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PD41 - Risk factors for side effects during venom immunotherapy in children with hymenoptera venom allergy


Since the side effects during Venom Immunotherapy (VIT) are associated with several risk factors, we aimed to evaluate the association of serum basal tryptase (sBT) levels and of other parameters with the frequency of local and/or systemic reactions during VIT in children.


Children who underwent conventional VIT due to established honeybee or wasp allergy and completed 1-year VIT were included in the study. Data were collected on sBT levels, age, sex, culprit insect, degree of preceding sting reaction, time between last preceding sting reaction and VIT, venom specific IgE concentration, total IgE levels, accompanying asthma and aeroallergen sensitization.


We enrolled 45 children with a mean ((± standart deviation) age of 10.0 ± 3.4 years. VIT with wasp venom was initiated in 39 patients (87%) and with honeybee venom in 6 patients (13%). Seventeen patients (37.8%) had encountered lokal or systemic side effects during VIT. Side effects were present in 41 out of 1448 injections (2.8%). There was no significant difference at sBT levels of children with (4.3 µg/L [3.7-6.3]) or without (4.2 µg/L [3.1-4.7]) side effects (p=0.303). Multivariate logistic regression analysis revealed presence of asthma (odds ratio; [95% confidence interval] (14.2 [2.0–123.5]; p=0.008) as a significant risk factor for side effects during VIT in children.


Results of our study determined an association between accompanying asthma and side effects during VIT. Patients with asthma may need a particularly high degree of surveillance during VIT procedure.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Yavuz, S.T., Sahiner, U.M., Buyuktiryaki, B. et al. PD41 - Risk factors for side effects during venom immunotherapy in children with hymenoptera venom allergy. Clin Transl Allergy 4 (Suppl 1), P41 (2014).

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