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P87 - A national multicenter registration of treatment with omalizumab in Danish asthmatic children

Background

In Denmark, Omalizumab is approved for treating children with severe persistent allergic asthma older than 6 years of age. No systematic registration of the efficacy in the Danish child population according to asthma symptoms or the efficacy on co-morbid allergic symptoms exists. A broad panel of outcome measures is necessary to evaluate the efficacy of Omalizumab treatment.

Aim

To provide a standardized systematic registration in order to create a database enrolling children with severe allergic asthma treated with Omalizumab.

Method and study design

A national multicenter registration and follow-up study based on children with clinical persistent severe allergic asthma including both retrospective and prospective registration.

Inclusion criteria

Children, 6-18 years of age, with severe persistent allergic asthma according to GINA treated with Omalizumab.

Outcome registration

A broad panel of outcome measures is scheduled at baseline and during treatment:

Outcome

  • Asthma exacerbations

  • Hospitalizations

  • Medication

  • Lung function

  • ACT score

  • Peak-flow

  • FeNO

  • Mannitol/Methacholin test

  • Skin prick-test

  • Quality of life score. (Juniper)

  • Rhinitis score, R-RTSS

  • SCORAD score

The monitoring plan and follow-up programme will be presented in a flowchart.

Conclusion

We believe that a national systematic registration will increase knowledge regarding efficacy of Omalizumab treatment in this rare group of severe allergic asthmatic children.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Spangenberg, K.B., Jørgensen, I.M., Halken, S. et al. P87 - A national multicenter registration of treatment with omalizumab in Danish asthmatic children. Clin Transl Allergy 4, P142 (2014). https://doi.org/10.1186/2045-7022-4-S1-P142

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  • DOI: https://doi.org/10.1186/2045-7022-4-S1-P142

Keywords

  • Asthma
  • Rhinitis
  • Asthmatic Child
  • Allergic Asthma
  • Asthma Exacerbation