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P87 - A national multicenter registration of treatment with omalizumab in Danish asthmatic children
Clinical and Translational Allergy volume 4, Article number: P142 (2014)
Background
In Denmark, Omalizumab is approved for treating children with severe persistent allergic asthma older than 6 years of age. No systematic registration of the efficacy in the Danish child population according to asthma symptoms or the efficacy on co-morbid allergic symptoms exists. A broad panel of outcome measures is necessary to evaluate the efficacy of Omalizumab treatment.
Aim
To provide a standardized systematic registration in order to create a database enrolling children with severe allergic asthma treated with Omalizumab.
Method and study design
A national multicenter registration and follow-up study based on children with clinical persistent severe allergic asthma including both retrospective and prospective registration.
Inclusion criteria
Children, 6-18 years of age, with severe persistent allergic asthma according to GINA treated with Omalizumab.
Outcome registration
A broad panel of outcome measures is scheduled at baseline and during treatment:
Outcome
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Asthma exacerbations
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Hospitalizations
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Medication
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Lung function
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ACT score
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Peak-flow
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FeNO
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Mannitol/Methacholin test
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Skin prick-test
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Quality of life score. (Juniper)
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Rhinitis score, R-RTSS
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SCORAD score
The monitoring plan and follow-up programme will be presented in a flowchart.
Conclusion
We believe that a national systematic registration will increase knowledge regarding efficacy of Omalizumab treatment in this rare group of severe allergic asthmatic children.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Cite this article
Spangenberg, K.B., Jørgensen, I.M., Halken, S. et al. P87 - A national multicenter registration of treatment with omalizumab in Danish asthmatic children. Clin Transl Allergy 4 (Suppl 1), P142 (2014). https://doi.org/10.1186/2045-7022-4-S1-P142
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DOI: https://doi.org/10.1186/2045-7022-4-S1-P142
Keywords
- Asthma
- Rhinitis
- Asthmatic Child
- Allergic Asthma
- Asthma Exacerbation