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PD43 - Body fat mass is positively associated with pediatric asthma


Prevalence of pediatric overweight/obesity and pediatric asthma has been on the rise, with both conditions currently reaching epidemic proportions. Their concurrent rise alludes to potentially common characteristics of their pathophysiologic mechanisms; furthermore, excess fat mass may facilitate asthma induction via obesity-related inflammatory mediators, oxidant stress and mechanical chest restriction. However, although such a link is well-documented in adults, it is not yet established in children. We thus opted to investigate into a potential adiposity/asthma association in a cross-sectional, population-based study in preschoolers, by using several indices to assess fat mass.


Wheeze ever/in the last 12 months (current) and physician-diagnosed asthma were recorded from questionnaires filled in by the parents of 2015 children aged 9-13. Perinatal data was collected from their medical records and the questionnaires; anthropometric measurements and bioelectric impedance analysis (BIA) were conducted. Logistic regression models were build in the Statistical Package for Social Sciences (SPSS version 20.0), with the wheeze/asthma variables as main outcomes. A two-tailed p value less that 0.05, was considered statistically significant.


Physician-diagnosed asthma correlated with z scores of BMI (OR=1.17 95%CI=1.05-1.31, p=0.005), waist circumference (OR=1.16 95%CI=1.03-1.32, p=0.017), waist-to-height ratio (OR=1.18 95%CI=1.04-1.34, p=0.009), sum skinfold thickness at 4 sites (biceps, triceps, subscapular, suprailliac) (OR=1.21 95%CI=1.07-1.38, p=0.002) and bioelectric impedance-derived percentage fat mass (OR=1.23 95%CI=1.07-1.40, p=0.003), following adjustment for several potential confounding factors (prenatal smoking, gestational age, birth weight, gender, parity, breastfeeding, passive smoking at home and parental educational level). Parental-reported current/ever wheeze was not associated with fat mass.


Body fat mass is positively linked to pediatric asthma prevalence in preadolescent children.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Guibas, G.V., Manios, Y., Xepapadaki, P. et al. PD43 - Body fat mass is positively associated with pediatric asthma. Clin Transl Allergy 4 (Suppl 1), P43 (2014).

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