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P93 - The role of allergy evaluation in children with eosinophilic esophagitis

  • Maria Zande1,
  • Aspassia Angelakopoulou2,
  • Konstantinos Pitsios1,
  • Ekaterini Politi3,
  • Kleanthis Kleanthous4,
  • Ioanna Panagiotou5,
  • Eleftheria Roma-Giannikou5 and
  • Ekaterini Syrigou1
Clinical and Translational Allergy20144(Suppl 1):P148

https://doi.org/10.1186/2045-7022-4-S1-P148

Published: 28 February 2014

Keywords

Food AllergyDietary ModificationSkin Prick TestFood AllergenEosinophilic Esophagitis

Aim

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus immune/antigens mediated. It is clinically characterised by symptoms related to esophageal dysfunction and associated with eosinophil-predominant esophageal inflammation. The role of atopy has been clearly demonstrated both in epidemiological and experimental studies and has important implications for diagnosis and therapy.The aim of this study was to assess the relationship between food allergy and eosinophilic esophagitis in the pediatric population, as well as the effect of dietary modifications in patients’ clinical symptoms.

Methods

Thirty-six children aged 7 months to 12 years (median age 80 months), with EoE (esophageal symptoms, biopsy with >15 eosinophils/HPF after the patients have been treated with a PPI for at least 4–8 weeks and other causes have been excluded) were included to group I. Twenty age and sex matched, apparently healthy, infants and children were studied as control group(group II).Serum specific IgEs to cow milk, egg, wheat, rice, corn, soy, chicken, potato, beef, peanut and pork were measured with the CAP-FEIA. Skin prick tests and atopy patch tests (using fresh foods) were performed for the same allergens.

Results

All children in control group had negative CAP, SPT and APT to all food allergens. In group I 30/36 children (83%) had positive APT. Of these, 12/30 (40%) had also positive SPT and 16/30 (53%) had also positive CAP. Of the 30 positive children 4 (4/30, 13%) had positive APT to one food allergen, 3/30 (10%) had positive APT to two food allergens and 23/30 (77%) to 3 or more food allergens. In the APT-positive children, in group I, withdrawing the suspected food allergens for an 8 week period resulted in the improvement of symptoms.

Conclusion

Food allergens seem to be a significant etiologic factor for eosinophilic esophagitis in infants and young children. Skin tests are able to identify, in most of the cases, the responsible food allergens leading to dietary modifications and symptom remission.

Authors’ Affiliations

(1)
General Hospital, Athens, Greece
(2)
The Hospital for Sick Children, G.O.S, London, Greece
(3)
Cytopathology Department, Areteeio University Hospital, Athens, Greece
(4)
University Hospital, Athens, Greece
(5)
Children's Hospital Agia Sofia, 1st Pediatric Clinic University of Athens, Athens, Greece

Copyright

© Zande et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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