=1.18 95%CI=1.04-1.34, p=0.009), sum skinfold thickness at 4 sites (biceps, triceps, subscapular, suprailliac) (OR=1.21 95%CI=1.07-1.38, p=0.002) and bioelectric impedance-derived percentage fat mass (OR=1.23 95%CI=1.07-1.40, p=0.003), following adjustment for several potential confounding factors (prenatal smoking, gestational age, birth weight, gender, parity, breastfeeding, passive smoking at home and parental educational level). Parental-reported current/ever wheeze was not associated with fat mass.

Conclusions

Body fat mass is positively linked to pediatric asthma prevalence in preadolescent children.

Authors’ Affiliations

(1)
Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
(2)
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece

Copyright

Advertisement